CTL12_ANOGA
ID CTL12_ANOGA Reviewed; 790 AA.
AC Q7PRJ0;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 4.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Choline transporter-like 2 {ECO:0000250|UniProtKB:Q9VAP3};
GN Name=Ctl2 {ECO:0000250|UniProtKB:Q9VAP3}; ORFNames=AGAP010343;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAAB01008849; EAA07143.5; -; Genomic_DNA.
DR RefSeq; XP_311599.4; XM_311599.4.
DR AlphaFoldDB; Q7PRJ0; -.
DR SMR; Q7PRJ0; -.
DR STRING; 7165.AGAP010343-PC; -.
DR GeneID; 1272697; -.
DR KEGG; aga:AgaP_AGAP010343; -.
DR CTD; 1272697; -.
DR VEuPathDB; VectorBase:AGAP010343; -.
DR eggNOG; KOG1362; Eukaryota.
DR HOGENOM; CLU_017181_3_1_1; -.
DR InParanoid; Q7PRJ0; -.
DR OrthoDB; 329225at2759; -.
DR PhylomeDB; Q7PRJ0; -.
DR Proteomes; UP000007062; Chromosome 3L.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..790
FT /note="Choline transporter-like 2"
FT /id="PRO_0000359733"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 545..565
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 592..612
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 691..711
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 728..748
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 259
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 384
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 483
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 790 AA; 89735 MW; 19346412ABB14695 CRC64;
MGLCCGSTDR VTKYSKEDIQ QPTESEPLKY DPDFKGPLSK RSCTDLPCLF LFVTFLCAWG
YVAYYAVQHG DLNRLLVPID SDGRKCGVDS EVRDEPYLVF FNITECAKID VPISGCSTTQ
VCVSQCPNQD FDFESANCNP SNVNEIRSKL ICKQNVKKSD LTTCQIIRQY IKSQRCAQTM
QKSTPLVNRC VSNIPEGQCT LIPKQFRQQP PITSTKFQTS AEQCKEQREL ENILEEKISK
LQSFLARYVN NLISVLTKNN SVHQLKYLNY HLVLQTLKKG NLKHNPLIIT PYLITIHNIT
VLLTFQMIVE DILESWRMIL VFIACSVLAS LILIAMLRWI AKPLVWISII GVITALSYGV
YYSFRQYQQI RANPVAAHVN VSPNLSSLVN SWFKSDQTWL WILIALSVIL IVLLLVVLVL
RKRIVIAIAL LKEGSKAVSA SFSTVFFPLV PWILQAVVIV FSLLVLLFLA SIGVPVYKVN
GLNSSLTCVC TNGYMEGDIC DPVAFNENCR DTSRIYDQER CLDAACHFQE VDTPGIVRFF
HALNVIGFFW CICFVSAFSE MVLAFTFATW YWTRQKSRLP FFVLTRGVTH TVYYHLGTLA
FGSLIIAICK IIRAILEYVD HKLKRYDNGF TRAVLCCCRC FFWCLESFLK FLNRNAYIMC
AIYGKNFCSS AKDAFSLLTR NVLRVIALDK VTGFLFFLSK LLLASGMAAV TYTYFDSDLP
KMQLNYPFVP AVLVFIGTFI IASIFFSVYS VAVDTLFLCF LEDIERNDGS AERPFYMSRG
LQKILGKKQK
