CTHR1_MOUSE
ID CTHR1_MOUSE Reviewed; 245 AA.
AC Q9D1D6; Q3UAP6;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Collagen triple helix repeat-containing protein 1;
DE Flags: Precursor;
GN Name=Cthrc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a negative regulator of collagen matrix
CC deposition. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
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DR EMBL; AK003674; BAB22930.1; -; mRNA.
DR EMBL; AK151282; BAE30268.1; -; mRNA.
DR EMBL; AC164883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466541; EDL08785.1; -; Genomic_DNA.
DR CCDS; CCDS27442.1; -.
DR RefSeq; NP_081054.1; NM_026778.2.
DR AlphaFoldDB; Q9D1D6; -.
DR STRING; 10090.ENSMUSP00000070018; -.
DR GlyGen; Q9D1D6; 1 site.
DR PhosphoSitePlus; Q9D1D6; -.
DR MaxQB; Q9D1D6; -.
DR PaxDb; Q9D1D6; -.
DR PRIDE; Q9D1D6; -.
DR ProteomicsDB; 285217; -.
DR Antibodypedia; 26375; 329 antibodies from 36 providers.
DR DNASU; 68588; -.
DR Ensembl; ENSMUST00000067072; ENSMUSP00000070018; ENSMUSG00000054196.
DR GeneID; 68588; -.
DR KEGG; mmu:68588; -.
DR UCSC; uc007voa.1; mouse.
DR CTD; 115908; -.
DR MGI; MGI:1915838; Cthrc1.
DR VEuPathDB; HostDB:ENSMUSG00000054196; -.
DR eggNOG; ENOG502QSJD; Eukaryota.
DR GeneTree; ENSGT00390000018094; -.
DR HOGENOM; CLU_099891_0_0_1; -.
DR InParanoid; Q9D1D6; -.
DR OMA; CADYPKG; -.
DR OrthoDB; 1198971at2759; -.
DR PhylomeDB; Q9D1D6; -.
DR TreeFam; TF328705; -.
DR BioGRID-ORCS; 68588; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q9D1D6; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9D1D6; protein.
DR Bgee; ENSMUSG00000054196; Expressed in endochondral bone and 186 other tissues.
DR ExpressionAtlas; Q9D1D6; baseline and differential.
DR Genevisible; Q9D1D6; MM.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR GO; GO:0016528; C:sarcoplasm; IDA:MGI.
DR GO; GO:0005109; F:frizzled binding; IPI:MGI.
DR GO; GO:0017147; F:Wnt-protein binding; IPI:MGI.
DR GO; GO:0016477; P:cell migration; ISO:MGI.
DR GO; GO:0090103; P:cochlea morphogenesis; IGI:MGI.
DR GO; GO:0090177; P:establishment of planar polarity involved in neural tube closure; IGI:MGI.
DR GO; GO:0060122; P:inner ear receptor cell stereocilium organization; IGI:MGI.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:MGI.
DR GO; GO:0043932; P:ossification involved in bone remodeling; IMP:MGI.
DR GO; GO:0001649; P:osteoblast differentiation; IMP:MGI.
DR GO; GO:0033687; P:osteoblast proliferation; IMP:MGI.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IMP:MGI.
DR GO; GO:0033690; P:positive regulation of osteoblast proliferation; IMP:MGI.
DR GO; GO:0032092; P:positive regulation of protein binding; IDA:MGI.
DR GO; GO:0060071; P:Wnt signaling pathway, planar cell polarity pathway; IMP:MGI.
PE 2: Evidence at transcript level;
KW Collagen; Extracellular matrix; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..245
FT /note="Collagen triple helix repeat-containing protein 1"
FT /id="PRO_0000021039"
FT DOMAIN 59..92
FT /note="Collagen-like"
FT REGION 64..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 41
FT /note="K -> Q (in Ref. 1; BAB22930)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 245 AA; 26460 MW; E4441BF70E4C8436 CRC64;
MHPQGRAAPP QLLLGLFLVL LLLLQLSAPI SASENPKVKQ KALIRQREVV DLYNGMCLQG
PAGVPGRDGS PGANGIPGTP GIPGRDGFKG EKGECLRESF EESWTPNYKQ CSWSSLNYGI
DLGKIAECTF TKMRSNSALR VLFSGSLRLK CRNACCQRWY FTFNGAECSG PLPIEAIIYL
DQGSPELNST INIHRTSSVE GLCEGIGAGL VDVAIWVGTC SDYPKGDAST GWNSVSRIII
EELPK
