ID   CTL1L_AEDAE             Reviewed;         689 AA.
AC   Q17JQ7;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Choline transporter-like 1 {ECO:0000250|UniProtKB:Q9VZE7};
GN   Name=Ctl1 {ECO:0000250|UniProtKB:Q9VZE7}; ORFNames=AAEL001935;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC       {ECO:0000305}.
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DR   EMBL; CH477231; EAT46917.1; -; Genomic_DNA.
DR   RefSeq; XP_001654328.1; XM_001654278.1.
DR   AlphaFoldDB; Q17JQ7; -.
DR   SMR; Q17JQ7; -.
DR   GeneID; 5573001; -.
DR   KEGG; aag:5573001; -.
DR   VEuPathDB; VectorBase:AAEL001935; -.
DR   eggNOG; KOG1362; Eukaryota.
DR   HOGENOM; CLU_017181_2_0_1; -.
DR   InParanoid; Q17JQ7; -.
DR   OMA; YCLEKFI; -.
DR   OrthoDB; 329225at2759; -.
DR   PhylomeDB; Q17JQ7; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR007603; Choline_transptr-like.
DR   PANTHER; PTHR12385; PTHR12385; 1.
DR   Pfam; PF04515; Choline_transpo; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..689
FT                   /note="Choline transporter-like 1"
FT                   /id="PRO_0000359729"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        562..582
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        591..611
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        279
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        375
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        389
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   689 AA;  77605 MW;  334A9117597EC6AA CRC64;
     MGCFESKPSE QHQPTAVRGC TDIFWLVVYI LFWIALLVIA VFSFVYGNPL RVINGYDSFG
     NTCGVSSNEK FSHFPLSGMN TKDKPYVFFL DIKELRQTLK ICVKECPKKE IGNAMELYRY
     YEERDTKYCR YDFNMSLLTA PDASGPKYFA FAGPCPKFPV YESSSVLHRC IPSGKNAPTK
     VVKDMYALVN SFGAAQQVFS DIYKTWPTVL LLVGLSLIFS IILIMMLHWL TAIISWLICI
     FVAVASIGIT AVLWWSYYKQ KHSIDTDTKL SYLEELVRNE TTIYVLAILA TCIMIILLVV
     IYYLREKLSG LAALFEEAGK CMLQIPGLAG PPVLAFIALA VFLSFWMVVI VCLATANYPN
     VKPLLPFTQL KENPNKTEAA IKPDMSVNNN TYKSFDLVEY PEADFLRHML WIYIIGLVWT
     SEFIFACQQL VISGAVAYWY FRKPTDTPVL NAIAKLVKYH LGSVAKGSFI ITLFKIPRLI
     LTYLYAKLKR HQQEGSECAS CCLKCCICSF WLLEKFIRYL NHNAYTVIAI ESVNFCPAAK
     IAWNALVTNA LQVATINGIG DLVLFLGKLA VAALCGLISI LMLRDNPDVH FYMAPVIIIT
     LFSFFVAHIV LSLYEMVVDT LFLCVCEDRT INGNSGRWKQ SNLAHLLGES PEQDAVEAPM
     QVVELTPITK QPFSVQSLQM TEIDDKGAV