CTL5_MOUSE
ID CTL5_MOUSE Reviewed; 710 AA.
AC Q5RJI2;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Choline transporter-like protein 5;
DE AltName: Full=Solute carrier family 44 member 5;
GN Name=Slc44a5; Synonyms=Ctl5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
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DR EMBL; BC086641; AAH86641.1; -; mRNA.
DR CCDS; CCDS38679.1; -.
DR RefSeq; NP_001074732.1; NM_001081263.1.
DR AlphaFoldDB; Q5RJI2; -.
DR BioGRID; 232387; 1.
DR STRING; 10090.ENSMUSP00000087394; -.
DR GlyGen; Q5RJI2; 2 sites.
DR PhosphoSitePlus; Q5RJI2; -.
DR jPOST; Q5RJI2; -.
DR PaxDb; Q5RJI2; -.
DR PeptideAtlas; Q5RJI2; -.
DR PRIDE; Q5RJI2; -.
DR ProteomicsDB; 285396; -.
DR Antibodypedia; 66042; 10 antibodies from 6 providers.
DR DNASU; 242259; -.
DR Ensembl; ENSMUST00000089948; ENSMUSP00000087394; ENSMUSG00000028360.
DR GeneID; 242259; -.
DR KEGG; mmu:242259; -.
DR UCSC; uc008ruk.1; mouse.
DR CTD; 204962; -.
DR MGI; MGI:3035141; Slc44a5.
DR VEuPathDB; HostDB:ENSMUSG00000028360; -.
DR eggNOG; KOG1362; Eukaryota.
DR GeneTree; ENSGT00940000156600; -.
DR HOGENOM; CLU_017181_3_1_1; -.
DR InParanoid; Q5RJI2; -.
DR OMA; FATYYWT; -.
DR OrthoDB; 329225at2759; -.
DR PhylomeDB; Q5RJI2; -.
DR TreeFam; TF313325; -.
DR Reactome; R-MMU-1483191; Synthesis of PC.
DR Reactome; R-MMU-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR BioGRID-ORCS; 242259; 1 hit in 76 CRISPR screens.
DR ChiTaRS; Slc44a5; mouse.
DR PRO; PR:Q5RJI2; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q5RJI2; protein.
DR Bgee; ENSMUSG00000028360; Expressed in cortical plate and 55 other tissues.
DR ExpressionAtlas; Q5RJI2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015101; F:organic cation transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071705; P:nitrogen compound transport; IEA:UniProt.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..710
FT /note="Choline transporter-like protein 5"
FT /id="PRO_0000191728"
FT TOPO_DOM 1..32
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..236
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..319
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 341..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 367..368
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 390..454
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 476..509
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 531..604
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 605..625
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 626..643
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 644..664
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 665..710
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 710 AA; 81429 MW; E569C95E5CB7990C CRC64;
MARKRKPPSS QGDPRRYDPD FQGPTAKRTC TDVLCCLIFL LFILGYVLLG LLAWAHGDPR
KMAYPTDSQG HFCGQKGTPN ENKTVLFYFN IFRCTSPSMM LRLQCSTTQI CVSRCPERFL
TYLDMQFLNK EDKNYWEYYR QFCKAKAKPV ETLRDLLISG DCPLAVYPSR PFLQRCIPDL
SALNGTWTPG SRMKFEDGSG QTRTMLEFRE AANGISDLIN ARTIGLKLLE DYATSWKWIL
IGLTVAMALS WTFLILLRFT AGFLFWFFIF GVLGIIGYGI WYCFLEYSSI QQRPQSTFWM
YGFGIQRRVN MFFHLKETWF SMMIILSAIE IIIIIVLIFL RTRIQVAIIL LQEGSKAISY
LPSALIYPVL TFILLSICIS YWAVTAVFLA TSGVPIFKVM VPAGQCIYED ETCDPEIFPY
TNIPKDCPGA SCNFAFYGGR SMYHNYILTF QVYNLFAFLW LINFVIALGQ CALAGAFASY
YWAMKKPDDI PPYPLFTAFG RAVRYHTGSL AFGSLILASV QMFKVIVEYL DRRLKKAQNS
AAQFLHCCLQ CCFWCLEKMV KFLNRNAYIM IALYGKNFCE STRDAFYLLM RNILKVTVTD
EVTYFVLLLG KVLVSGIVGV LAFLLFTERL QIIVDGPTTL NYYWVPFLTL VFGSYMIAHG
FFSVYSMCVE TIFICFLEDL ERNEGSPSRP YFVTPALMNI LLEQGKIKKQ
