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CTIF_HUMAN
ID   CTIF_HUMAN              Reviewed;         598 AA.
AC   O43310; B3KTR8; Q8IVD5;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=CBP80/20-dependent translation initiation factor;
GN   Name=CTIF; Synonyms=KIAA0427;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=9455477; DOI=10.1093/dnares/4.5.307;
RA   Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N.,
RA   Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. VIII. 78
RT   new cDNA clones from brain which code for large proteins in vitro.";
RL   DNA Res. 4:307-313(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA   Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA   Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA   Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA   Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA   Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA   Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA   Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-578 (ISOFORM 1).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Platelet;
RX   PubMed=18088087; DOI=10.1021/pr0704130;
RA   Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA   Schuetz C., Walter U., Gambaryan S., Sickmann A.;
RT   "Phosphoproteome of resting human platelets.";
RL   J. Proteome Res. 7:526-534(2008).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [7]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [8]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH NCBP1,
RP   AND INTERACTION WITH THE EIF-3 COMPLEX.
RX   PubMed=19648179; DOI=10.1101/gad.1823409;
RA   Kim K.M., Cho H., Choi K., Kim J., Kim B.-W., Ko Y.-G., Jang S.K.,
RA   Kim Y.K.;
RT   "A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding
RT   protein CBP80/20-dependent translation.";
RL   Genes Dev. 23:2033-2045(2009).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [10]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [11]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN   [12]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [13]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-289 AND SER-299, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [14]
RP   VARIANTS [LARGE SCALE ANALYSIS] LEU-389 AND ILE-438.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: Specifically required for the pioneer round of mRNA
CC       translation mediated by the cap-binding complex (CBC), that takes place
CC       during or right after mRNA export via the nuclear pore complex (NPC).
CC       Acts via its interaction with the NCBP1/CBP80 component of the CBC
CC       complex and recruits the 40S small subunit of the ribosome via eIF3. In
CC       contrast, it is not involved in steady state translation, that takes
CC       place when the CBC complex is replaced by cytoplasmic cap-binding
CC       protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD),
CC       the pioneer round of mRNA translation mediated by the cap-binding
CC       complex playing a central role in nonsense-mediated mRNA decay (NMD).
CC       {ECO:0000269|PubMed:19648179}.
CC   -!- SUBUNIT: Interacts with NCBP1/CBP80; the interaction is direct.
CC       Associates with the eukaryotic translation initiation factor 3 (eIF-3)
CC       complex. {ECO:0000269|PubMed:19648179}.
CC   -!- INTERACTION:
CC       O43310-2; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-12180013, EBI-1166928;
CC       O43310-2; Q9NUU7: DDX19A; NbExp=4; IntAct=EBI-12180013, EBI-740301;
CC       O43310-2; Q9UMR2: DDX19B; NbExp=3; IntAct=EBI-12180013, EBI-719232;
CC       O43310-2; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-12180013, EBI-5460660;
CC       O43310-2; Q86VS8: HOOK3; NbExp=3; IntAct=EBI-12180013, EBI-1777078;
CC       O43310-2; A9UHW6-2: MIF4GD; NbExp=3; IntAct=EBI-12180013, EBI-9118295;
CC       O43310-2; Q6P9E2: RECK; NbExp=3; IntAct=EBI-12180013, EBI-10253121;
CC       O43310-2; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-12180013, EBI-742688;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000269|PubMed:19648179}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O43310-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O43310-2; Sequence=VSP_013774;
CC   -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:19648179}.
CC   -!- SIMILARITY: Belongs to the CTIF family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA24857.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAG53180.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
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DR   EMBL; AB007887; BAA24857.2; ALT_INIT; mRNA.
DR   EMBL; AC022919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC048380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC042146; AAH42146.1; -; mRNA.
DR   EMBL; AK095970; BAG53180.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS11935.1; -. [O43310-1]
DR   CCDS; CCDS45864.1; -. [O43310-2]
DR   RefSeq; NP_001135869.1; NM_001142397.1. [O43310-2]
DR   RefSeq; NP_055587.1; NM_014772.2. [O43310-1]
DR   RefSeq; XP_006722650.1; XM_006722587.3. [O43310-2]
DR   RefSeq; XP_006722651.1; XM_006722588.3. [O43310-2]
DR   RefSeq; XP_006722652.1; XM_006722589.3.
DR   RefSeq; XP_011524581.1; XM_011526279.2. [O43310-1]
DR   RefSeq; XP_016881591.1; XM_017026102.1. [O43310-2]
DR   AlphaFoldDB; O43310; -.
DR   SMR; O43310; -.
DR   BioGRID; 115150; 68.
DR   CORUM; O43310; -.
DR   IntAct; O43310; 9.
DR   STRING; 9606.ENSP00000372459; -.
DR   TCDB; 1.I.1.1.3; the nuclear pore complex (npc) family.
DR   iPTMnet; O43310; -.
DR   PhosphoSitePlus; O43310; -.
DR   BioMuta; CTIF; -.
DR   EPD; O43310; -.
DR   jPOST; O43310; -.
DR   MassIVE; O43310; -.
DR   MaxQB; O43310; -.
DR   PaxDb; O43310; -.
DR   PeptideAtlas; O43310; -.
DR   PRIDE; O43310; -.
DR   ProteomicsDB; 48885; -. [O43310-1]
DR   ProteomicsDB; 48886; -. [O43310-2]
DR   Antibodypedia; 9256; 56 antibodies from 14 providers.
