CTNC_DICDI
ID CTNC_DICDI Reviewed; 222 AA.
AC Q86HV8; Q551J9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Countin-3;
DE Flags: Precursor;
GN Name=ctnC; ORFNames=DDB_G0276479;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX PubMed=12385972; DOI=10.1080/1025814021000014001;
RA Okuwa T., Katayama T., Takano A., Yasukawa H.;
RT "Identification of the homolog of cell-counting factor in the cellular
RT slime mold Dictyostelium discoideum.";
RL J. Biochem. Mol. Biol. Biophys. 6:351-355(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May control the size of the multicellular structure.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the vegetative cells, decreases in
CC the aggregating stage, increases in the mid-developmental stage and
CC decreases again in subsequent stages. {ECO:0000269|PubMed:12385972}.
CC -!- SIMILARITY: Belongs to the countin family. {ECO:0000305}.
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DR EMBL; AB211530; BAD98303.1; -; Genomic_DNA.
DR EMBL; AAFI02000015; EAL69193.1; -; Genomic_DNA.
DR RefSeq; XP_643135.1; XM_638043.1.
DR AlphaFoldDB; Q86HV8; -.
DR PaxDb; Q86HV8; -.
DR EnsemblProtists; EAL69193; EAL69193; DDB_G0276479.
DR GeneID; 8620541; -.
DR KEGG; ddi:DDB_G0276479; -.
DR dictyBase; DDB_G0276479; ctnC.
DR eggNOG; ENOG502S5J5; Eukaryota.
DR HOGENOM; CLU_095805_0_0_1; -.
DR InParanoid; Q86HV8; -.
DR OMA; ICEEWIP; -.
DR PhylomeDB; Q86HV8; -.
DR PRO; PR:Q86HV8; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR008139; SaposinB_dom.
DR SMART; SM00741; SapB; 1.
DR PROSITE; PS50015; SAP_B; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..222
FT /note="Countin-3"
FT /id="PRO_0000327910"
FT DOMAIN 21..105
FT /note="Saposin B-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT CARBOHYD 218
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT DISULFID 25..101
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT DISULFID 28..95
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
FT DISULFID 56..68
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00415"
SQ SEQUENCE 222 AA; 24114 MW; A35CF4987A7A75DA CRC64;
MNKILSLFLI TILLISKVMS SSEECKLCTD FMYDSLNELI EIAINGGVIG SCGALCNKLG
IAPLCMVCAI ACDAVGINGF MDLLQDVFPD PIYICESVKM CQYNDKANAT ITEVVINPMS
GNVGDTFKIG VSFNVTNTIA TGEILWNVVD PRGFQFGETE VIIDAAPSIY GAAFSFQATP
SEQEEFPPGE YQLQMQICEG TCGSPHPHSY ILSNQYLNFT II