CTL5_HUMAN
ID CTL5_HUMAN Reviewed; 719 AA.
AC Q8NCS7; A0A0A0MRP1; B5MCU3; Q4G0K0; Q8NA44; Q8NB86;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 12-SEP-2018, sequence version 5.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Choline transporter-like protein 5;
DE AltName: Full=Solute carrier family 44 member 5;
GN Name=SLC44A5; Synonyms=CTL5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 307-719 (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION, AND NOMENCLATURE.
RX PubMed=15715662; DOI=10.1111/j.1471-4159.2004.02962.x;
RA Traiffort E., Ruat M., O'Regan S., Meunier F.-M.;
RT "Molecular characterization of the family of choline transporter-like
RT proteins and their splice variants.";
RL J. Neurochem. 92:1116-1125(2005).
CC -!- INTERACTION:
CC Q8NCS7; P23560-2: BDNF; NbExp=3; IntAct=EBI-21504521, EBI-12275524;
CC Q8NCS7; P45973: CBX5; NbExp=3; IntAct=EBI-21504521, EBI-78219;
CC Q8NCS7; P42858: HTT; NbExp=3; IntAct=EBI-21504521, EBI-466029;
CC Q8NCS7; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-21504521, EBI-1055254;
CC Q8NCS7; P16284: PECAM1; NbExp=3; IntAct=EBI-21504521, EBI-716404;
CC Q8NCS7; P54725: RAD23A; NbExp=3; IntAct=EBI-21504521, EBI-746453;
CC Q8NCS7; P50454: SERPINH1; NbExp=3; IntAct=EBI-21504521, EBI-350723;
CC Q8NCS7; Q13148: TARDBP; NbExp=6; IntAct=EBI-21504521, EBI-372899;
CC Q8NCS7; P37173: TGFBR2; NbExp=3; IntAct=EBI-21504521, EBI-296151;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=A;
CC IsoId=Q8NCS7-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=Q8NCS7-4; Sequence=VSP_059803;
CC Name=3;
CC IsoId=Q8NCS7-5; Sequence=VSP_059802, VSP_059803;
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC03655.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK091400; BAC03655.1; ALT_INIT; mRNA.
DR EMBL; AK093170; BAC04084.1; -; mRNA.
DR EMBL; AC118550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC118990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL096829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC876880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471059; EAX06402.1; -; Genomic_DNA.
DR EMBL; BC028743; AAH28743.1; -; mRNA.
DR EMBL; BC034580; AAH34580.1; -; mRNA.
DR EMBL; BC051740; AAH51740.1; -; mRNA.
DR CCDS; CCDS44164.1; -. [Q8NCS7-4]
DR CCDS; CCDS667.1; -. [Q8NCS7-1]
DR RefSeq; NP_001123530.1; NM_001130058.1. [Q8NCS7-4]
DR RefSeq; NP_001307212.1; NM_001320283.1.
DR RefSeq; NP_001307214.1; NM_001320285.1. [Q8NCS7-5]
DR RefSeq; NP_001307216.1; NM_001320287.1. [Q8NCS7-5]
DR RefSeq; NP_689910.2; NM_152697.4. [Q8NCS7-1]
DR RefSeq; XP_016856098.1; XM_017000609.1. [Q8NCS7-1]
DR RefSeq; XP_016856099.1; XM_017000610.1. [Q8NCS7-1]
DR RefSeq; XP_016856100.1; XM_017000611.1. [Q8NCS7-1]
DR AlphaFoldDB; Q8NCS7; -.
DR BioGRID; 128491; 20.
DR IntAct; Q8NCS7; 17.
DR STRING; 9606.ENSP00000359892; -.
DR TCDB; 2.A.92.1.5; the choline transporter-like (ctl) family.
DR GlyGen; Q8NCS7; 3 sites.
DR iPTMnet; Q8NCS7; -.
DR PhosphoSitePlus; Q8NCS7; -.
DR BioMuta; SLC44A5; -.
DR DMDM; 519668678; -.
DR MassIVE; Q8NCS7; -.
DR PaxDb; Q8NCS7; -.
DR PeptideAtlas; Q8NCS7; -.
DR PRIDE; Q8NCS7; -.
DR ProteomicsDB; 72936; -. [Q8NCS7-1]
DR Antibodypedia; 66042; 10 antibodies from 6 providers.
DR DNASU; 204962; -.
DR Ensembl; ENST00000370855.5; ENSP00000359892.5; ENSG00000137968.17. [Q8NCS7-1]
DR Ensembl; ENST00000370859.8; ENSP00000359896.3; ENSG00000137968.17. [Q8NCS7-4]
DR GeneID; 204962; -.
