CTL2_PIG
ID CTL2_PIG Reviewed; 706 AA.
AC F1S584;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Choline transporter-like protein 2;
DE AltName: Full=Solute carrier family 44 member 2;
GN Name=SLC44A2; Synonyms=CTL2;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Choline transporter. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with COCH. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
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DR EMBL; CU993813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003123258.1; XM_003123210.3.
DR AlphaFoldDB; F1S584; -.
DR SMR; F1S584; -.
DR STRING; 9823.ENSSSCP00000014493; -.
DR PaxDb; F1S584; -.
DR PeptideAtlas; F1S584; -.
DR PRIDE; F1S584; -.
DR Ensembl; ENSSSCT00015098292; ENSSSCP00015040450; ENSSSCG00015067234.
DR Ensembl; ENSSSCT00030037402; ENSSSCP00030017118; ENSSSCG00030026479.
DR Ensembl; ENSSSCT00035035754; ENSSSCP00035014194; ENSSSCG00035026908.
DR Ensembl; ENSSSCT00040005600; ENSSSCP00040002097; ENSSSCG00040004220.
DR Ensembl; ENSSSCT00045042331; ENSSSCP00045029382; ENSSSCG00045023968.
DR Ensembl; ENSSSCT00070045933; ENSSSCP00070038733; ENSSSCG00070022938.
DR GeneID; 100524730; -.
DR KEGG; ssc:100524730; -.
DR CTD; 57153; -.
DR eggNOG; KOG1362; Eukaryota.
DR HOGENOM; CLU_017181_3_1_1; -.
DR InParanoid; F1S584; -.
DR TreeFam; TF313325; -.
DR Reactome; R-SSC-1483191; Synthesis of PC.
DR Reactome; R-SSC-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR Reactome; R-SSC-6798695; Neutrophil degranulation.
DR ChiTaRS; SLC44A2; pig.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Chromosome 2.
DR Genevisible; F1S584; SS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015220; F:choline transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015871; P:choline transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..706
FT /note="Choline transporter-like protein 2"
FT /id="PRO_0000412768"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..315
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..364
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 386..440
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 462..504
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 526..563
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 585..599
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 600..620
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 621..638
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 660..706
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 14
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWA5"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 706 AA; 80238 MW; 44A9545C08DA3FD8 CRC64;
MGGERQHYYG KHGTPQKYDP TFKGPIYHRG CTDVICCVFL LLAIVGYVAV GIIAWTHGDP
RKVIYPTDSR GEFCGQKGTK NANKSYLFYF NIVKCASPLV LLEFQCPTPQ ICVEKCPNRY
LTYLKAHGTQ EFEYYKQFCV PGFKQNKAVT EVLRDGDCPA VLIPSKPLVQ RCFPAIHAHK
GVLMVGNETS YEDGHGFRKN ITDLVEGAKK ANGILEARHL AMRIFEDYTV SWYWIIIGLV
IAMVLSLLFI ILLRFLAGIM VWVMIVMVIL VLGYGIFHCY MEYSRLRGEA GSDISLVDLG
FQTDLRVYLH LRQTWMAFMI ILSILEVIII LLLIFLRKRI LIAIALIKEA SRAVGYVMCS
MLYPLVTFLL LCLCIAYWAS TAIFLSTSNE AVYKIFSDTD CQAVGKTCNP ENFSSSSEFH
LCPGAHCQFA FYGGESTYHR ALLGLQIFNA FMFFWLANFV LALGQVTLAG AFASYYWALK
KPDDLPAFPL FSAFGRALRY HTGSLAFGSL LLAIVQIIRV MLEYLDQRLK AAENKFAKFL
MTCLKCCFWC LEKFIKFLNR NAYIMIAIYG TNFCTSARNA FFLLMRNIIR VAVLDKVTDF
LFLLGKLLIV GSVGILAFFF FTHRIRIVQD TAPPLNYYWV PILTVIVGSY LIAHGFFSVY
GMCVDTLFLC FLEDLERNDG SMERPYFMSP TLKRLLNKTN RKPAES
