ID   CTM1_ASHGO              Reviewed;         478 AA.
AC   Q756K8;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Cytochrome c lysine N-methyltransferase 1;
DE            EC=2.1.1.59;
GN   Name=CTM1; OrderedLocusNames=AER246W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Methyltransferase which mediates trimethylation of cytochrome
CC       c (CYC1). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:24312, Rhea:RHEA-COMP:9754, Rhea:RHEA-COMP:9755,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.59;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00943};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- DOMAIN: The SET-like region, although related with the SET domain is
CC       not detected by any prediction method. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190,
CC       ECO:0000255|PROSITE-ProRule:PRU00943}.
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DR   EMBL; AE016818; AAS52927.1; -; Genomic_DNA.
DR   RefSeq; NP_985103.1; NM_210457.1.
DR   AlphaFoldDB; Q756K8; -.
DR   STRING; 33169.AAS52927; -.
DR   EnsemblFungi; AAS52927; AAS52927; AGOS_AER246W.
DR   GeneID; 4621313; -.
DR   KEGG; ago:AGOS_AER246W; -.
DR   eggNOG; ENOG502RXKP; Eukaryota.
DR   HOGENOM; CLU_571046_0_0_1; -.
DR   InParanoid; Q756K8; -.
DR   OMA; NEHALMI; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000277; F:[cytochrome c]-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; IBA:GO_Central.
DR   InterPro; IPR025815; Ctm1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS51611; SAM_MT59; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..478
FT                   /note="Cytochrome c lysine N-methyltransferase 1"
FT                   /id="PRO_0000228981"
FT   DOMAIN          32..284
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   REGION          199..299
FT                   /note="SET-like"
SQ   SEQUENCE   478 AA;  53392 MW;  7A392302D95972B5 CRC64;
     MRCGWMAGSS ETVGIMDTAD WYIGHGQVTV APCVSIERSQ IKSPDSGYGV FVDVDKLQEE
     ECEAVELLRV PYGNVISVRT LMDWLSGRGD GYDASKDLIK TYLALFLEDT SNHRFVTETN
     MLILYLALMA ILSERGYGFP DKFVIYLRDV LLQTRLLTPV LEVLTQEAGD AGAHYRNGPQ
     EIFLSTLLQF ISGAFMGCTR AVVLRVYAAV LSRCLEIPHE TSPGSEDYTV SSSLVPILDF
     TNHSCEHRNA YFDVDRESGD VLLMLDVAAC AGLGDRFEVF ISYCPVEELV HFKHTYGFFP
     RASCGTQFWH MFLSDTWLKE ERAPHGSGSL FQIYSELRVL PYIELALISG QVYVNDYCSS
     FPELLLPFVN IEALSDKESK LTALKGDQQL LAEAKTNFLS FLARYLDKLV ANGPIRHSGP
     VCASLRDILL RELELSKRLR NTLQHGSAFL SSHMADTSPP YCPSPAPSPP YAYMYTSS