ID   CTIF_XENTR              Reviewed;         583 AA.
AC   Q0V9S3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=CBP80/20-dependent translation initiation factor;
GN   Name=ctif;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically required for the pioneer round of mRNA
CC       translation mediated by the cap-binding complex (CBC), that takes place
CC       during or right after mRNA export via the nuclear pore complex (NPC).
CC       In contrast, it is not involved in steady state translation, that takes
CC       place when the CBC complex is replaced by cytoplasmic cap-binding
CC       protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD),
CC       the pioneer round of mRNA translation mediated by the cap-binding
CC       complex playing a central role in nonsense-mediated mRNA decay (NMD)
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CTIF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC121414; AAI21415.1; -; mRNA.
DR   RefSeq; NP_001072334.1; NM_001078866.1.
DR   RefSeq; XP_012820628.1; XM_012965174.2.
DR   AlphaFoldDB; Q0V9S3; -.
DR   SMR; Q0V9S3; -.
DR   DNASU; 779787; -.
DR   Ensembl; ENSXETT00000056321; ENSXETP00000056321; ENSXETG00000026836.
DR   GeneID; 779787; -.
DR   KEGG; xtr:779787; -.
DR   CTD; 9811; -.
DR   Xenbase; XB-GENE-5882041; ctif.
DR   InParanoid; Q0V9S3; -.
DR   OrthoDB; 578545at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026836; Expressed in skeletal muscle tissue and 12 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008494; F:translation activator activity; IBA:GO_Central.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   Pfam; PF02854; MIF4G; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nonsense-mediated mRNA decay; Reference proteome;
KW   Translation regulation.
FT   CHAIN           1..583
FT                   /note="CBP80/20-dependent translation initiation factor"
FT                   /id="PRO_0000385189"
FT   DOMAIN          361..562
FT                   /note="MIF4G"
FT   REGION          42..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..154
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..218
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   583 AA;  66640 MW;  7A46977A887B7001 CRC64;
     MESSSVASAS SEAGSSRSLE IEELERFIDS YVLEYQVQGL LTDKTEGDGE SDKTQSNVSQ
     WTVECTERLE ENRTSPRNRE PTYSQNGNKE GPLDMLGTDI WAASTVESIS GATWDLQPEK
     LDFTQLQLRQ RNSPKHPPPQ IDRDGFGKGK RVEGDDINLN DIEKVLPTWQ GYSPLPHEAD
     IAQTKKLFRR KRNDRRKQQK PQGGNKQPPS QQNDHQPATA KHNSREHQRQ YHGNPPPPHP
     SGKQGHHGYS QNRRWHHNQK HLPNDLQRNA KETDTLKIED ASVCTVHIPL DIHSNTDSTE
     RHCPPANDSE AKRKESIQSR DRPKISLLQS SKDRLRRRLK EKEDVAVEST NPQKTKMDKL
     IEILNSMRNN SSDVDYKLTT FMAEAQNSAN SEEMLGEIVK TIYQKAVTDR SFAHTAAKLC
     DRMALFMVEG TKFRSLLLNM LQKDFSIREE MHRSDVERWL GFITFLCEVF GTMRSNMAEP
     FRVLVCPIYT CLRELLQSED VKEDAVLCCS MELQSAGRLL EDQLPEMMSE LLATARDKML
     CPSESMLTRS LLLEVIELHA NSWNPLTPTI TQYYNKTIQK LTG