ID   CTNB_TRIGR              Reviewed;         820 AA.
AC   P35223;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Catenin beta;
DE   AltName: Full=Beta-catenin;
OS   Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Temnopleuroida; Toxopneustidae; Tripneustes.
OX   NCBI_TaxID=7673;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8318544; DOI=10.1016/0167-4781(93)90134-y;
RA   Rosenthal E.T.;
RT   "Identification of homologues to beta-catenin/plakoglobin/armadillo in two
RT   invertebrates, Urechis caupo and Tripneustes gratilla.";
RL   Biochim. Biophys. Acta 1173:337-341(1993).
CC   -!- FUNCTION: Binds to the cytoplasmic domain of the cell-cell adhesion
CC       molecule E-cadherin, and perhaps to other (membrane) proteins. The
CC       association of catenins to cadherins produces a complex which is linked
CC       to the actin filament network, and which seems to be of primary
CC       importance for cadherins cell-adhesion properties.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR   EMBL; L10354; AAA30089.1; -; mRNA.
DR   PIR; S33794; S33794.
DR   AlphaFoldDB; P35223; -.
DR   SMR; P35223; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR013284; Beta-catenin.
DR   PANTHER; PTHR45976; PTHR45976; 1.
DR   Pfam; PF00514; Arm; 3.
DR   PRINTS; PR01869; BCATNINFAMLY.
DR   SMART; SM00185; ARM; 12.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 9.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cytoplasm; Cytoskeleton; Repeat.
FT   CHAIN           1..820
FT                   /note="Catenin beta"
FT                   /id="PRO_0000064274"
FT   REPEAT          157..196
FT                   /note="ARM 1"
FT   REPEAT          199..239
FT                   /note="ARM 2"
FT   REPEAT          241..280
FT                   /note="ARM 3"
FT   REPEAT          283..322
FT                   /note="ARM 4"
FT   REPEAT          367..405
FT                   /note="ARM 5"
FT   REPEAT          406..445
FT                   /note="ARM 6"
FT   REPEAT          448..489
FT                   /note="ARM 7"
FT   REPEAT          495..535
FT                   /note="ARM 8"
FT   REPEAT          603..642
FT                   /note="ARM 9"
FT   REPEAT          644..683
FT                   /note="ARM 10"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          708..811
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   820 AA;  89361 MW;  57255E0F57795FD3 CRC64;
     MEQARYSNQQ SVNPQQKGFG GPGLQDLPKQ DPMQNTMEWQ HHGYGMDSGF QSSATSHPPS
     VSSKSRHEDG GEEAQAQGMF EWDAGYGQAY TQEQVDEMNQ QLTQTRSQRV RAAMFPETLE
     EGVQIPSTQF DPAHPTAVQR LSEPSQMLKH AVVNLINYQD DADLATRAIP ELTKLLNDDD
     LVVVNQAAMM VHQLSKKEAS RHAIMNSPQM VAALVRAMSN SNDAETTRCA AGTLHNLSHH
     RAGLLQIFKS GGIPALIKLL SSPVESVLFY AITTLHNLLL HQEGSKMAVR LAGGLQKMVA
     LLSRNNPKFL AITTDCLQIL AYGNQESKLI ILASGGPAAL VHIMRTYDYE KLLWTTSRVL
     KVLSVCHNNK PAIVEAGGMS ALGLHLGHHS NRLVQNCLWT LRNLSDCHRG TDDIEPLLQM
     LVQLLASNDI NVVTCACGIL SNLTCNNSRN KMIVSQMAGV EALVQTLMKA GDREEITEPA
     VCALRHVTSR HPGAEMGQNT VRLNYGIPVI VKLLHPPSRW PLIKATVGLI RNLALCSANH
     APLREQGALH RLVQLLMRAH QDTQRRSSMG STGSQGGNYA DGVRMEDIVE GTTGALHILA
     RDSHNRALIQ GLNCIPLFVQ LLYNNIENIQ RVAAGVLSEL SLEKQGAEMI EQEGATAPLT
     ELLHSRNEGV ATYAAAVLYR MSDDKPQDYK KRISVELGNS LFRGDSVPWG DPLDMPSDNQ
     ILPPSSMGGH PPDPGYPQPG SVHSLHSNHG EYRQPPPPMQ GYHDGTGPIE PMMQDLDLGG
     GGDFGMDPGL PDMGPPASDL NLDSIPPADN TGLAFFDTDL