CTL3_MOUSE
ID CTL3_MOUSE Reviewed; 656 AA.
AC Q921V7; G5E8A3;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 3.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Choline transporter-like protein 3;
DE AltName: Full=Solute carrier family 44 member 3;
GN Name=Slc44a3; Synonyms=Ctl3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
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DR EMBL; AC105336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC115727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466532; EDL12341.1; -; Genomic_DNA.
DR EMBL; BC010552; AAH10552.1; -; mRNA.
DR EMBL; BC025548; AAH25548.1; -; mRNA.
DR CCDS; CCDS51060.1; -.
DR RefSeq; NP_663369.2; NM_145394.3.
DR AlphaFoldDB; Q921V7; -.
DR BioGRID; 229459; 1.
DR STRING; 10090.ENSMUSP00000040210; -.
DR GlyGen; Q921V7; 5 sites.
DR PhosphoSitePlus; Q921V7; -.
DR MaxQB; Q921V7; -.
DR PaxDb; Q921V7; -.
DR PeptideAtlas; Q921V7; -.
DR PRIDE; Q921V7; -.
DR ProteomicsDB; 285220; -.
DR Antibodypedia; 33668; 58 antibodies from 15 providers.
DR DNASU; 213603; -.
DR Ensembl; ENSMUST00000039197; ENSMUSP00000040210; ENSMUSG00000039865.
DR GeneID; 213603; -.
DR KEGG; mmu:213603; -.
DR UCSC; uc008rdz.2; mouse.
DR CTD; 126969; -.
DR MGI; MGI:2384860; Slc44a3.
DR VEuPathDB; HostDB:ENSMUSG00000039865; -.
DR eggNOG; KOG1362; Eukaryota.
DR GeneTree; ENSGT00940000160336; -.
DR HOGENOM; CLU_017181_2_0_1; -.
DR InParanoid; Q921V7; -.
DR OMA; QCLGAEY; -.
DR OrthoDB; 329225at2759; -.
DR PhylomeDB; Q921V7; -.
DR TreeFam; TF313325; -.
DR Reactome; R-MMU-1483191; Synthesis of PC.
DR Reactome; R-MMU-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR BioGRID-ORCS; 213603; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Slc44a3; mouse.
DR PRO; PR:Q921V7; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q921V7; protein.
DR Bgee; ENSMUSG00000039865; Expressed in dorsal pancreas and 119 other tissues.
DR Genevisible; Q921V7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015101; F:organic cation transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071705; P:nitrogen compound transport; IEA:UniProt.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..656
FT /note="Choline transporter-like protein 3"
FT /id="PRO_0000191721"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 537..557
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 566..586
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 634..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 506
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 524
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 559
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 656 AA; 73414 MW; D14D4EF81C8510D7 CRC64;
MPGTMQCLGA EYLVSAEKTR QREWRPQIYR KCTDTPWLVL FFLFWTGLVF IMGYSVVAGA
AGRLLFGYDS FGNVCGKKNS PVEGAPLSGQ DMTLKKHVFF MNACNLEVKD RGLGPTALCV
SSCPEKQLDT LEEVQLFANI NGSFLCVYSL NSFNYTQSSS ADTLCPRLPV PPSKPFPLFN
RCIPQTPECY SLFASVLIND ADALHRILSG IMAGRDTILG LCVFTFALSL AMLFAFRFIS
TLLIHIIISL VILGLLFVCG VLWWLYYDYT NDLSTELDTE KENMNCMLAF AIISTVVTVL
LLALIFTLRK RIKLTVELLH VTNKAISSCP FLLFQPLWTC AILIFFWVLW VAVLLSLGTA
GTAQVMEGGQ VEYKPLSGIR YMWWYHLIGL IWTSEFILAC QRMTVAGAMV ACYFNRNQND
PPARPILSSL FVLFCYHQGT AVKGSFLLTV TRIPRVIFMC IYSTLKEPQR SAWSRGEFRC
SHCGLWCLLK YLYHLNQDAY TATAINGTDF CTSAKDAHTI IAKNSSHLTS VNCFGNFVIF
LGKVLVVCFS IFGGLMAFNY SRALQVWAIP LLLVAFFACV VAHSFLSVFE TALDILFLCF
AVDLETNDGS SEKPYFMDPG FLSVIKRTNN LNNAKSQGQK DALPNEEGTE LQPIVR
