CTL2_SALSA
ID CTL2_SALSA Reviewed; 706 AA.
AC B5X3W7;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 39.
DE RecName: Full=Choline transporter-like protein 2;
DE AltName: Full=Solute carrier family 44 member 2;
GN Name=slc44a2; Synonyms=ctl2;
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BT045736; ACI33998.1; -; mRNA.
DR RefSeq; NP_001133839.1; NM_001140367.1.
DR AlphaFoldDB; B5X3W7; -.
DR GeneID; 100195338; -.
DR KEGG; sasa:100195338; -.
DR CTD; 110281; -.
DR Proteomes; UP000087266; Chromosome ssa06.
DR Bgee; ENSSSAG00000047269; Expressed in nose and 13 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..706
FT /note="Choline transporter-like protein 2"
FT /id="PRO_0000359717"
FT TOPO_DOM 1..32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..315
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..364
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 386..454
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 478..504
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 526..599
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 600..620
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 621..638
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 639..659
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 660..706
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 293
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 397
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 412
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 706 AA; 79994 MW; 96B5B40B0188E01E CRC64;
MMELEGEKPN YGEPRKYDPT FKGPIYNRGC TDIVCCIFFI ICILGYVAVG ILAWSQGDPR
KVIYPTDSRG QFCGQAGTPL ETKPLLFYFN IMKCASPMVL LEFQCPTTQM CVEKCPDKFM
TLLKAYANKE DFKYYKNFCK EGLEGLTVTQ ILSSGLCPAM LTPSKPFTRR CFPALDQKKG
GEITVGNNSK FDDGEGNIRD AKDLVAGVKN ATVVIEARQV VMKIFEDYTQ SWYWILIGLV
IAMLISLLFI VLLRFLAGIM VWVMIVMVIL VIGYGIFHCS MEYVSLKSEA GSNVTLKDLG
FQTDFSVYLH IRQTWLAFII ILAIVEVVII LLLIFLRNRI LIAIALIKEA SRAIGYVMSA
LFYPLFTFAL LSIVIAYWAV TAVFLSTSNQ PIYKVFNDTA CDHSRKICEP ANFSTSSMKA
ECPDSKCLFA FYGGETVYHK YLIGLQFYNV FLFFWCANFV TALGQMTLAG AFASYYWALV
KPDDMPAFPI FSSLGRSLRY HTGSLAFGSL ILSIIQIIRV LLEYIDHKLQ GTQNKCTKFL
LCCLKCCFWC LEKFIKFINR NAYIMVAIYG KNFCTSAKDA FFLLMRNMIR VAVLDKVTDF
LLFLGKLLIV GLVGIFAFFF FSGRVKAFEN TAPNLHYYWV PILTVVVGSY LIAHGFFSVY
AMCVDTLFLC FLEDLERNDG SAERPYLMSD RLLKVLNKKN KPEPAE
