CTL3_HUMAN
ID CTL3_HUMAN Reviewed; 653 AA.
AC Q8N4M1; B4DVY4; B4E1M4; B7ZA08; E9PJH2; E9PJY8; Q6UWT1; Q7Z6C5; Q9BWY7;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 4.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Choline transporter-like protein 3;
DE AltName: Full=Solute carrier family 44 member 3;
GN Name=SLC44A3; Synonyms=CTL3; ORFNames=UNQ558/PRO1115;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5), AND VARIANT
RP ILE-438.
RC TISSUE=Colon, Stomach, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ILE-438.
RC TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 147-653.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP IDENTIFICATION, AND NOMENCLATURE.
RX PubMed=10677542; DOI=10.1073/pnas.030339697;
RA O'Regan S., Traiffort E., Ruat M., Cha N., Compaore D., Meunier F.-M.;
RT "An electric lobe suppressor for a yeast choline transport mutation belongs
RT to a new family of transporter-like proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000).
RN [6]
RP VARIANT TRP-441.
RX PubMed=21248752; DOI=10.1038/nature09639;
RA Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H.,
RA Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J.,
RA Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M.,
RA Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L.,
RA Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J.,
RA Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A.,
RA Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K.,
RA Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.;
RT "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene
RT PBRM1 in renal carcinoma.";
RL Nature 469:539-542(2011).
CC -!- INTERACTION:
CC Q8N4M1; Q13643: FHL3; NbExp=3; IntAct=EBI-10265585, EBI-741101;
CC Q8N4M1-3; Q8WTS1: ABHD5; NbExp=3; IntAct=EBI-12056955, EBI-2813554;
CC Q8N4M1-3; O14732: IMPA2; NbExp=3; IntAct=EBI-12056955, EBI-725233;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q8N4M1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N4M1-2; Sequence=VSP_036151;
CC Name=3;
CC IsoId=Q8N4M1-3; Sequence=VSP_036152;
CC Name=4;
CC IsoId=Q8N4M1-4; Sequence=VSP_036152, VSP_044713;
CC Name=5;
CC IsoId=Q8N4M1-5; Sequence=VSP_036151, VSP_044713, VSP_045974;
CC Name=6;
CC IsoId=Q8N4M1-6; Sequence=VSP_044713, VSP_045974;
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH33858.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAQ89022.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK303906; BAG64836.1; -; mRNA.
DR EMBL; AK301288; BAG62846.1; -; mRNA.
DR EMBL; AK316123; BAH14494.1; -; mRNA.
DR EMBL; AC093429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL359554; CAC36091.1; -; Genomic_DNA.
DR EMBL; BC033858; AAH33858.2; ALT_INIT; mRNA.
DR EMBL; BC053877; AAH53877.1; -; mRNA.
DR EMBL; AY358659; AAQ89022.1; ALT_INIT; mRNA.
DR CCDS; CCDS44176.1; -. [Q8N4M1-1]
DR CCDS; CCDS58011.1; -. [Q8N4M1-6]
DR CCDS; CCDS58012.1; -. [Q8N4M1-4]
DR CCDS; CCDS58013.1; -. [Q8N4M1-3]
DR CCDS; CCDS751.1; -. [Q8N4M1-2]
DR RefSeq; NP_001107578.1; NM_001114106.2. [Q8N4M1-1]
DR RefSeq; NP_001245269.1; NM_001258340.1.
DR RefSeq; NP_001245270.1; NM_001258341.1. [Q8N4M1-6]
DR RefSeq; NP_001245271.1; NM_001258342.1. [Q8N4M1-3]
DR RefSeq; NP_001245272.1; NM_001258343.1. [Q8N4M1-4]
DR RefSeq; NP_001288008.1; NM_001301079.1.
DR RefSeq; NP_689582.2; NM_152369.4. [Q8N4M1-2]
DR RefSeq; XP_005270498.1; XM_005270441.2. [Q8N4M1-2]
DR AlphaFoldDB; Q8N4M1; -.
DR BioGRID; 126026; 50.
DR IntAct; Q8N4M1; 3.
DR STRING; 9606.ENSP00000271227; -.
DR DrugBank; DB00122; Choline.
DR DrugBank; DB14006; Choline salicylate.
DR TCDB; 2.A.92.1.3; the choline transporter-like (ctl) family.
DR GlyGen; Q8N4M1; 5 sites.
DR iPTMnet; Q8N4M1; -.
DR PhosphoSitePlus; Q8N4M1; -.
DR BioMuta; SLC44A3; -.
DR DMDM; 259016387; -.
DR EPD; Q8N4M1; -.
DR jPOST; Q8N4M1; -.
DR MassIVE; Q8N4M1; -.
DR MaxQB; Q8N4M1; -.
DR PaxDb; Q8N4M1; -.
DR PeptideAtlas; Q8N4M1; -.
DR PRIDE; Q8N4M1; -.
DR ProteomicsDB; 21138; -.
DR ProteomicsDB; 21290; -.
DR ProteomicsDB; 71943; -. [Q8N4M1-1]
DR ProteomicsDB; 71944; -. [Q8N4M1-2]
DR ProteomicsDB; 71945; -. [Q8N4M1-3]
DR Antibodypedia; 33668; 58 antibodies from 15 providers.
