ID   CTL1L_ANOGA             Reviewed;         690 AA.
AC   Q7Q5R7;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 4.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Choline transporter-like 1 {ECO:0000250|UniProtKB:Q9VZE7};
GN   Name=Ctl1 {ECO:0000250|UniProtKB:Q9VZE7}; ORFNames=AGAP006244;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC       {ECO:0000305}.
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DR   EMBL; AAAB01008960; EAA10766.4; -; Genomic_DNA.
DR   RefSeq; XP_316311.4; XM_316311.4.
DR   AlphaFoldDB; Q7Q5R7; -.
DR   SMR; Q7Q5R7; -.
DR   PaxDb; Q7Q5R7; -.
DR   GeneID; 1276904; -.
DR   KEGG; aga:AgaP_AGAP006244; -.
DR   CTD; 1276904; -.
DR   VEuPathDB; VectorBase:AGAP006244; -.
DR   eggNOG; KOG1362; Eukaryota.
DR   HOGENOM; CLU_017181_2_0_1; -.
DR   InParanoid; Q7Q5R7; -.
DR   OMA; YCLEKFI; -.
DR   OrthoDB; 329225at2759; -.
DR   PhylomeDB; Q7Q5R7; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR007603; Choline_transptr-like.
DR   PANTHER; PTHR12385; PTHR12385; 1.
DR   Pfam; PF04515; Choline_transpo; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..690
FT                   /note="Choline transporter-like 1"
FT                   /id="PRO_0000359730"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        464..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        565..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        594..614
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        391
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   690 AA;  77707 MW;  8949A49E9E2D4D15 CRC64;
     MGCFESKPDQ QVQPVTVRSP TDIFWLVLYV VFWIALIVIA VFSFIYGNPL RIINGYDSFG
     NTCGVRSNDK FSNFPLSGMN TEDKPYLFFL DIKELRHTLK ICVKECPQRE LLNAAELYRY
     YEDRKTKLCR YDFNMSMLQT QEANQGAKYF DFNGPCPPFP VYQSAPVLHR CIPTGVNAPL
     QQVKKMYALI NSWEATQQVF SDLYKAWPTI VLICALSLVF SIVMIALLHW LATIVSWLIC
     IIVVVASVGI TGVLWWSYYK AKHTLDTDQQ LSYLEELVRN EATIYVLAIA ATCIMIILLV
     VIYYLREKLT GLAALFEEAG KCMLQLPGLA GPPLLAFLAL SVFLAFWVVV VVCLATANYP
     GVKPLLPLAQ LEDSASIAND PKLKPELAGK NDTSFKSFKL VEYHDVNVLR HMLWIYIIGL
     IWTSEFIFAC QQLAIAGAVA FWYFRKPTDS PVLLAIAKLV KYHLGSVAKG SLIITIFKIP
     RLILTYLYAK LKRHQQEGSE CASCCLRCCI CSFWLLEKFI RYLNHNAYTV IAIEGVNFCP
     AAKIAWNALV TNALQVATIN GIGDFVLFLG KLAVASICGL ISILLLRDNP DLHFYMAPVI
     IITVFAFFIA HIILSLYEMV VDTLFLCVCE DRTINGNSGR WKESNLARLL GEAPEEDAVE
     APMQEVQLTP ITKQPFSAQF LQAEMENSKA