ID   CTHL7_BOVIN             Reviewed;         165 AA.
AC   P56425; A6QPU1; B9TUC8;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Cathelicidin-7;
DE   AltName: Full=Antibacterial peptide BMAP-34;
DE   Flags: Precursor;
GN   Name=CATHL7; Synonyms=BMAP34;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9409740; DOI=10.1016/s0014-5793(97)01310-0;
RA   Scocchi M., Wang S., Zanetti M.;
RT   "Structural organization of the bovine cathelicidin gene family and
RT   identification of a novel member.";
RL   FEBS Lett. 417:311-315(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate 44N, Isolate 80U, and Isolate JEW38;
RX   PubMed=19136450; DOI=10.1093/jhered/esn112;
RA   Gillenwaters E.N., Seabury C.M., Elliott J.S., Womack J.E.;
RT   "Sequence analysis and polymorphism discovery in 4 members of the bovine
RT   cathelicidin gene family.";
RL   J. Hered. 100:241-245(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus, and Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exerts a potent antimicrobial activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in bone marrow myeloid cells, spleen and
CC       testis.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR   EMBL; Y12729; CAA73261.1; -; Genomic_DNA.
DR   EMBL; Y12728; CAA73261.1; JOINED; Genomic_DNA.
DR   EMBL; EU380709; ACC61287.1; -; Genomic_DNA.
DR   EMBL; EU380711; ACC61289.1; -; Genomic_DNA.
DR   EMBL; EU380715; ACC61293.1; -; Genomic_DNA.
DR   EMBL; BC149488; AAI49489.1; -; mRNA.
DR   EMBL; BC149577; AAI49578.1; -; mRNA.
DR   RefSeq; NP_777256.1; NM_174831.2.
DR   AlphaFoldDB; P56425; -.
DR   SMR; P56425; -.
DR   STRING; 9913.ENSBTAP00000003930; -.
DR   PaxDb; P56425; -.
DR   PeptideAtlas; P56425; -.
DR   PRIDE; P56425; -.
DR   Ensembl; ENSBTAT00000003930; ENSBTAP00000003930; ENSBTAG00000003022.
DR   GeneID; 317650; -.
DR   KEGG; bta:317650; -.
DR   CTD; 820; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003022; -.
DR   eggNOG; ENOG502SAES; Eukaryota.
DR   GeneTree; ENSGT00390000000410; -.
DR   HOGENOM; CLU_121724_1_1_1; -.
DR   InParanoid; P56425; -.
DR   OMA; ICCRETS; -.
DR   OrthoDB; 1534863at2759; -.
DR   TreeFam; TF338457; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000003022; Expressed in thymus and 25 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   InterPro; IPR022746; Cathlecidin_C.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; PTHR10206; 1.
DR   Pfam; PF12153; CAP18_C; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Antibiotic; Antimicrobial; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..130
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000004718"
FT   PEPTIDE         131..164
FT                   /note="Cathelicidin-7"
FT                   /id="PRO_0000004719"
FT   MOD_RES         164
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000255"
FT   DISULFID        86..97
FT                   /evidence="ECO:0000250"
FT   DISULFID        108..125
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   165 AA;  18848 MW;  21F14A0A68C6FBF0 CRC64;
     METQRASFSL GRSSLWLLLL GLVVPSASAQ DLSYREAVLR AVDQFNERSS EANLYRLLEL
     DPPPEQDVEH PGARKPVSFT VKETVCPRTT PQPPEQCDFK ENGLVKQCVG TVTRYWIRGD
     FDITCNNIQS AGLFRRLRDS IRRGQQKILE KARRIGERIK DIFRG