ID   CTNB_URECA              Reviewed;         818 AA.
AC   P35224;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Catenin beta;
DE   AltName: Full=Beta-catenin;
OS   Urechis caupo (Innkeeper worm) (Spoonworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC   Echiura; Xenopneusta; Urechidae; Urechis.
OX   NCBI_TaxID=6431;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8318544; DOI=10.1016/0167-4781(93)90134-y;
RA   Rosenthal E.T.;
RT   "Identification of homologues to beta-catenin/plakoglobin/armadillo in two
RT   invertebrates, Urechis caupo and Tripneustes gratilla.";
RL   Biochim. Biophys. Acta 1173:337-341(1993).
CC   -!- FUNCTION: Binds to the cytoplasmic domain of the cell-cell adhesion
CC       molecule E-cadherin, and perhaps to other (membrane) proteins. The
CC       association of catenins to cadherins produces a complex which is linked
CC       to the actin filament network, and which seems to be of primary
CC       importance for cadherins cell-adhesion properties.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR   EMBL; L10355; AAA30330.1; -; mRNA.
DR   PIR; S33793; S33793.
DR   AlphaFoldDB; P35224; -.
DR   SMR; P35224; -.
DR   PRIDE; P35224; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR013284; Beta-catenin.
DR   PANTHER; PTHR45976; PTHR45976; 1.
DR   Pfam; PF00514; Arm; 3.
DR   PRINTS; PR01869; BCATNINFAMLY.
DR   SMART; SM00185; ARM; 12.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 9.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cytoplasm; Cytoskeleton; Repeat.
FT   CHAIN           1..818
FT                   /note="Catenin beta"
FT                   /id="PRO_0000064275"
FT   REPEAT          164..203
FT                   /note="ARM 1"
FT   REPEAT          248..287
FT                   /note="ARM 2"
FT   REPEAT          412..451
FT                   /note="ARM 3"
FT   REPEAT          454..495
FT                   /note="ARM 4"
FT   REPEAT          501..541
FT                   /note="ARM 5"
FT   REPEAT          543..582
FT                   /note="ARM 6"
FT   REPEAT          648..687
FT                   /note="ARM 7"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          48..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          732..818
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        751..773
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        800..818
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   818 AA;  89070 MW;  1DF174BEEF745C1D CRC64;
     METYQQMNSG SGPRSVGTPQ GQYMDVGEMP PMDAKQQTML WQQNQYMGDS GIQSGATTQA
     PPSVSSKHGL DDMDTGEGMD TSRMMFDFDQ GFSTQAFTQE QVDEMNQQLN QTRSQRVRAA
     MFPETLEEGV QIPSTQLDPG QPTAVQRLSE PSQMLKHAVV NLINYQDDAD LATRAIPELT
     KLLNDEDQVV VSQAAMMVHQ LSKKEASRHA IMNSPQMVAA LVRAMTNTND LETTRCAAGT
     LHNLSHHRQG LLTIFKSGGI PALVKLLSSP VESVLFYAIT TLHNLLLHQE GSKMAVRLAG
     GLQKMVLLLQ RNNLKFLAIT TDCLQILAYG NQESKLIILA SGGPGELVRI MRSYTYEKLL
     WTTSRVLKVL SVCASNKPAI VEAGSAGPSM HLGHQSQRLV QNCLWTLRNL SDAATKSSDI
     EGLLQMLVQL LASNDINIVT CAAGILSNLT CNNQRNKVTV CQVGGIEALV RTILQAGDRE
     DITEPAVCAL RHLTSRHGEA EMAQNAVRLH YGLPVLVKLL HPPSRWPLIK AVVGLIRNLA
     LCPANHAPLR EHGAIPRIVQ LLIRAHQDTQ RRATAGSGNT SAYVDGVRME EIVEGTVGAL
     HIMAREAHNR AVIRGLNCIS LFAQLLYSPI DNIQRVAAGV LCELAADKEG AEMIEQEGTT
     APLTELLHSR NEGVATYAAA VLFRMSEDKP QDYKKRLSVE LTSSLFRGEQ VPWGEPPGLD
     DMDSSQLLPE EQGFRGYQGS GPGSVPSGPP HDMNRQDSMQ GLELGSQQGT AYGSHMPDLG
     PNTDLHFDPM DGGGSSMGGP HTPTDPQNQM AAWFDTDL