CTK3_SCHPO
ID CTK3_SCHPO Reviewed; 218 AA.
AC Q9USJ8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=CTD kinase subunit gamma;
DE Short=CTDK-I gamma subunit;
DE AltName: Full=CTD kinase subunit 3;
GN Name=ctk3 {ECO:0000250|UniProtKB:P46963}; ORFNames=SPCC4B3.08;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAB60682.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Subunit of the CTDK-I complex, which hyperphosphorylates the
CC C-terminal heptapeptide repeat domain (CTD) of the largest RNA
CC polymerase II subunit. As part of the CTDK-I complex, involved in RNA
CC polymerase II transcriptional elongation and pre-mRNA 3'-end
CC processing. Together with ctk2, required for ctk1/lsk1 CTD kinase
CC activation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: CTDK-I consists of three subunits, ctk1/lsk1, ctk2/lsc1 and
CC ctk3 (also called alpha, beta and gamma). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the CTK3 family. {ECO:0000305}.
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DR EMBL; CU329672; CAB60682.1; -; Genomic_DNA.
DR PIR; T50440; T50440.
DR RefSeq; NP_588082.1; NM_001023074.2.
DR PDB; 5CE7; X-ray; 2.00 A; A=1-140.
DR PDBsum; 5CE7; -.
DR AlphaFoldDB; Q9USJ8; -.
DR SMR; Q9USJ8; -.
DR BioGRID; 276116; 68.
DR STRING; 4896.SPCC4B3.08.1; -.
DR MaxQB; Q9USJ8; -.
DR PaxDb; Q9USJ8; -.
DR PRIDE; Q9USJ8; -.
DR EnsemblFungi; SPCC4B3.08.1; SPCC4B3.08.1:pep; SPCC4B3.08.
DR GeneID; 2539555; -.
DR KEGG; spo:SPCC4B3.08; -.
DR PomBase; SPCC4B3.08; -.
DR VEuPathDB; FungiDB:SPCC4B3.08; -.
DR eggNOG; ENOG502S1MK; Eukaryota.
DR HOGENOM; CLU_051552_0_0_1; -.
DR InParanoid; Q9USJ8; -.
DR OMA; RENIWAI; -.
DR PhylomeDB; Q9USJ8; -.
DR BRENDA; 2.7.11.23; 5613.
DR PRO; PR:Q9USJ8; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0070692; C:CTDK-1 complex; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005509; F:calcium ion binding; NAS:PomBase.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IBA:GO_Central.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:PomBase.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IC:PomBase.
DR GO; GO:0023052; P:signaling; NAS:PomBase.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR006569; CID_dom.
DR InterPro; IPR042326; Ctk3.
DR InterPro; IPR024637; Ctk3_C.
DR InterPro; IPR024638; Ctk3_N.
DR InterPro; IPR008942; ENTH_VHS.
DR PANTHER; PTHR28291; PTHR28291; 1.
DR Pfam; PF12243; CTK3; 1.
DR Pfam; PF12350; CTK3_C; 1.
DR PROSITE; PS51391; CID; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; mRNA processing; Nucleus; Reference proteome;
KW Transcription.
FT CHAIN 1..218
FT /note="CTD kinase subunit gamma"
FT /id="PRO_0000338604"
FT DOMAIN 2..138
FT /note="CID"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00724"
FT REGION 137..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 3..14
FT /evidence="ECO:0007829|PDB:5CE7"
FT HELIX 21..23
FT /evidence="ECO:0007829|PDB:5CE7"
FT HELIX 25..33
FT /evidence="ECO:0007829|PDB:5CE7"
FT HELIX 35..37
FT /evidence="ECO:0007829|PDB:5CE7"
FT HELIX 38..51
FT /evidence="ECO:0007829|PDB:5CE7"
FT HELIX 54..73
FT /evidence="ECO:0007829|PDB:5CE7"
FT HELIX 80..86
FT /evidence="ECO:0007829|PDB:5CE7"
FT HELIX 88..95
FT /evidence="ECO:0007829|PDB:5CE7"
FT HELIX 100..118
FT /evidence="ECO:0007829|PDB:5CE7"
FT HELIX 124..139
FT /evidence="ECO:0007829|PDB:5CE7"
SQ SEQUENCE 218 AA; 24640 MW; 4AA0F1E5B24B842D CRC64;
MDPFEGRMTF LQLLGKLNAS QFSQIKPAQF AIKHLDLEED LYSCIWEELE SGSFNTRVNI
MYFVDTLCEM CLKNGLTGGY LNMISRDICK LVQNVAPIGA AGAANAPEVR KVLQSLHEKK
VIDDNQYKDA MATVEAHEQA SKSGDTSTSG AISKNDILKR IEEDRERHKR MRENIWAISE
PELEAEIAWN TTQGITESDL ESLKDEYEKF NECLHATS
