CTLHA_DICDI
ID CTLHA_DICDI Reviewed; 548 AA.
AC Q54IJ2;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=CTL-like protein DDB_G0288717;
GN ORFNames=DDB_G0288717;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000120; EAL63090.1; -; Genomic_DNA.
DR RefSeq; XP_636594.1; XM_631502.1.
DR AlphaFoldDB; Q54IJ2; -.
DR TCDB; 2.A.92.1.9; the choline transporter-like (ctl) family.
DR PaxDb; Q54IJ2; -.
DR EnsemblProtists; EAL63090; EAL63090; DDB_G0288717.
DR GeneID; 8626768; -.
DR KEGG; ddi:DDB_G0288717; -.
DR dictyBase; DDB_G0288717; -.
DR eggNOG; KOG1362; Eukaryota.
DR HOGENOM; CLU_017181_2_1_1; -.
DR InParanoid; Q54IJ2; -.
DR OMA; IETVYVC; -.
DR PhylomeDB; Q54IJ2; -.
DR Reactome; R-DDI-1483191; Synthesis of PC.
DR Reactome; R-DDI-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR Reactome; R-DDI-6798163; Choline catabolism.
DR PRO; PR:Q54IJ2; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007603; Choline_transptr-like.
DR PANTHER; PTHR12385; PTHR12385; 1.
DR Pfam; PF04515; Choline_transpo; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..548
FT /note="CTL-like protein DDB_G0288717"
FT /id="PRO_0000359735"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 479..499
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 273
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 377
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 544
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 548 AA; 60257 MW; 8E1319CD3A98DD43 CRC64;
MWAPEEDYKQ PLLTNSRVAN NGNNNNSNGR GGSSSPSTRL QPEHSSRKCN DILFTILFLL
VIGGMAAISG IAYTKGDPSR LVPNAPNIPS IPGFNTNTTS SENPIEQYFV SHLESLVAEL
KRDKDILIYS VLLAIALGAA WIQLLKSFTR FFIYFTLCVG VALVATLGGL FMALGHKEGS
ESTMIVGGCI IICTLVLVVV IVYLRKSIDL TCAMFTETCR GVQRSPSVFV IASLVVLFFI
GFIAYWTSSF IYLFSIPGST VNPLNDHTSS EANSTDSEQE QSAFNTKIRN LMYFMIFGFF
WASSFISAVF QHCVAGVVSN WYFSRDPTGK SLVGQENAYR SLGRALSTSF GSLAFGSLLI
AFIEFMAFML RVCKNSNATN KLVVMVVSCL QCILGCIESI VRWINKFGYI YVAMHGHSFC
TSTKECFDLI SRNMFNAVIM DFIGGLVLLL GKILGSAASA LFTTALLYGM GKSLNPITIA
LSAIFAFCIF NLFTHIVGIG TDTIFVCYLE DLETNKDGNL YISPDLHELL QDKCNECKEK
EQKNQSKV
