CTL2_HUMAN
ID CTL2_HUMAN Reviewed; 706 AA.
AC Q8IWA5; B2RBB1; B3KNH3; B4DFJ0; F2Q9D7; Q658V1; Q658Z2; Q6PJV7; Q8N2F0;
AC Q9NY68;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Choline transporter-like protein 2;
DE AltName: Full=Solute carrier family 44 member 2;
GN Name=SLC44A2; Synonyms=CTL2; ORFNames=PSEC0210;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1),
RP FUNCTION, AND VARIANT ARG-154.
RX PubMed=10677542; DOI=10.1073/pnas.030339697;
RA O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M.;
RT "An electric lobe suppressor for a yeast choline transport mutation belongs
RT to a new family of transporter-like proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE, TISSUE SPECIFICITY, AND
RP VARIANT ARG-154.
RC TISSUE=Epithelium, and Inner ear;
RX PubMed=14973250; DOI=10.1523/jneurosci.5063-03.2004;
RA Nair T.S., Kozma K.E., Hoefling N.L., Kommareddi P.K., Ueda Y., Gong T.-W.,
RA Lomax M.I., Lansford C.D., Telian S.A., Satar B., Arts H.A.,
RA El-Kashlan H.K., Berryhill W.E., Raphael Y., Carey T.E.;
RT "Identification and characterization of choline transporter-like protein 2,
RT an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-
RT induced hearing loss.";
RL J. Neurosci. 24:1772-1779(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Santoso S.S., Bayat B.B., Sachs U.;
RT "Detection of HNA-3b antibodies in patient sera.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 565-706 (ISOFORM 2), AND VARIANT ARG-154.
RC TISSUE=Brain cortex, Placenta, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-154.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-154.
RC TISSUE=Eye, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-706 (ISOFORM 1), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 273-706 (ISOFORM 2), AND VARIANT ARG-154.
RC TISSUE=Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 321-706 (ISOFORM 1).
RC TISSUE=Embryo;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 663-706 (ISOFORM 3).
RA Yu W., Gibbs R.A.;
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP INTERACTION WITH COCH.
RX PubMed=17926100; DOI=10.1007/s10162-007-0099-2;
RA Kommareddi P.K., Nair T.S., Raphael Y., Telian S.A., Kim A.H., Arts H.A.,
RA El-Kashlan H.K., Carey T.E.;
RT "Cochlin isoforms and their interaction with CTL2 (SLC44A2) in the inner
RT ear.";
RL J. Assoc. Res. Otolaryngol. 8:435-446(2007).
RN [12]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-187 AND ASN-200.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of multiple
RT enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [13]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-187 AND ASN-200.
RC TISSUE=Leukemic T-cell;
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-linked
RT cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
RN [14]
RP FUNCTION, ALTERNATIVE PROMOTER USAGE, AND TISSUE SPECIFICITY.
RX PubMed=20665236; DOI=10.1007/s10930-010-9268-y;
RA Kommareddi P.K., Nair T.S., Thang L.V., Galano M.M., Babu E., Ganapathy V.,
RA Kanazawa T., McHugh J.B., Carey T.E.;
RT "Isoforms, expression, glycosylation, and tissue distribution of
RT CTL2/SLC44A2.";
RL Protein J. 29:417-426(2010).
RN [15]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [16]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: Isoform 1, but not isoform 3, exhibits some choline
CC transporter activity. {ECO:0000269|PubMed:10677542,
CC ECO:0000269|PubMed:20665236}.
CC -!- SUBUNIT: Interacts with COCH. {ECO:0000269|PubMed:17926100}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage, Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=CTL2a, CTL2P2A;
CC IsoId=Q8IWA5-1; Sequence=Displayed;
CC Name=2; Synonyms=CTL2b, CTL2P2B;
CC IsoId=Q8IWA5-2; Sequence=VSP_015431;
CC Name=3; Synonyms=CTL2P1;
CC IsoId=Q8IWA5-3; Sequence=VSP_041792;
CC -!- TISSUE SPECIFICITY: Present in supporting cells of the inner ear (at
CC protein level). Only isoform 3 is expressed in inner ear vestibular
CC tissue. {ECO:0000269|PubMed:14973250, ECO:0000269|PubMed:20665236}.
CC -!- MISCELLANEOUS: [Isoform 3]: Produced by alternative promoter usage.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC11662.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AJ245621; CAB75542.1; -; Genomic_DNA.
