CTL2_RAT
ID CTL2_RAT Reviewed; 705 AA.
AC B4F795;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Choline transporter-like protein 2;
DE AltName: Full=Solute carrier family 44 member 2;
GN Name=Slc44a2; Synonyms=Ctl2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Choline transporter. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with COCH. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
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DR EMBL; CH473993; EDL78302.1; -; Genomic_DNA.
DR EMBL; BC168183; AAI68183.1; -; mRNA.
DR RefSeq; NP_001128187.1; NM_001134715.1.
DR AlphaFoldDB; B4F795; -.
DR BioGRID; 263910; 2.
DR STRING; 10116.ENSRNOP00000051322; -.
DR GlyGen; B4F795; 3 sites, 2 N-linked glycans (1 site).
DR SwissPalm; B4F795; -.
DR PaxDb; B4F795; -.
DR PeptideAtlas; B4F795; -.
DR PRIDE; B4F795; -.
DR GeneID; 363024; -.
DR KEGG; rno:363024; -.
DR UCSC; RGD:1309680; rat.
DR CTD; 57153; -.
DR RGD; 1309680; Slc44a2.
DR VEuPathDB; HostDB:ENSRNOG00000031824; -.
DR eggNOG; KOG1362; Eukaryota.
DR HOGENOM; CLU_017181_3_1_1; -.
DR InParanoid; B4F795; -.
DR OMA; CIAYWAC; -.
DR OrthoDB; 329225at2759; -.
DR PhylomeDB; B4F795; -.
DR Reactome; R-RNO-1483191; Synthesis of PC.
DR Reactome; R-RNO-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR Reactome; R-RNO-6798695; Neutrophil degranulation.
DR PRO; PR:B4F795; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Proteomes; UP000234681; Chromosome 8.
DR Bgee; ENSRNOG00000031824; Expressed in spleen and 20 other tissues.
DR Genevisible; B4F795; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0015220; F:choline transmembrane transporter activity; ISO:RGD.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015871; P:choline transport; ISO:RGD.
DR GO; GO:0055085; P:transmembrane transport; ISO:RGD.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..705
FT /note="Choline transporter-like protein 2"
FT /id="PRO_0000359715"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..315
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..364
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 386..453
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 477..503
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 504..524
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 525..562
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 563..583
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 584..598
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 599..619
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 620..637
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 638..658
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 659..705
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 14
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWA5"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 416
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 705 AA; 79897 MW; 1ADF61887F826F52 CRC64;
MGKDSQHYYG KHGTPQKYDP TFKGPIYNRG CTDIICCVLL FLAIVGYVAV GIIAWTHGDP
RKVIYPTDSR GEFCGQKGTK NADKPFLFYF NIVKCASPLV LLEFHCPTPQ ICVKQCPDRY
LTFLSARNSR DFDYYKQFCV PGFKNNKGVA EVLRDGECPA VIIPSKPLAQ RCFPAIHASK
GVLMVGNETT YEDGHGTRKN VTDLVEGAKK ANKVLEARQL AMQIFEDYTV SWYWIVIGLV
IAMLLSLMFI VLLRFLAGVM VWVMIVMVIL VLGYGIFHCY AEYSRLRGEA GSDVSLVDLG
FQTDLRVYLH LRQTWMAFMI ILSILEVVII LLLIFLRKRI LIAIALIKEA SRAVGHVMCS
MLYPLVTFFL LCLCIAYWAS TSVFLSTSNV AVYKIVDDTP CPLLGKTCNP ETFPLNESRQ
CPNGRCQFAF YGGESTYHRA LLGLQIFNAF MFFWLANFVL ALGQVTLAGA FASYYWAMRK
PDDMPAFPLF SAFGRALRYH TGSLAFGSLI LAIVQIIRVM LEYLDQRLKA AQNKFAKFLM
VCLKCCFWCL EKFIKFLNRN AYIMIAIYGT NFCTSARNAF FLLMRNIIRV AVLDKVTDFL
FLLGKLLIVG SVGILAFFFF THRIRIVQDT APPLNYYWVP ILTVIIGSYL IAHGFFSVYG
MCVDTLFLCF LEDLERNDGS AERPYFMSST LKKLLNKTNK KVAES
