ID   CTNR_MONRU              Reviewed;         509 AA.
AC   A0A162J452;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   06-JUL-2016, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Citrinin biosynthesis transcriptional activator mrl3 {ECO:0000303|Ref.1};
GN   Name=ctnA {ECO:0000303|PubMed:27998068}; Synonyms=mrl3 {ECO:0000303|Ref.1};
OS   Monascus ruber (Mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Monascus.
OX   NCBI_TaxID=89489;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M7;
RX   DOI=10.1039/C5SC04027B;
RA   He Y., Cox R.J.;
RT   "The molecular steps of citrinin biosynthesis in fungi.";
RL   Chem. Sci. 7:2119-2127(2016).
RN   [2]
RP   INDUCTION.
RC   STRAIN=M7;
RX   PubMed=27998068; DOI=10.1021/acs.jafc.6b04056;
RA   Wang L., Dai Y., Chen W., Shao Y., Chen F.;
RT   "Effects of light intensity and color on the biomass, extracellular red
RT   pigment, and citrinin production of Monascus ruber.";
RL   J. Agric. Food Chem. 64:9506-9514(2016).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of the mycotoxin citrinin,
CC       a hepato-nephrotoxic compound to humans due to inhibition of
CC       respiration complex III (Ref.1). {ECO:0000305|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255}.
CC   -!- INDUCTION: Expression is stimulated under green light conditions
CC       (PubMed:27998068). {ECO:0000269|PubMed:27998068}.
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DR   EMBL; KT781075; ALI92652.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A162J452; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..509
FT                   /note="Citrinin biosynthesis transcriptional activator
FT                   mrl3"
FT                   /id="PRO_0000440325"
FT   DNA_BIND        24..51
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          97..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  57541 MW;  25EDB9D623DE20D7 CRC64;
     MASTAHRQPS RPTTRQRQRT GRACEECRRR KLRCDGQQPR CGVCVDSGVT CEVNSQRRPR
     GPKKGYLTAL RNRVAMLETR LPAQHLVGPL SEFNPLSTPL TNDHHDGCSV SSASSRSDSN
     PPPTVSEPDM SLPNTTTSVS SAPSFATCSK DIGGAEPITE LVQAELNQLY FDRVHPSIQI
     LHQRRYLGWA RNAAKKTSRR CLQYAVWTLA SLLSAQFQHL QDSFYQETKR TLEFSYLSGD
     SNAPVDTEEI QAWILIATYE SMRTFHRSAW MSAGRAFRLV QLMRLHEIDS PTKPPVPEAD
     LVETEEKRRV FWMAYFLDHL LSMRNNWPIT LNEHVICTRL PAPDMEFQSG QPVLGAFLSE
     AIMDVMPQTT SPFNECVILA TICGRSLFHA QQYSVRFVYG ELAPNWTDQH QWLDNVLTNR
     LQILSQYYPS PTQICDPMLS FAHIMGQASV IHLYKGMASV VWAVDDGAWV VEYQRRALSA
     AQEIVKLAKG LTEFNFFKVC HTASLPCND