DR DNASU; 126969; -.
DR Ensembl; ENST00000271227.11; ENSP00000271227.6; ENSG00000143036.17. [Q8N4M1-1]
DR Ensembl; ENST00000446120.6; ENSP00000389143.2; ENSG00000143036.17. [Q8N4M1-3]
DR Ensembl; ENST00000467909.5; ENSP00000432789.1; ENSG00000143036.17. [Q8N4M1-2]
DR Ensembl; ENST00000527077.5; ENSP00000433641.1; ENSG00000143036.17. [Q8N4M1-4]
DR Ensembl; ENST00000529450.5; ENSP00000431836.1; ENSG00000143036.17. [Q8N4M1-6]
DR GeneID; 126969; -.
DR KEGG; hsa:126969; -.
DR MANE-Select; ENST00000271227.11; ENSP00000271227.6; NM_001114106.3; NP_001107578.1.
DR UCSC; uc001dqv.6; human. [Q8N4M1-1]
DR CTD; 126969; -.
DR DisGeNET; 126969; -.
DR GeneCards; SLC44A3; -.
DR HGNC; HGNC:28689; SLC44A3.
DR HPA; ENSG00000143036; Low tissue specificity.
DR neXtProt; NX_Q8N4M1; -.
DR OpenTargets; ENSG00000143036; -.
DR PharmGKB; PA142670900; -.
DR VEuPathDB; HostDB:ENSG00000143036; -.
DR eggNOG; KOG1362; Eukaryota.
DR GeneTree; ENSGT00940000160336; -.
DR InParanoid; Q8N4M1; -.
DR OMA; QCLGAEY; -.
DR OrthoDB; 329225at2759; -.
DR PhylomeDB; Q8N4M1; -.
DR TreeFam; TF313325; -.
DR PathwayCommons; Q8N4M1; -.
DR Reactome; R-HSA-1483191; Synthesis of PC.
DR Reactome; R-HSA-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR SignaLink; Q8N4M1; -.
DR BioGRID-ORCS; 126969; 17 hits in 1068 CRISPR screens.
DR ChiTaRS; SLC44A3; human.
DR GenomeRNAi; 126969; -.
DR Pharos; Q8N4M1; Tbio.
DR PRO; PR:Q8N4M1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N4M1; protein.
DR Bgee; ENSG00000143036; Expressed in mucosa of transverse colon and 141 other tissues.
DR ExpressionAtlas; Q8N4M1; baseline and differential.
DR Genevisible; Q8N4M1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0015220; F:choline transmembrane transporter activity; TAS:Reactome.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; TAS:Reactome.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..653
FT /note="Choline transporter-like protein 3"
FT /id="PRO_0000191720"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 534..554
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 563..583
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 632..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 412
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 503
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 521
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..48
FT /note="Missing (in isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_036151"
FT VAR_SEQ 11..46
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036152"
FT VAR_SEQ 107..138
FT /note="Missing (in isoform 4, isoform 5 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044713"
FT VAR_SEQ 465
FT /note="Missing (in isoform 5 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045974"
FT VARIANT 438
FT /note="V -> I (in dbSNP:rs859098)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_023405"
FT VARIANT 441
FT /note="G -> W (found in a renal cell carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:21248752"
FT /id="VAR_064752"
FT CONFLICT 3
FT /note="C -> R (in Ref. 1; BAG62846)"
FT /evidence="ECO:0000305"
FT CONFLICT 316
FT /note="F -> L (in Ref. 1; BAG62846)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 653 AA; 73783 MW; 083859F3FC332382 CRC64;
MHCLGAEYLV SAEGAPRQRE WRPQIYRKCT DTAWLFLFFL FWTGLVFIMG YSVVAGAAGR
LLFGYDSFGN MCGKKNSPVE GAPLSGQDMT LKKHVFFMNS CNLEVKGTQL NRMALCVSNC
PEEQLDSLEE VQFFANTSGS FLCVYSLNSF NYTHSPKADS LCPRLPVPPS KSFPLFNRCV
PQTPECYSLF ASVLINDVDT LHRILSGIMS GRDTILGLCI LALALSLAMM FTFRFITTLL
VHIFISLVIL GLLFVCGVLW WLYYDYTNDL SIELDTEREN MKCVLGFAIV STGITAVLLV
LIFVLRKRIK LTVELFQITN KAISSAPFLL FQPLWTFAIL IFFWVLWVAV LLSLGTAGAA
QVMEGGQVEY KPLSGIRYMW SYHLIGLIWT SEFILACQQM TIAGAVVTCY FNRSKNDPPD
HPILSSLSIL FFYHQGTVVK GSFLISVVRI PRIIVMYMQN ALKEQQHGAL SRYLFRCCYC
CFWCLDKYLL HLNQNAYTTT AINGTDFCTS AKDAFKILSK NSSHFTSINC FGDFIIFLGK
VLVVCFTVFG GLMAFNYNRA FQVWAVPLLL VAFFAYLVAH SFLSVFETVL DALFLCFAVD
LETNDGSSEK PYFMDQEFLS FVKRSNKLNN ARAQQDKHSL RNEEGTELQA IVR
