ID   CTM1_CANGA              Reviewed;         551 AA.
AC   Q6FR37;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Cytochrome c lysine N-methyltransferase 1;
DE            EC=2.1.1.59;
GN   Name=CTM1; OrderedLocusNames=CAGL0I01210g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Methyltransferase which mediates trimethylation of cytochrome
CC       c (CYC1). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:24312, Rhea:RHEA-COMP:9754, Rhea:RHEA-COMP:9755,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.59;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00943};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- DOMAIN: The SET-like region, although related with the SET domain is
CC       not detected by any prediction method. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190,
CC       ECO:0000255|PROSITE-ProRule:PRU00943}.
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DR   EMBL; CR380955; CAG60244.1; -; Genomic_DNA.
DR   RefSeq; XP_447307.1; XM_447307.1.
DR   AlphaFoldDB; Q6FR37; -.
DR   STRING; 5478.XP_447307.1; -.
DR   EnsemblFungi; CAG60244; CAG60244; CAGL0I01210g.
DR   GeneID; 2889115; -.
DR   KEGG; cgr:CAGL0I01210g; -.
DR   CGD; CAL0132300; CAGL0I01210g.
DR   VEuPathDB; FungiDB:CAGL0I01210g; -.
DR   eggNOG; ENOG502RXKP; Eukaryota.
DR   HOGENOM; CLU_026942_0_0_1; -.
DR   InParanoid; Q6FR37; -.
DR   OMA; NEHALMI; -.
DR   Proteomes; UP000002428; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000277; F:[cytochrome c]-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0018022; P:peptidyl-lysine methylation; IEA:InterPro.
DR   InterPro; IPR025815; Ctm1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS51611; SAM_MT59; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..551
FT                   /note="Cytochrome c lysine N-methyltransferase 1"
FT                   /id="PRO_0000228982"
FT   DOMAIN          46..273
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   REGION          184..288
FT                   /note="SET-like"
SQ   SEQUENCE   551 AA;  63533 MW;  639D2E7A75853C0E CRC64;
     MELANICNAT IAKGIAVQKD SYGGYGVYIV DPGALVGCND PKLGGDKIEL LRVSSVFNVK
     NLMEAMNALE GEYAEDGQRA ADMFKSIIGS SIEELSAVSE TCLLVYFMMV IYLMGEQGYA
     VPMKISRYID TVLLGTTVNN ASNCIESMLI HYEHVALFHE LDNNLQKLHK TLISKMPSKK
     NYSIELLRQI YSATVSRVLE IPQELHEENY MDNYVVTPSL VPILDYVNHG DKTSRNAYYD
     VDRRKGDIIL YLDLTVVNPG KLKPNTEVLI TYKDIEDSLA MITKYGFDPA NYTTTGTKIF
     SCTFDKMYLS TNKFDNEIDI RNFYQWFSIN PSLQFVLNSE NEWLINDSLA EFERLLVPFA
     TSSQRNEHYW IYSDGDDARK RFMEYFDIDE VEDEDEAWAQ LETQFKWFES SENDLMPFPP
     CVWTVKSKFL KEKEATGYEL EKVIQNKLEN SRALYNETTN QFQAYLENYL DYRIDVLQEY
     SPEDTENENA VSQLIARELS VLLKIRDRIN NNKSIFLNSE DKKYAKLPLL PTKNVERPPW
     LSEGDDDFDQ D