CTL1L_CAEEL
ID CTL1L_CAEEL Reviewed; 771 AA.
AC Q20026; B3WFU3; Q8MQ62;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Choline transporter-like protein 1;
GN Name=chtl-1; ORFNames=F35C8.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=Q20026-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q20026-2; Sequence=VSP_036154;
CC Name=c;
CC IsoId=Q20026-3; Sequence=VSP_036155;
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
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DR EMBL; FO080312; CCD62786.1; -; Genomic_DNA.
DR EMBL; FO080312; CCD62787.1; -; Genomic_DNA.
DR EMBL; FO080312; CCD62790.1; -; Genomic_DNA.
DR PIR; T16254; T16254.
DR RefSeq; NP_001129928.1; NM_001136456.2.
DR RefSeq; NP_741789.2; NM_171685.5.
DR RefSeq; NP_741790.2; NM_171686.5. [Q20026-2]
DR AlphaFoldDB; Q20026; -.
DR BioGRID; 45742; 1.
DR STRING; 6239.F35C8.7c.1; -.
DR EPD; Q20026; -.
DR PaxDb; Q20026; -.
DR PeptideAtlas; Q20026; -.
DR PRIDE; Q20026; -.
DR EnsemblMetazoa; F35C8.7a.1; F35C8.7a.1; WBGene00018037. [Q20026-1]
DR EnsemblMetazoa; F35C8.7b.1; F35C8.7b.1; WBGene00018037. [Q20026-2]
DR EnsemblMetazoa; F35C8.7c.1; F35C8.7c.1; WBGene00018037. [Q20026-3]
DR GeneID; 180809; -.
DR KEGG; cel:CELE_F35C8.7; -.
DR UCSC; F35C8.7b; c. elegans.
DR CTD; 180809; -.
DR WormBase; F35C8.7a; CE04499; WBGene00018037; chtl-1. [Q20026-1]
DR WormBase; F35C8.7b; CE30970; WBGene00018037; chtl-1. [Q20026-2]
DR WormBase; F35C8.7c; CE42729; WBGene00018037; chtl-1. [Q20026-3]
DR eggNOG; KOG1362; Eukaryota.
DR GeneTree; ENSGT00940000172011; -.
DR HOGENOM; CLU_017181_3_1_1; -.
DR InParanoid; Q20026; -.
DR OMA; ERCAYAN; -.
DR OrthoDB; 329225at2759; -.
DR PhylomeDB; Q20026; -.
DR Reactome; R-CEL-1483191; Synthesis of PC.
DR Reactome; R-CEL-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR PRO; PR:Q20026; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00018037; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..771
FT /note="Choline transporter-like protein 1"
FT /id="PRO_0000359727"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..534
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 566..586
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 603..623
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 662..682
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 701..721
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 259
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 480
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..86
FT /note="MGRKKHRTIPAVEVYEKSDGFPMPTAPPMSPSRMDGVYPSHHVPPLHQAYHV
FT QPASANHVPDQIARFNVIKPDRLAKRHNPQLYTK -> MKQYNYSYEAAPQFCRNSAMA
FT IQTAPGTAESKRDNNPMSDFNLQR (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_036154"
FT VAR_SEQ 238
FT /note="V -> VPV (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_036155"
SQ SEQUENCE 771 AA; 87311 MW; C717488C6EFEBB20 CRC64;
MGRKKHRTIP AVEVYEKSDG FPMPTAPPMS PSRMDGVYPS HHVPPLHQAY HVQPASANHV
PDQIARFNVI KPDRLAKRHN PQLYTKRGCT DVFCCFLFFV FLCGWVVVAG FGIMWGDPQR
LIYPTDSEFR RCGVNLEGSY NFSKRPYLFY FDLTKCISYA TALGGCQTTQ LCVKECPSTY
FSYLQLRTAS VSEIQNKMKS VVYCTDDVDK TTVTTFQALQ NLVQRGKCVS YTVKSVPVLQ
RCFPEAIFNA VDNVNNVLNS SNSLDYLKRT FGDDALIPQD IQITGQSSEV MKSVVEDQPV
THKVIHDLSQ TWWQTLILIF AAGILSFIWT VIMRLLGSLI IWLSILIVLV ALGFGAGFSW
LKWNTLKTTG AIDDYSFHPA FDAYFEMPTT WLVVAIATSV LLLIFLLVIL FIRQRISIAC
ALISESSKAI GSMMSTLLFP LFPFLLHIGV FALWGSIAIW LASSGQEVCR LKETNGQVYN
TSTKCDCTAK VTGCTYVGIE KESETIFWLQ VYNLFAFFWL SCFVTALGDI ALAGAFASYY
WARDKRHDVP TFPVIRALNR AIRYNLGSIA FGSLIIAIVK IIRVLLEYID HKLGKSQNKA
VKWFLMCLKC CFWCLEVFFK FLTKNAYIMI AIYGKNFFSS AKDSFLLITR NIVRTVVVHK
VAGILLFLGK SMITLGMGIL SFYYFSGRWV VEGVPKVDLY YYFVPIVIVV IGSYFMADLF
FDVYEMAVDT TFICFLEDSE QNDGSLERPF FMSEKLLEIL GNKNDIPLHS K
