ID   CTL1_XENLA              Reviewed;         651 AA.
AC   Q6IR74; Q63ZS3;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Choline transporter-like protein 1;
DE   AltName: Full=Solute carrier family 44 member 1;
GN   Name=slc44a1; Synonyms=ctl1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, and Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC       {ECO:0000305}.
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DR   EMBL; BC071026; AAH71026.1; -; mRNA.
DR   EMBL; BC082837; AAH82837.1; -; mRNA.
DR   RefSeq; NP_001085247.1; NM_001091778.1.
DR   AlphaFoldDB; Q6IR74; -.
DR   SMR; Q6IR74; -.
DR   MaxQB; Q6IR74; -.
DR   DNASU; 432345; -.
DR   GeneID; 432345; -.
DR   KEGG; xla:432345; -.
DR   CTD; 432345; -.
DR   Xenbase; XB-GENE-984340; slc44a1.L.
DR   OMA; YCLEKFI; -.
DR   OrthoDB; 329225at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 432345; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015220; F:choline transmembrane transporter activity; ISS:UniProtKB.
DR   InterPro; IPR007603; Choline_transptr-like.
DR   PANTHER; PTHR12385; PTHR12385; 1.
DR   Pfam; PF04515; Choline_transpo; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..651
FT                   /note="Choline transporter-like protein 1"
FT                   /id="PRO_0000359714"
FT   TOPO_DOM        1..25
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..284
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        306..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        333..334
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        356..376
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        398..438
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        460..533
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        534..554
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        555..562
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        563..583
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        584..651
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          629..651
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        176
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        372
FT                   /note="R -> Q (in Ref. 1; AAH71026)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   651 AA;  72937 MW;  A26613B3055420AF CRC64;
     MGCCGSTQNS KRDWRPLEEH SCTDIPWLLL FILFCVGMGF ICGFSIATGA ASRLVFGYDS
     YGNICGQKNT KIEGFINSGL DHSNNKYVFF LDPCKLDLVN RKIKSIALCV SECPREELQT
     LNDVKKFAET NGSALCDYSL TPSQYTTDSR APSLCPKLPV PKSAPIPFFH RCAPVNISCY
     AKFAEALITF VSDNSVLHRL ISGVMTSKEI IMGLCLLSLV LSMILMVIIR YISRVLVWII
     TILVVLGSLG GTGVLWWLYA DNKKSLNENL PPDQLQVSKD NLQALLVYAI AATVFTVILL
     LMMLIMRKRV ALTIALFNVA GKVFIHLPLL VFQPFWTFFA LLLFWVYWVM VLLFLGTAGD
     PFTNEQGFVE FRINGPLQYM WWYHLVGLIW ISEFILACQQ MTIAGAVVTY YFTRNKNDLP
     FTPILASVNR LIRYHLGTVA KGAFIITLVK IPRMILMYIH SQLKGKENAC ARCMLKSCIC
     CLWCLEKCLA YLNQNAYTAT AINSTNFCTS AKDALVILVE NALRVAAINT VGDFMLFLGK
     ILIVSCTGLA GIMLLNYQRD YTVWVLPLII VCLFAFLVAH CFLSIYEMVV DVLFLCFAID
     TKYNDGSPGK EFYMDKVLME FVEDSRRALK EPGSTAEGRE LKPMASGTST A