ID   CTL2_XENLA              Reviewed;         710 AA.
AC   Q6IP59;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Choline transporter-like protein 2;
DE   AltName: Full=Solute carrier family 44 member 2;
GN   Name=slc44a2; Synonyms=ctl2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC       {ECO:0000305}.
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DR   EMBL; BC072059; AAH72059.1; -; mRNA.
DR   RefSeq; NP_001085138.1; NM_001091669.1.
DR   AlphaFoldDB; Q6IP59; -.
DR   DNASU; 432216; -.
DR   GeneID; 432216; -.
DR   KEGG; xla:432216; -.
DR   CTD; 432216; -.
DR   Xenbase; XB-GENE-957801; slc44a2.L.
DR   OrthoDB; 329225at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 432216; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR007603; Choline_transptr-like.
DR   PANTHER; PTHR12385; PTHR12385; 1.
DR   Pfam; PF04515; Choline_transpo; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..710
FT                   /note="Choline transporter-like protein 2"
FT                   /id="PRO_0000359718"
FT   TOPO_DOM        1..34
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        56..236
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..260
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        282..319
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        341..368
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        390..458
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        459..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        482..508
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        509..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        530..567
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        568..588
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        589..603
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        604..624
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        625..642
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        643..663
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        664..710
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        147
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        190
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        204
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        401
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        418
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        421
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   710 AA;  80693 MW;  1EE9EA5BD81AA35B CRC64;
     MEDDGKSPPD SAYGEPKKYD PNFKGPIQNR GCTDILCCIL IVLGIIAYVA VGIVAWTYGD
     PRKVIYPTDS KGQFCGQVGT PNEKKPFLFY FNIMKCASPL VLLQFQCPTT QICVENCPDR
     FLTYLSVATT QQNFDYYKQF CRDGFNNFTK SPVEVLRDRD CPAMITPSKP FTRRCFPAIN
     TQKGVVMVGN STTFDDGRGD KQRNVTDLLE GAKKANVVLE ARQVAMKIFE DYTVSWYWII
     IGLIIAMVIS LIFVVLLRFL AGIMVWVMIV LVIAVMGYGI FHCYMEYARL KGQSGSDVTL
     KDIGFQTDIR VYLHLRQTWL AFMIILCILE VIVILLLIFL RKRIMIAIAL IKEASRAVGF
     VMSSLVFPLF TFLLVCLCIA YWAITAVFLS TSNEAVYKVF NETQCDFSGN TCNPETFNTT
     NVTRVCPDAT CQFAFYGGET YYHKYLIVFQ IYNAFMFLWL ANFVIALGQV TLAGAFASYY
     WAFKKPDDMP AFPIFSSLGR ALRYHTGSLA FGSLILAIVQ MIRILLEYLD HKLKGADNKC
     ARFLLCCLKC CFWCLEKFIK FLNRNAYIMI AIYGTNFCTS ARNAFFLLMR NIIRVAVLDK
     VTDFLLFLGK LLVVGCVGIL AFFFFSRRIQ IVQDTAPTLN YYWVPILTVI LGSYLIAHGF
     FSVYGMCVDT LFLCFLEDLE RNDGSTERPY FMSGSLQKLL NKSNQTKPDK