CTL2_BOVIN
ID CTL2_BOVIN Reviewed; 706 AA.
AC A5D7H3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Choline transporter-like protein 2;
DE AltName: Full=Solute carrier family 44 member 2;
GN Name=SLC44A2; Synonyms=CTL2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Choline transporter. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with COCH. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
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DR EMBL; BC140554; AAI40555.1; -; mRNA.
DR RefSeq; NP_001091608.1; NM_001098139.1.
DR AlphaFoldDB; A5D7H3; -.
DR STRING; 9913.ENSBTAP00000003403; -.
DR PaxDb; A5D7H3; -.
DR PRIDE; A5D7H3; -.
DR Ensembl; ENSBTAT00000003403; ENSBTAP00000003403; ENSBTAG00000002628.
DR GeneID; 617624; -.
DR KEGG; bta:617624; -.
DR CTD; 57153; -.
DR VEuPathDB; HostDB:ENSBTAG00000002628; -.
DR VGNC; VGNC:34876; SLC44A2.
DR eggNOG; KOG1362; Eukaryota.
DR GeneTree; ENSGT00940000158178; -.
DR HOGENOM; CLU_017181_3_1_1; -.
DR InParanoid; A5D7H3; -.
DR OrthoDB; 329225at2759; -.
DR TreeFam; TF313325; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000002628; Expressed in lung and 105 other tissues.
DR ExpressionAtlas; A5D7H3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015220; F:choline transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015871; P:choline transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..706
FT /note="Choline transporter-like protein 2"
FT /id="PRO_0000327934"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..315
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..364
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 386..457
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 481..504
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 526..563
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 585..599
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 600..620
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 621..638
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 660..706
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 14
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWA5"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 397
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 417
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 706 AA; 80027 MW; 7A8DD0420E89EF81 CRC64;
MGKEQQLYYG KHGTPQKYDP AFRGPIYNRG CTDIICCVFL FLAIVGYVAV GIIAWTHGDP
RKVIYPTDSR GQFCGQKGTK NENKPFLFYF NIVKCASPLV LLEFQCPTPQ ICVEKCPSRY
LTYLNAHASE DFEYYKQYCL PGFQKNKGVA EVLRDGDCPA VLIPSKPFAQ RCFPAVHAHK
GILMVGNETT YEDGLGSRKN ITELVEGAKK ASGILEARQL AMRIFEDYTV SWYWIIIGLI
IAMVLSLLFI ILLRFLAGIM VWVMIVMVIL VLGYGILHCY MEYARLRGEA GSDVSLVDLG
FQTDFRVYLH LRQTWVAFMI ILSIVEVIII LLLIFLRKRI LIAIALIKEA SRAVGYVMCS
LLYPLVTFFL LCLCIAYWAS TAIFLSTSNE AVYKIFNETS CPVAGKTCNP ETFPSSNESR
LCPGAHCQFA FYGGESTYHR ALLGLQIFNV FMFFWLANFV LALGQVTLAG AFASYYWAMN
KPDDLPAFPL FSAFGRALRY HTGSLAFGSL LLAIVQVIRV ILEYLDQRLK AAENKFAKFL
MSCLKCCFWC LEKFIKFLNR NAYIMIAIYG TNFCTSARNA FFLLMRNIIR VAVLDKVTDF
LFLLGKLLIV GSVGILAFFF FTHRIRIVQD TAPSLNYYWV PVVTVVIGSY LIAHGFFSVY
GMCVDTLFLC FLEDLERNDG TPERPYFMSL TLKKILNKTN KRQAEA
