CTL1L_DROME
ID CTL1L_DROME Reviewed; 691 AA.
AC Q9VZE7; Q86P33;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Choline transporter-like 1 {ECO:0000312|FlyBase:FBgn0035523};
GN Name=Ctl1 {ECO:0000312|FlyBase:FBgn0035523};
GN ORFNames=CG1311 {ECO:0000312|FlyBase:FBgn0035523};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
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DR EMBL; AE014296; AAF47876.1; -; Genomic_DNA.
DR EMBL; BT003504; AAO39508.1; -; mRNA.
DR RefSeq; NP_647884.1; NM_139627.2.
DR AlphaFoldDB; Q9VZE7; -.
DR STRING; 7227.FBpp0073088; -.
DR GlyGen; Q9VZE7; 2 sites.
DR SwissPalm; Q9VZE7; -.
DR PaxDb; Q9VZE7; -.
DR PRIDE; Q9VZE7; -.
DR EnsemblMetazoa; FBtr0073232; FBpp0073088; FBgn0035523.
DR GeneID; 38523; -.
DR KEGG; dme:Dmel_CG1311; -.
DR UCSC; CG1311-RA; d. melanogaster.
DR CTD; 110280; -.
DR FlyBase; FBgn0035523; Ctl1.
DR VEuPathDB; VectorBase:FBgn0035523; -.
DR eggNOG; KOG1362; Eukaryota.
DR HOGENOM; CLU_017181_2_0_1; -.
DR InParanoid; Q9VZE7; -.
DR OrthoDB; 329225at2759; -.
DR PhylomeDB; Q9VZE7; -.
DR Reactome; R-DME-1483191; Synthesis of PC.
DR Reactome; R-DME-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR Reactome; R-DME-6798163; Choline catabolism.
DR BioGRID-ORCS; 38523; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG1311; fly.
DR GenomeRNAi; 38523; -.
DR PRO; PR:Q9VZE7; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035523; Expressed in eye disc (Drosophila) and 24 other tissues.
DR ExpressionAtlas; Q9VZE7; baseline and differential.
DR Genevisible; Q9VZE7; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..691
FT /note="Choline transporter-like 1"
FT /id="PRO_0000359732"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 562..582
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 591..611
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 385
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 18
FT /note="P -> H (in Ref. 3; AAO39508)"
FT /evidence="ECO:0000305"
FT CONFLICT 661
FT /note="E -> G (in Ref. 3; AAO39508)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 691 AA; 76840 MW; 73309ED51C733208 CRC64;
MGCAESKDGE GEAQNNRPKY RSCTDTCWLA IYIIFWLFLI VIAIFSFVYG NPLRIINGYD
SFGNTCGVKY NEKFQGFPLS GMNTLDKPEL FYFDVKELKK SLKICVKSCP AKTMTKGSEL
LEYYSQTGTQ LCKYDYNMQQ LTTAGNDAKT FNFLGPCPSF PVHESSPVLH RCVPKGTGEK
VQNYYDMLNN WDVAQQFVGD IYSTWHIIAM VCGLALLISI ALVTMMHWLS RIVSWIICVL
VIVASVALTV ALWYAYYNIR NKSGVNTQYS MLEEFVRNQQ AVLTLAVLAT ITMIILIVVI
YFLKNKLAGL SALFEEAGQC MMNLPGLLIA PLLAFLVLIA FLSFWVAVII CLATASSPGQ
SPIAPFDNSK AHQQPLPANA LFVSNSTDVN DLRPNARVEY ADAGVLRSMF WIYVVGLIWT
VEFIFACQQF ALAAAVAFWY FQKPTSTPTF YAIGKLVKYH LGTVAKGSFV ITIFKIPRLI
LTYLYAKLKK GEDKGSECAA CCLKCCICGF WLLEKFIRFL NHNAYTVVAI ESINFCPAAG
IAWNAMATNV LQVATINSVG DFILFLGKVV VAALSGLIGI VLLKDKPGLN FYMAPVIIII
IFSFFIAHII LSLFEMVVDT LFLCVCEDKT LNGRSGRWAQ SNLAKLVGEE PLQPGEEPPI
EVVQMMPINK QPFSITRLPQ SDPEVAPMSA D
