CTL2A_MOUSE
ID CTL2A_MOUSE Reviewed; 137 AA.
AC P12399; Q91V07;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Protein CTLA-2-alpha;
DE AltName: Full=Cytotoxic T-lymphocyte-associated protein 2-alpha;
DE Flags: Precursor;
GN Name=Ctla2a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/10-BR; TISSUE=T-cell;
RX PubMed=2786470; DOI=10.1002/eji.1830190409;
RA Denizot F., Brunet J.-F., Roustan P., Harper K., Suzan M., Luciani M.-F.,
RA Mattei M.-G., Golstein P.;
RT "Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated
RT T cells and mast cells and homologous to cysteine proteinase proregions.";
RL Eur. J. Immunol. 19:631-635(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA / MRNA].
RC STRAIN=129/SvEvTacfBr, and C57BL/6J; TISSUE=Placenta, and Spleen;
RX PubMed=11829493; DOI=10.1006/geno.2002.6696;
RA Deussing J., Kouadio M., Rehman S., Werber I., Schwinde A., Peters C.;
RT "Identification and characterization of a dense cluster of placenta-
RT specific cysteine peptidase genes and related genes on mouse chromosome
RT 13.";
RL Genomics 79:225-240(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Not known, expressed in activated T-cell.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: To the propeptide regions of cysteine proteases.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA33614.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X15591; CAA33614.1; ALT_INIT; mRNA.
DR EMBL; AY034577; AAK58453.1; -; mRNA.
DR EMBL; AY034580; AAK58456.1; -; Genomic_DNA.
DR EMBL; AK005471; BAB24061.2; -; mRNA.
DR EMBL; AK167433; BAE39520.1; -; mRNA.
DR EMBL; AK167664; BAE39714.1; -; mRNA.
DR EMBL; BC028437; AAH28437.1; -; mRNA.
DR CCDS; CCDS49290.1; -.
DR PIR; S04924; S04924.
DR RefSeq; NP_031822.2; NM_007796.2.
DR AlphaFoldDB; P12399; -.
DR SMR; P12399; -.
DR STRING; 10090.ENSMUSP00000021880; -.
DR MEROPS; I29.002; -.
DR iPTMnet; P12399; -.
DR PhosphoSitePlus; P12399; -.
DR CPTAC; non-CPTAC-3908; -.
DR EPD; P12399; -.
DR MaxQB; P12399; -.
DR PaxDb; P12399; -.
DR PeptideAtlas; P12399; -.
DR PRIDE; P12399; -.
DR ProteomicsDB; 285395; -.
DR DNASU; 13024; -.
DR Ensembl; ENSMUST00000021880; ENSMUSP00000021880; ENSMUSG00000044258.
DR GeneID; 13024; -.
DR KEGG; mmu:13024; -.
DR UCSC; uc007qvx.2; mouse.
DR CTD; 13024; -.
DR MGI; MGI:88554; Ctla2a.
DR VEuPathDB; HostDB:ENSMUSG00000044258; -.
DR eggNOG; KOG1543; Eukaryota.
DR GeneTree; ENSGT00940000153321; -.
DR HOGENOM; CLU_2145035_0_0_1; -.
DR InParanoid; P12399; -.
DR OrthoDB; 1602440at2759; -.
DR PhylomeDB; P12399; -.
DR TreeFam; TF343918; -.
DR BioGRID-ORCS; 13024; 1 hit in 39 CRISPR screens.
DR ChiTaRS; Ctla2a; mouse.
DR PRO; PR:P12399; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; P12399; protein.
DR Bgee; ENSMUSG00000044258; Expressed in decidua and 234 other tissues.
DR ExpressionAtlas; P12399; baseline and differential.
DR Genevisible; P12399; MM.
DR GO; GO:0030425; C:dendrite; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IDA:MGI.
DR GO; GO:0010955; P:negative regulation of protein processing; IMP:MGI.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR GO; GO:0045589; P:regulation of regulatory T cell differentiation; IMP:MGI.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR013201; Prot_inhib_I29.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..137
FT /note="Protein CTLA-2-alpha"
FT /id="PRO_0000026485"
FT REPEAT 39..41
FT /note="1"
FT REPEAT 42..44
FT /note="2"
FT REGION 39..44
FT /note="2 X 3 AA tandem repeats of E-W-K"
FT REGION 114..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 137 AA; 15883 MW; E494B682057C35C9 CRC64;
MMVSICEQKL QHFSAVFLLI LCLGMMSAAP PPDPSLDNEW KEWKTKFAKA YNLNEERHRR
LVWEENKKKI EAHNADYEQG KTSFYMGLNQ FSDLTPEEFK TNCYGNSLNR GEMAPDLPEY
EDLGKNSYLT PGRAQPE
