ID   CTL5_XENTR              Reviewed;         714 AA.
AC   B0JZD0;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Choline transporter-like protein 5;
DE   AltName: Full=Solute carrier family 44 member 5;
GN   Name=slc44a5; Synonyms=ctl5;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC       {ECO:0000305}.
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DR   EMBL; BC159131; AAI59132.1; -; mRNA.
DR   RefSeq; NP_001120142.1; NM_001126670.1.
DR   AlphaFoldDB; B0JZD0; -.
DR   GeneID; 100145179; -.
DR   KEGG; xtr:100145179; -.
DR   CTD; 204962; -.
DR   Xenbase; XB-GENE-987953; slc44a5.
DR   InParanoid; B0JZD0; -.
DR   OrthoDB; 329225at2759; -.
DR   Reactome; R-XTR-1483191; Synthesis of PC.
DR   Reactome; R-XTR-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR007603; Choline_transptr-like.
DR   PANTHER; PTHR12385; PTHR12385; 1.
DR   Pfam; PF04515; Choline_transpo; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..714
FT                   /note="Choline transporter-like protein 5"
FT                   /id="PRO_0000359726"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..237
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..261
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        283..320
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        342..346
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        368..369
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        391..455
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        456..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        477..510
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        511..531
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        532..605
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        606..626
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        627..644
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        645..665
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        666..711
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        132
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        192
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        205
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   714 AA;  81265 MW;  22BBAF7DB25DE9F5 CRC64;
     MGRRSAAPTS PFGEPRKFDP KFKGPIGKRH CTDVLCCIIF VVVILGYIAL GVVAWIHGDP
     RKIIYPTDSY GQFCGQKGTP NENKTILMYF NILRCASPVV LINLQCPTTQ LCVSKCPDRF
     ATYLDMQANR FNNSYWEYYK QFCKPGFDKP RKSITEVLRD EDCPSMIIPS RPFLQRCFPD
     FSTRNGVLTV ANKTEFKDGI GQMRNVTDLR SAANGINNVL DARSVGMKIF EDYASSWYWI
     LIALFIAMVV SLLFLILLRF TAGVFFWIFI IGVIGVVGYG IWHCFWEYDS LKGVPGADLT
     IYDIGLQTDF RVYLQLRQTW LAFMILLCIV EVIIILMLIF LRNRIRIAIA LLQEGSRAIG
     YIMSTLFYPI ITFILIAICI SYWAVTAVFM ATSGEPIYKV MANKTLCKYA DITCIPETFN
     TTNVTRLCPG AQCTFAFYGG ESFYHQYILI FQLCNVFVFL WLVNFSIALG QCTLAGAFAS
     YYWAFKKPAD IPACPLFSSF GRAIRYHTGS LALGSLILAL VQFIRIILEY LDHKLKASQN
     SFAKFILCCL KCCFWCLEKF IKFMNRNAYI MIAIYGKNFC TSAKDAFFLL MRNVIRVAVL
     DKVTDFLLFL GKVFVTGSVG VLAFFFFTRK IPVLTDEAPA LNYYWVPLLT VLIGSYLIAH
     GFFSVYAMCV DTLFLCFCED LERNNGSSSK PYYMSPNLHR ILGKKEILSK KAKR