DR EMBL; FN668568; CBJ93592.1; -; mRNA.
DR EMBL; AK027519; BAG51335.1; -; mRNA.
DR EMBL; AK294118; BAG57451.1; -; mRNA.
DR EMBL; AK314582; BAG37158.1; -; mRNA.
DR EMBL; AC011475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471106; EAW84126.1; -; Genomic_DNA.
DR EMBL; BC010617; AAH10617.1; -; mRNA.
DR EMBL; BC040556; AAH40556.1; -; mRNA.
DR EMBL; AL832517; CAH56352.1; -; mRNA.
DR EMBL; AL832978; CAH56342.1; -; mRNA.
DR EMBL; AK075512; BAC11662.1; ALT_INIT; mRNA.
DR EMBL; AF070636; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS12245.1; -. [Q8IWA5-1]
DR CCDS; CCDS54216.1; -. [Q8IWA5-3]
DR CCDS; CCDS86700.1; -. [Q8IWA5-2]
DR RefSeq; NP_001138528.1; NM_001145056.1. [Q8IWA5-3]
DR RefSeq; NP_065161.3; NM_020428.3. [Q8IWA5-1]
DR RefSeq; XP_005260054.1; XM_005259997.1.
DR AlphaFoldDB; Q8IWA5; -.
DR SMR; Q8IWA5; -.
DR BioGRID; 121410; 14.
DR IntAct; Q8IWA5; 10.
DR MINT; Q8IWA5; -.
DR STRING; 9606.ENSP00000336888; -.
DR DrugBank; DB00122; Choline.
DR TCDB; 2.A.92.1.4; the choline transporter-like (ctl) family.
DR GlyConnect; 1111; 12 N-Linked glycans (2 sites).
DR GlyGen; Q8IWA5; 4 sites, 12 N-linked glycans (2 sites), 1 O-linked glycan (1 site).
DR iPTMnet; Q8IWA5; -.
DR PhosphoSitePlus; Q8IWA5; -.
DR SwissPalm; Q8IWA5; -.
DR BioMuta; SLC44A2; -.
DR DMDM; 311033462; -.
DR EPD; Q8IWA5; -.
DR jPOST; Q8IWA5; -.
DR MassIVE; Q8IWA5; -.
DR MaxQB; Q8IWA5; -.
DR PaxDb; Q8IWA5; -.
DR PeptideAtlas; Q8IWA5; -.
DR PRIDE; Q8IWA5; -.
DR ProteomicsDB; 70829; -. [Q8IWA5-1]
DR ProteomicsDB; 70830; -. [Q8IWA5-2]
DR ProteomicsDB; 70831; -. [Q8IWA5-3]
DR Antibodypedia; 1011; 137 antibodies from 24 providers.
DR DNASU; 57153; -.
DR Ensembl; ENST00000335757.10; ENSP00000336888.4; ENSG00000129353.15. [Q8IWA5-1]
DR Ensembl; ENST00000407327.8; ENSP00000385135.3; ENSG00000129353.15. [Q8IWA5-3]
DR Ensembl; ENST00000586078.5; ENSP00000466664.1; ENSG00000129353.15. [Q8IWA5-2]
DR GeneID; 57153; -.
DR KEGG; hsa:57153; -.
DR MANE-Select; ENST00000335757.10; ENSP00000336888.4; NM_020428.4; NP_065161.3.
DR UCSC; uc002mpe.5; human. [Q8IWA5-1]
DR CTD; 57153; -.
DR DisGeNET; 57153; -.
DR GeneCards; SLC44A2; -.
DR HGNC; HGNC:17292; SLC44A2.
DR HPA; ENSG00000129353; Low tissue specificity.
DR MIM; 606106; gene.
DR neXtProt; NX_Q8IWA5; -.
DR OpenTargets; ENSG00000129353; -.
DR PharmGKB; PA142670899; -.
DR VEuPathDB; HostDB:ENSG00000129353; -.
DR eggNOG; KOG1362; Eukaryota.
DR GeneTree; ENSGT00940000158178; -.
DR HOGENOM; CLU_017181_3_1_1; -.
DR InParanoid; Q8IWA5; -.
DR OMA; CIAYWAC; -.
DR OrthoDB; 329225at2759; -.
DR PhylomeDB; Q8IWA5; -.
DR TreeFam; TF313325; -.
DR PathwayCommons; Q8IWA5; -.
DR Reactome; R-HSA-1483191; Synthesis of PC.
