CTL2_DANRE
ID CTL2_DANRE Reviewed; 697 AA.
AC Q7SYC9;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Choline transporter-like protein 2;
DE AltName: Full=Solute carrier family 44 member 2;
GN Name=slc44a2; Synonyms=ctl2; ORFNames=zgc:63569;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Choline transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
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DR EMBL; BC054915; AAH54915.1; -; mRNA.
DR RefSeq; NP_942572.1; NM_198871.1.
DR AlphaFoldDB; Q7SYC9; -.
DR STRING; 7955.ENSDARP00000023293; -.
DR PaxDb; Q7SYC9; -.
DR GeneID; 321056; -.
DR KEGG; dre:321056; -.
DR ZFIN; ZDB-GENE-030131-9816; zgc:63569.
DR eggNOG; KOG1362; Eukaryota.
DR InParanoid; Q7SYC9; -.
DR OrthoDB; 329225at2759; -.
DR PhylomeDB; Q7SYC9; -.
DR PRO; PR:Q7SYC9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015220; F:choline transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015871; P:choline transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..697
FT /note="Choline transporter-like protein 2"
FT /id="PRO_0000359716"
FT TOPO_DOM 1..30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..226
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 331..353
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 375..435
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 457..498
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 520..593
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 594..614
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 615..632
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 633..653
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 654..697
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 287
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 391
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 406
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 697 AA; 79178 MW; CF25E70BCF0B9E18 CRC64;
MDMEEKPKYG EPRKFDPSFK GPIQNRGCTD IVCCIIFIIA ILGYLAVGIL AWTHGDPRKV
IYPTDSMGQF CGQGKLEKQP FLFYFNMMKC ASPMVLLEFQ CPTPQVCVQT CPNRTMTLIT
AISKPQDWEY YKSYCKEDPG HKAAAQILKE KLCPAYLVSS NPFLQRCFPS MGKKGEVITV
GDQEKFSDGV NVLDAKDLMA GMKNASIVME GRQVAMKIFE DYTKSWYWIL ICLLIAVVLS
LIFIVLLRFL AGVMVWVMIL MVVAVIAYGI AHCSIKYVSL KDTPGSNITL QQLGFQPDFA
VYLHIRQTWL AFIIILAILE LIIILLLIFL RNRIRVAVEL MKEASRAIGY VMSSLVFPIF
TFFLLAIVIA FWGVNAVFLS TSSEPVYKVF NETECVHSRE TCNPENFTSS SMKSDCPHSQ
CLFAFYGGET PYHKYLILLQ FYNVFLFFWC ANFVTALGQM TLAGAFASYY WAFDKSKDMP
AFPLCASLGR SLRYHTGSLA FGSLLLAIVQ VIRVLLEYID HKLKGAENKF AKFLLCCLKC
CFWCLEKFIK FINRNAYIMV AIYGKNFCRS ARDAFFLLMR NVVRVVVLDK VTDFILFLGK
LLIVGLVGIF AFFFFSGQTD AFKGTAPSLH YYWVPILTVL VCSYLIAHGF FSVYAMCVDT
LFLCFLEDLE RNDGSAERPY LMSENLLNVL KKKNQAN