DR   DNASU; 9811; -.
DR   Ensembl; ENST00000256413.8; ENSP00000256413.3; ENSG00000134030.14. [O43310-1]
DR   Ensembl; ENST00000382998.8; ENSP00000372459.3; ENSG00000134030.14. [O43310-2]
DR   Ensembl; ENST00000634350.1; ENSP00000489354.1; ENSG00000282825.2. [O43310-2]
DR   Ensembl; ENST00000635228.2; ENSP00000489589.1; ENSG00000282825.2. [O43310-1]
DR   GeneID; 9811; -.
DR   KEGG; hsa:9811; -.
DR   MANE-Select; ENST00000256413.8; ENSP00000256413.3; NM_014772.3; NP_055587.1.
DR   UCSC; uc002ldc.4; human. [O43310-1]
DR   CTD; 9811; -.
DR   DisGeNET; 9811; -.
DR   GeneCards; CTIF; -.
DR   HGNC; HGNC:23925; CTIF.
DR   HPA; ENSG00000134030; Low tissue specificity.
DR   MIM; 613178; gene.
DR   neXtProt; NX_O43310; -.
DR   OpenTargets; ENSG00000134030; -.
DR   PharmGKB; PA134974369; -.
DR   VEuPathDB; HostDB:ENSG00000134030; -.
DR   eggNOG; KOG3942; Eukaryota.
DR   GeneTree; ENSGT00940000153432; -.
DR   HOGENOM; CLU_031968_1_0_1; -.
DR   InParanoid; O43310; -.
DR   OMA; DFSMREE; -.
DR   OrthoDB; 578545at2759; -.
DR   PhylomeDB; O43310; -.
DR   TreeFam; TF350740; -.
DR   PathwayCommons; O43310; -.
DR   SignaLink; O43310; -.
DR   BioGRID-ORCS; 9811; 13 hits in 1079 CRISPR screens.
DR   ChiTaRS; CTIF; human.
DR   GenomeRNAi; 9811; -.
DR   Pharos; O43310; Tbio.
DR   PRO; PR:O43310; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; O43310; protein.
DR   Bgee; ENSG00000134030; Expressed in primary visual cortex and 98 other tissues.
DR   ExpressionAtlas; O43310; baseline and differential.
DR   Genevisible; O43310; HS.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008494; F:translation activator activity; IBA:GO_Central.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IMP:UniProtKB.
DR   GO; GO:0006446; P:regulation of translational initiation; IMP:UniProtKB.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   Pfam; PF02854; MIF4G; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Alternative splicing; Cytoplasm; Nonsense-mediated mRNA decay;
KW   Phosphoprotein; Reference proteome; Translation regulation.
FT   CHAIN           1..598
FT                   /note="CBP80/20-dependent translation initiation factor"
FT                   /id="PRO_0000050754"
FT   DOMAIN          376..577
FT                   /note="MIF4G"
FT   REGION          1..305
FT                   /note="Interaction with NCBP1/CBP80"
FT                   /evidence="ECO:0000269|PubMed:19648179"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          43..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          180..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..279
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..334
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0007744|PubMed:19413330,
FT                   ECO:0007744|PubMed:22814378"
FT   MOD_RES         18
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         289
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:24275569"
FT   MOD_RES         299
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:18088087,
FT                   ECO:0007744|PubMed:24275569"
FT   VAR_SEQ         357
FT                   /note="K -> KVP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_013774"
FT   VARIANT         82
FT                   /note="P -> L (in dbSNP:rs2277712)"
FT                   /id="VAR_020041"
FT   VARIANT         389
FT                   /note="V -> L (in a breast cancer sample; somatic mutation;
FT                   dbSNP:rs751006365)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_035749"
FT   VARIANT         438
FT                   /note="M -> I (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_035750"
SQ   SEQUENCE   598 AA;  67587 MW;  9F8776857A7DDC8A CRC64;
     MENSSAASAS SEAGSSRSQE IEELERFIDS YVLEYQVQGL LADKTEGDGE SERTQSHISQ
     WTADCSEPLD SSCSFSRGRA PPQQNGSKDN SLDMLGTDIW AANTFDSFSG ATWDLQPEKL
     DFTQFHRKVR HTPKQPLPHI DREGCGKGKL EDGDGINLND IEKVLPAWQG YHPMPHEVEI
     AHTKKLFRRR RNDRRRQQRP PGGNKPQQHG DHQPGSAKHN RDHQKSYQGG SAPHPSGRPT
     HHGYSQNRRW HHGNMKHPPG DKGEAGAHRN AKETMTIENP KLEDTAGDTG HSSLEAPRSP
     DTLAPVASER LPPQQSGGPE VETKRKDSIL PERIGERPKI TLLQSSKDRL RRRLKEKDEV
     AVETTTPQQN KMDKLIEILN SMRNNSSDVD TKLTTFMEEA QNSTNSEEML GEIVRTIYQK
     AVSDRSFAFT AAKLCDKMAL FMVEGTKFRS LLLNMLQKDF TVREELQQQD VERWLGFITF
     LCEVFGTMRS STGEPFRVLV CPIYTCLREL LQSQDVKEDA VLCCSMELQS TGRLLEEQLP
     EMMTELLASA RDKMLCPSES MLTRSLLLEV IELHANSWNP LTPPITQYYN RTIQKLTA
 
 
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