CTL2B_MOUSE
ID CTL2B_MOUSE Reviewed; 113 AA.
AC P12400; Q3UBK9; Q541S2;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Protein CTLA-2-beta;
DE AltName: Full=Cytotoxic T-lymphocyte-associated protein 2-beta;
GN Name=Ctla2b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/10-BR; TISSUE=T-cell;
RX PubMed=2786470; DOI=10.1002/eji.1830190409;
RA Denizot F., Brunet J.-F., Roustan P., Harper K., Suzan M., Luciani M.-F.,
RA Mattei M.-G., Golstein P.;
RT "Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated
RT T cells and mast cells and homologous to cysteine proteinase proregions.";
RL Eur. J. Immunol. 19:631-635(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA / MRNA].
RC STRAIN=129/SvEvTacfBr, and C57BL/6J; TISSUE=Placenta, and Spleen;
RX PubMed=11829493; DOI=10.1006/geno.2002.6696;
RA Deussing J., Kouadio M., Rehman S., Werber I., Schwinde A., Peters C.;
RT "Identification and characterization of a dense cluster of placenta-
RT specific cysteine peptidase genes and related genes on mouse chromosome
RT 13.";
RL Genomics 79:225-240(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Not known, expressed in activated T-cell.
CC -!- SIMILARITY: To the propeptide regions of cysteine proteases.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK58454.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAK58457.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA33615.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X15592; CAA33615.1; ALT_INIT; mRNA.
DR EMBL; AY034578; AAK58454.1; ALT_INIT; mRNA.
DR EMBL; AY034581; AAK58457.1; ALT_INIT; Genomic_DNA.
DR EMBL; AK150917; BAE29955.1; -; mRNA.
DR CCDS; CCDS49289.1; -.
DR PIR; S04925; S04925.
DR RefSeq; NP_001139273.1; NM_001145801.1.
DR RefSeq; NP_031823.1; NM_007797.1.
DR RefSeq; XP_011242774.1; XM_011244472.1.
DR AlphaFoldDB; P12400; -.
DR SMR; P12400; -.
DR STRING; 10090.ENSMUSP00000021884; -.
DR MEROPS; I29.002; -.
DR MEROPS; I29.008; -.
DR iPTMnet; P12400; -.
DR PhosphoSitePlus; P12400; -.
DR EPD; P12400; -.
DR MaxQB; P12400; -.
DR PaxDb; P12400; -.
DR PeptideAtlas; P12400; -.
DR PRIDE; P12400; -.
DR ProteomicsDB; 277918; -.
DR Ensembl; ENSMUST00000021884; ENSMUSP00000021884; ENSMUSG00000074874.
DR GeneID; 13025; -.
DR KEGG; mmu:13025; -.
DR UCSC; uc007qvt.2; mouse.
DR CTD; 13025; -.
DR MGI; MGI:88555; Ctla2b.
DR VEuPathDB; HostDB:ENSMUSG00000074874; -.
DR eggNOG; KOG1543; Eukaryota.
DR GeneTree; ENSGT00940000153321; -.
DR HOGENOM; CLU_2145035_0_0_1; -.
DR InParanoid; P12400; -.
DR OMA; EWIRWKE; -.
DR OrthoDB; 1536474at2759; -.
DR PhylomeDB; P12400; -.
DR TreeFam; TF343918; -.
DR BioGRID-ORCS; 13025; 0 hits in 50 CRISPR screens.
DR ChiTaRS; Ctla2b; mouse.
DR PRO; PR:P12400; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; P12400; protein.
DR Bgee; ENSMUSG00000074874; Expressed in ectoplacental cone and 49 other tissues.
DR ExpressionAtlas; P12400; baseline and differential.
DR Genevisible; P12400; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; TAS:MGI.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR013201; Prot_inhib_I29.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
PE 4: Predicted;
KW Reference proteome; Repeat.
FT CHAIN 1..113
FT /note="Protein CTLA-2-beta"
FT /id="PRO_0000026486"
FT REPEAT 15..17
FT /note="1"
FT REPEAT 18..20
FT /note="2"
FT REGION 15..20
FT /note="2 X 3 AA tandem repeats of E-W-K"
FT CONFLICT 112..113
FT /note="PE -> V (in Ref. 3; BAE29955)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 113 AA; 13122 MW; 003307762CC5C2C8 CRC64;
MMSAAPSPDP SLDNEWKEWK TTFAKAYSLD EERHRRLMWE ENKKKIEAHN ADYERGKTSF
YMGLNQFSDL TPEEFRTNCC GSSMCRGEMA PDLPEYEDLG KNSYLTPGRA QPE
