ID   CTL3_RAT                Reviewed;         604 AA.
AC   Q6AY92;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Choline transporter-like protein 3;
DE   AltName: Full=Solute carrier family 44 member 3;
GN   Name=Slc44a3; Synonyms=Ctl3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   TISSUE SPECIFICITY.
RC   STRAIN=Wistar; TISSUE=Brain;
RX   PubMed=15715662; DOI=10.1111/j.1471-4159.2004.02962.x;
RA   Traiffort E., Ruat M., O'Regan S., Meunier F.-M.;
RT   "Molecular characterization of the family of choline transporter-like
RT   proteins and their splice variants.";
RL   J. Neurochem. 92:1116-1125(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in colon, kidney and ileum.
CC       {ECO:0000269|PubMed:15715662}.
CC   -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC       {ECO:0000305}.
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DR   EMBL; BC079142; AAH79142.1; -; mRNA.
DR   RefSeq; NP_001013936.1; NM_001013914.1.
DR   AlphaFoldDB; Q6AY92; -.
DR   SMR; Q6AY92; -.
DR   STRING; 10116.ENSRNOP00000052570; -.
DR   GlyGen; Q6AY92; 4 sites.
DR   iPTMnet; Q6AY92; -.
DR   PhosphoSitePlus; Q6AY92; -.
DR   PaxDb; Q6AY92; -.
DR   GeneID; 295417; -.
DR   KEGG; rno:295417; -.
DR   UCSC; RGD:1305808; rat.
DR   CTD; 126969; -.
DR   RGD; 1305808; Slc44a3.
DR   eggNOG; KOG1362; Eukaryota.
DR   InParanoid; Q6AY92; -.
DR   OrthoDB; 329225at2759; -.
DR   PhylomeDB; Q6AY92; -.
DR   Reactome; R-RNO-1483191; Synthesis of PC.
DR   Reactome; R-RNO-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR   PRO; PR:Q6AY92; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0015101; F:organic cation transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0071705; P:nitrogen compound transport; IEA:UniProt.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR007603; Choline_transptr-like.
DR   PANTHER; PTHR12385; PTHR12385; 1.
DR   Pfam; PF04515; Choline_transpo; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..604
FT                   /note="Choline transporter-like protein 3"
FT                   /id="PRO_0000191722"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        485..505
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        514..534
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          581..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        454
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        472
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   604 AA;  67679 MW;  BA47C3A411CE3E1B CRC64;
     MGYSVVAGAA GRLLFGYDSF GNVCGKRNSP VEGAPLSGQD MTLKKHVFFM NACNLEVKDR
     GRGPMALCVS SCPEKQLDTL EEVQLFANIN GSFLCVYSLN SFNYTQSPSA DRLCPRLPVP
     PSKPFPLFNR CIPQTPECYS LFASVLLNDA DALHRILSGI MAGRDTILGL CAFVFALSLA
     MLFTFRFIST LLVHIIISLV ILGLLFVCGV FWWLYYDYTN DLSTELDTEK ENMKCMLAFA
     VITTVVTVVL LALIFTLRKR VKLTVELLRV TNKAISRCPF LLLQPLWTFA ILVFFWVLWV
     AVLLSLGTAG TAQVMEGGQV EYKPLSGIRY LWWYHLIGLI WTSEFILTCQ RMTVAGAMVT
     CYFNRNQNDP PARPILSSLS TLFCYHQGTA VKGSLLLTVT RIPRVIFMYI YSTVKERHSA
     WPRGEFRCSY CGLWCLTNYP YHLNQDAYAA AAINGTDFCT SAKDAHTIIS KNSSHLTSVN
     CFGNFIIFLG KVLVVCFSVF GGLMAFNYNR ALQVWAIPLL LVAFFAYLAA HSFLSVFETV
     LDTLFLCFAV DLETNDGSSE KPYFMDPGFL SFVKRTDHFN NARSQGHKNS LPNEEGTELR
     PIVR