ID   CTNC_MONPU              Reviewed;         521 AA.
AC   Q1ERH8;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Citrinin biosynthesis cluster MFS transporter ctnC;
GN   Name=ctnC;
OS   Monascus purpureus (Red mold) (Monascus anka).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Monascus.
OX   NCBI_TaxID=5098;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17586673; DOI=10.1128/aem.01979-06;
RA   Shimizu T., Kinoshita H., Nihira T.;
RT   "Identification and in vivo functional analysis by gene disruption of ctnA,
RT   an activator gene involved in citrinin biosynthesis in Monascus
RT   purpureus.";
RL   Appl. Environ. Microbiol. 73:5097-5103(2007).
CC   -!- FUNCTION: MFS transporter; part of the gene cluster that mediates the
CC       biosynthesis the mycotoxin citrinin, a hepato-nephrotoxic compound to
CC       humans due to inhibition of respiration complex III (PubMed:17586673).
CC       {ECO:0000305|PubMed:17586673}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC       {ECO:0000255}.
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DR   EMBL; AB243687; BAE95340.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q1ERH8; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 2.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..521
FT                   /note="Citrinin biosynthesis cluster MFS transporter ctnC"
FT                   /id="PRO_0000440326"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        489..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        383
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   521 AA;  57721 MW;  06C76DD4B40E9E2F CRC64;
     MKEEIDAPVS TDASGTDLEN ARDQPSGEKP TAVDIYLVEW DGPNDPELPM NFPLWKKSLI
     TCIFSTLTIW VTFSSSVFSA AAGITSKEFH VSVEVMTLGT SLTVLGFTVG PLVWGPMSEL
     YGRLKPLYIG YAIFIIFQVP VAVAQNLETL MLARFFLGFF GTSALAIIPG ALADFWGPVE
     RAIAISLFSA ATFVGPIFGP IMYVNTMITL VNGVWTRANH DMSSGGFIVD SSLGWRWTAW
     ITMIPASFFG IIAFLTLPET YHPVLLQRRA SRLRKETRIW AYHSRLDENT PTFGEILTKY
     LFRPIQMLFL EPILVCMTIY ISLIYGILYL FFVAYPIAFR EVRNWKSLGI AALPFLGILV
     GVLMGCLLVT IATRLWYAPK LQNGSVVPED RLPPMIVAAI LLPIGLFWFG WTSSPSISWA
     PQAIAGAPIG MGILMIWMQG LNYLIDVYLV VANSAMSANT LIRSAVSAAF PLFATAMYHK
     LGVDWATSLL GFLSIAMIPI PVIFYFYGAK IRALSRFSPK W