CTL12_DROME
ID CTL12_DROME Reviewed; 796 AA.
AC Q9VAP3;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Choline transporter-like 2 {ECO:0000312|FlyBase:FBgn0039637};
GN Name=Ctl2 {ECO:0000312|FlyBase:FBgn0039637};
GN ORFNames=CG11880 {ECO:0000312|FlyBase:FBgn0039637};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014297; AAF56859.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN14152.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN14153.1; -; Genomic_DNA.
DR RefSeq; NP_651670.1; NM_143413.2.
DR RefSeq; NP_733268.1; NM_170389.2.
DR RefSeq; NP_733269.1; NM_170390.2.
DR AlphaFoldDB; Q9VAP3; -.
DR SMR; Q9VAP3; -.
DR BioGRID; 68311; 4.
DR STRING; 7227.FBpp0084740; -.
DR GlyGen; Q9VAP3; 5 sites.
DR PaxDb; Q9VAP3; -.
DR PRIDE; Q9VAP3; -.
DR DNASU; 43440; -.
DR EnsemblMetazoa; FBtr0085371; FBpp0084740; FBgn0039637.
DR EnsemblMetazoa; FBtr0085372; FBpp0084741; FBgn0039637.
DR EnsemblMetazoa; FBtr0085373; FBpp0084742; FBgn0039637.
DR GeneID; 43440; -.
DR KEGG; dme:Dmel_CG11880; -.
DR UCSC; CG11880-RA; d. melanogaster.
DR CTD; 110281; -.
DR FlyBase; FBgn0039637; Ctl2.
DR VEuPathDB; VectorBase:FBgn0039637; -.
DR eggNOG; KOG1362; Eukaryota.
DR GeneTree; ENSGT00940000172011; -.
DR HOGENOM; CLU_017181_3_1_1; -.
DR InParanoid; Q9VAP3; -.
DR OMA; CIAYWAC; -.
DR OrthoDB; 329225at2759; -.
DR PhylomeDB; Q9VAP3; -.
DR Reactome; R-DME-1483191; Synthesis of PC.
DR Reactome; R-DME-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 43440; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 43440; -.
DR PRO; PR:Q9VAP3; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039637; Expressed in saliva-secreting gland and 24 other tissues.
DR ExpressionAtlas; Q9VAP3; baseline and differential.
DR Genevisible; Q9VAP3; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..796
FT /note="Choline transporter-like 2"
FT /id="PRO_0000359734"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 585..605
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 626..648
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 691..711
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 724..744
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 209
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 284
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 488
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 520
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 796 AA; 90629 MW; 20961DD889A3EE3B CRC64;
MTESVELMNK YGEPLRYDRN FTGPRQRDRS CTDVPCLLLF VLFLGGWAFI AQYAIRNGDL
NKLLVPTDSF NRKCGMDSGV LNKKNLFFFD LNQCIDPLVP ITGCDTPQVC VETCPRETFV
WDTMKDKQSF AELHSRLICL SEEHKAQIRT KSDIQDAINQ NQCARWYIKS APFLKRCLFE
FSQGVCDYIP SFLLNGGRSR RELHMLPGNA TTEVQMQADV MYQKMTDAQA LVVPQANGKQ
TPVDEEPIIQ CKRRLNEAVI KEKMMQTDTR LAKLVGNMVA HFYNGTNDAQ LLGEKIVEDL
VNSWSIVLVA CFCTLVASLI YIALMRWLSA PILWFSIFGV LIGLLVGIYF SVKQYIHWEN
TPTVPVHGLN LHSTVKNVLQ NQNTWLYLSI FVGVCFVVIL LLVIVLRKRI RIAIALTKEG
SKAVSSVIST VFFPIFSWIL FIAAIAFAIG VGLYLGSIGD PSFRMVRQLT KSGEVTTEDC
VCEGPAINYT VGGSCKPEVF QQYCSVRLTS FFQNRNPCLN TTCSFDSINN PIEIKWAIFY
NVFGFLWLSF FISAFSYMVL ASTFARWYWT FKKRDVPYFT LTRAFFQTAV YHLGTVAFGS
LILAIVRLIR LVLEYIHEKL KKYDNAVTRA ILCCMRCFFW LLETFLKFLN RNAYIMCAIH
GKNFCSSAAD SFNLIMRNFL RVVTLDQVTD FLFFLSKLLL TAGAGASTYY FLDNNPSIIR
LNYIAVPTTV VVIAAFLITS VFFGVYSTAV DTLFLCFLED CERNDGSPEK PFFMSKQLMK
ILGKKNNLPP RQRRGK