DR Reactome; R-HSA-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; Q8IWA5; -.
DR SIGNOR; Q8IWA5; -.
DR BioGRID-ORCS; 57153; 10 hits in 1089 CRISPR screens.
DR ChiTaRS; SLC44A2; human.
DR GeneWiki; SLC44A2; -.
DR GenomeRNAi; 57153; -.
DR Pharos; Q8IWA5; Tbio.
DR PRO; PR:Q8IWA5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8IWA5; protein.
DR Bgee; ENSG00000129353; Expressed in tibial nerve and 182 other tissues.
DR ExpressionAtlas; Q8IWA5; baseline and differential.
DR Genevisible; Q8IWA5; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; TAS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; HDA:UniProtKB.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:ARUK-UCL.
DR GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0035579; C:specific granule membrane; TAS:Reactome.
DR GO; GO:0015220; F:choline transmembrane transporter activity; IDA:ARUK-UCL.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015871; P:choline transport; IDA:ARUK-UCL.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; TAS:Reactome.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; HMP:UniProtKB.
DR GO; GO:0055085; P:transmembrane transport; IDA:ARUK-UCL.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 1: Evidence at protein level;
KW Alternative promoter usage; Alternative splicing; Glycoprotein; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..706
FT /note="Choline transporter-like protein 2"
FT /id="PRO_0000191717"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..315
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..364
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 386..457
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 458..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 481..504
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 526..563
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 585..599
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 600..620
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 621..638
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 660..706
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 14
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218,
FT ECO:0000269|PubMed:19349973"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218,
FT ECO:0000269|PubMed:19349973"
FT CARBOHYD 417
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..12
FT /note="MGDERPHYYGKH -> MEDERKNGAY (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.10"
FT /id="VSP_041792"
FT VAR_SEQ 672..706
FT /note="LEDLERNDGSAERPYFMSSTLKKLLNKTNKKAAES -> CEDLERNDGSQER
FT PYFMSPELRDILLKGSAEEGKRAEAEE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_015431"
FT VARIANT 154
FT /note="Q -> R (in dbSNP:rs2288904)"
FT /evidence="ECO:0000269|PubMed:10677542,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:14973250,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005,
FT ECO:0000269|Ref.6"
FT /id="VAR_023404"
FT CONFLICT 92
FT /note="I -> T (in Ref. 4; BAG51335)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="L -> F (in Ref. 3; CBJ93592)"
FT /evidence="ECO:0000305"
FT CONFLICT 531
FT /note="A -> G (in Ref. 1; CAB75542)"
FT /evidence="ECO:0000305"
FT CONFLICT 695
FT /note="L -> P (in Ref. 7; AAH40556)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 706 AA; 80124 MW; 9A044A531930326E CRC64;
MGDERPHYYG KHGTPQKYDP TFKGPIYNRG CTDIICCVFL LLAIVGYVAV GIIAWTHGDP
RKVIYPTDSR GEFCGQKGTK NENKPYLFYF NIVKCASPLV LLEFQCPTPQ ICVEKCPDRY
LTYLNARSSR DFEYYKQFCV PGFKNNKGVA EVLQDGDCPA VLIPSKPLAR RCFPAIHAYK
GVLMVGNETT YEDGHGSRKN ITDLVEGAKK ANGVLEARQL AMRIFEDYTV SWYWIIIGLV
IAMAMSLLFI ILLRFLAGIM VWVMIIMVIL VLGYGIFHCY MEYSRLRGEA GSDVSLVDLG
FQTDFRVYLH LRQTWLAFMI ILSILEVIII LLLIFLRKRI LIAIALIKEA SRAVGYVMCS
LLYPLVTFFL LCLCIAYWAS TAVFLSTSNE AVYKIFDDSP CPFTAKTCNP ETFPSSNESR
QCPNARCQFA FYGGESGYHR ALLGLQIFNA FMFFWLANFV LALGQVTLAG AFASYYWALR
KPDDLPAFPL FSAFGRALRY HTGSLAFGAL ILAIVQIIRV ILEYLDQRLK AAENKFAKCL
MTCLKCCFWC LEKFIKFLNR NAYIMIAIYG TNFCTSARNA FFLLMRNIIR VAVLDKVTDF
LFLLGKLLIV GSVGILAFFF FTHRIRIVQD TAPPLNYYWV PILTVIVGSY LIAHGFFSVY
GMCVDTLFLC FLEDLERNDG SAERPYFMSS TLKKLLNKTN KKAAES
