CTL5_MACFA
ID CTL5_MACFA Reviewed; 717 AA.
AC Q95JW2; Q95JX5;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Choline transporter-like protein 5;
DE AltName: Full=Solute carrier family 44 member 5;
GN Name=SLC44A5; Synonyms=CTL5; ORFNames=QtsA-10162, QtsA-12677;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB62997.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB070066; BAB63011.1; -; mRNA.
DR EMBL; AB070052; BAB62997.1; ALT_INIT; mRNA.
DR RefSeq; NP_001274644.1; NM_001287715.1.
DR AlphaFoldDB; Q95JW2; -.
DR SMR; Q95JW2; -.
DR STRING; 9541.XP_005543051.1; -.
DR Ensembl; ENSMFAT00000012221; ENSMFAP00000037969; ENSMFAG00000038111.
DR GeneID; 102128358; -.
DR CTD; 204962; -.
DR VEuPathDB; HostDB:ENSMFAG00000038111; -.
DR eggNOG; KOG1362; Eukaryota.
DR GeneTree; ENSGT00940000156600; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000038111; Expressed in temporal lobe and 9 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015220; F:choline transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:UniProt.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..717
FT /note="Choline transporter-like protein 5"
FT /id="PRO_0000191727"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..242
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..325
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..374
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..460
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 482..515
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 537..610
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 611..631
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 632..649
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 650..670
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 671..717
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 314
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 287
FT /note="W -> R (in Ref. 1; BAB62997)"
FT /evidence="ECO:0000305"
FT CONFLICT 583
FT /note="N -> S (in Ref. 1; BAB62997)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 717 AA; 81580 MW; 47C4C77C9E41A24B CRC64;
MNDTEKPADT ASEEEDFGDP RTYDPDFKGP VSNRSCTDVL CCMIFLLCIV GYIVLGLVAW
VHGDPRRAAY PTDSQGHFCG QKGTPNENKT ILFYFNLLRC TSPSVLLNLQ CPTTQICVSK
CPEKFLTYVE MQLLYTKDKS HWEDYRQFCK TTAKPVKSLT QLLLDDDCPT AIFPSKPFLQ
RCFPDFSTKN GTLTIGSQIV FQDGNGGTRS VIELRDAANG INKLLDAKSL GLKVFEDYAT
TWYWILIGLM IAMVLSWIFL ILLRFIAGCL FWVFMIGVIG IIGYGIWHCY QQYTNLQEHP
RSVLTVYDIG IQTNISMYFE LQQTWFTLMI ILCIIEVIVI LMLIFLRNRI RVAIILLKEG
SKAIGYVPST LVYPALTFIL LSICICYWVV TAVFLATSGV PVYKVIAPEG HCIHENQTCD
PEIFNTTEIA KACPGALCNF AFYGGKSLYH QYIPTFHVYN LFVFLWLINF VIALGQCALA
GAFATYYWAM KKPDDIPRYP LFTAFGRAIR YHTGSLAFGS LIIALIQMFK IVLEYLNHRL
KRTENTLSKF LQCCLRCCFW CLENAIKFLN RNAYIMIAIY GRNFCRSAKD AFNLLMRNVL
KVAVTDEVTY FVLFLGKILV AGSIGVLAFL FFTQRLPVIA QGPASLNYYW VPLLTVILGS
YLIAHGFFSV YAMCVETIFI CFLEDLERND GSTARPYYVS QPLLKIFQEE NLQTKQQ