DR KEGG; hsa:204962; -.
DR MANE-Select; ENST00000370859.8; ENSP00000359896.3; NM_001130058.2; NP_001123530.1. [Q8NCS7-4]
DR UCSC; uc001dgt.3; human. [Q8NCS7-1]
DR UCSC; uc001dgu.4; human.
DR CTD; 204962; -.
DR DisGeNET; 204962; -.
DR GeneCards; SLC44A5; -.
DR HGNC; HGNC:28524; SLC44A5.
DR HPA; ENSG00000137968; Tissue enhanced (skin).
DR neXtProt; NX_Q8NCS7; -.
DR OpenTargets; ENSG00000137968; -.
DR PharmGKB; PA142670901; -.
DR VEuPathDB; HostDB:ENSG00000137968; -.
DR eggNOG; KOG1362; Eukaryota.
DR GeneTree; ENSGT00940000156600; -.
DR HOGENOM; CLU_017181_3_1_1; -.
DR InParanoid; Q8NCS7; -.
DR OMA; QCKHENK; -.
DR OrthoDB; 329225at2759; -.
DR TreeFam; TF313325; -.
DR PathwayCommons; Q8NCS7; -.
DR Reactome; R-HSA-1483191; Synthesis of PC.
DR Reactome; R-HSA-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR SignaLink; Q8NCS7; -.
DR BioGRID-ORCS; 204962; 12 hits in 1078 CRISPR screens.
DR ChiTaRS; SLC44A5; human.
DR GenomeRNAi; 204962; -.
DR Pharos; Q8NCS7; Tdark.
DR PRO; PR:Q8NCS7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NCS7; protein.
DR Bgee; ENSG00000137968; Expressed in cortical plate and 134 other tissues.
DR Genevisible; Q8NCS7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0015220; F:choline transmembrane transporter activity; TAS:Reactome.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; TAS:Reactome.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..719
FT /note="Choline transporter-like protein 5"
FT /id="PRO_0000191726"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..242
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..325
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..374
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..460
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 482..515
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 537..610
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 611..631
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 632..649
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 650..670
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 671..719
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 314
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..42
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_059802"
FT VAR_SEQ 683..719
FT /note="CEDLERNDGSTEKPYFVTPNLHGILIKKQLVPQKQKE -> LEDLERNDGST
FT ARPYYVSQPLLKIFQEENPQTRKQ (in isoform 2 and isoform 3)"
FT /id="VSP_059803"
FT CONFLICT 501
FT /note="L -> P (in Ref. 1; BAC04084)"
FT /evidence="ECO:0000305"
FT CONFLICT 647
FT /note="N -> Y (in Ref. 4; AAH28743)"
FT /evidence="ECO:0000305"
FT CONFLICT 688
FT /note="R -> I (in Ref. 1; BAC03655)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 719 AA; 81694 MW; FF5B57849397F031 CRC64;
MNDTEKPADT PSEEEDFGDP RTYDPDFKGP VANRSCTDVL CCMIFLLCII GYIVLGLVAW
VHGDPRRAAY PTDSQGHFCG QKGTPNENKT ILFYFNLLRC TSPSVLLNLQ CPTTQICVSK
CPEKFLTYVE MQLLYTKDKS YWEDYRQFCK TTAKPVKSLT QLLLDDDCPT AIFPSKPFLQ
RCFPDFSTKN GTLTIGSKMM FQDGNGGTRS VVELGIAANG INKLLDAKSL GLKVFEDYAR
TWYWILIGLT IAMVLSWIFL ILLRFIAGCL FWVFMIGVIG IIGYGIWHCY QQYTNLQERP
SSVLTIYDIG IQTNISMYFE LQQTWFTFMI ILCIIEVIVI LMLIFLRNRI RVAIILLKEG
SKAIGYVPST LVYPALTFIL LSICICYWVV TAVFLATSGV PVYKVIAPGG HCIHENQTCD
PEIFNTTEIA KACPGALCNF AFYGGKSLYH QYIPTFHVYN LFVFLWLINF VIALGQCALA
GAFATYYWAM KKPDDIPRYP LFTAFGRAIR YHTGSLAFGS LIIALIQMFK IVLEYLDHRL
KRTQNTLSKF LQCCLRCCFW CLENAIKFLN RNAYIMIAIY GRNFCRSAKD AFNLLMRNVL
KVAVTDEVTY FVLFLGKLLV AGSIGVLAFL FFTQRLPVIA QGPASLNYYW VPLLTVIFGS
YLIAHGFFSV YAMCVETIFI CFCEDLERND GSTEKPYFVT PNLHGILIKK QLVPQKQKE
