CTP5A_RAT
ID CTP5A_RAT Reviewed; 1305 AA.
AC Q0V8T6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Contactin-associated protein like 5-1;
DE AltName: Full=Cell recognition molecule Caspr5-1;
DE AltName: Full=Cell recognition molecule Caspr5a;
DE AltName: Full=Contactin-associated protein-like 5a;
DE Flags: Precursor;
GN Name=Cntnap5a; Synonyms=Caspr5-1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=16845472; DOI=10.1007/s00335-005-0157-1;
RA Traut W., Weichenhan D., Himmelbauer H., Winking H.;
RT "New members of the neurexin superfamily: multiple rodent homologues of the
RT human CASPR5 gene.";
RL Mamm. Genome 17:723-731(2006).
CC -!- FUNCTION: May play a role in the correct development and proper
CC functioning of the peripheral and central nervous system and be
CC involved in cell adhesion and intercellular communication.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the neurexin family. {ECO:0000305}.
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DR EMBL; AABR03084638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03084763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03084792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03084826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03084916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03085048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03085225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03085340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03085455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03085761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03086666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BN000868; CAJ55730.1; -; mRNA.
DR RefSeq; NP_001041330.1; NM_001047865.1.
DR AlphaFoldDB; Q0V8T6; -.
DR SMR; Q0V8T6; -.
DR STRING; 10116.ENSRNOP00000044412; -.
DR GlyGen; Q0V8T6; 5 sites.
DR iPTMnet; Q0V8T6; -.
DR PhosphoSitePlus; Q0V8T6; -.
DR PaxDb; Q0V8T6; -.
DR Ensembl; ENSRNOT00000111316; ENSRNOP00000095092; ENSRNOG00000070614.
DR GeneID; 297832; -.
DR KEGG; rno:297832; -.
DR UCSC; RGD:1559812; rat.
DR CTD; 636808; -.
DR RGD; 1559812; Cntnap5a.
DR eggNOG; KOG3516; Eukaryota.
DR GeneTree; ENSGT00940000164023; -.
DR InParanoid; Q0V8T6; -.
DR OrthoDB; 338397at2759; -.
DR PhylomeDB; Q0V8T6; -.
DR PRO; PR:Q0V8T6; -.
DR Proteomes; UP000002494; Chromosome 13.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR InterPro; IPR028874; Caspr5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR15036:SF70; PTHR15036:SF70; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF49899; SSF49899; 4.
DR SUPFAM; SSF56496; SSF56496; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 2: Evidence at transcript level;
KW Cell adhesion; Disulfide bond; EGF-like domain; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..1305
FT /note="Contactin-associated protein like 5-1"
FT /id="PRO_0000317381"
FT TRANSMEM 1238..1258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 25..174
FT /note="F5/8 type C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT DOMAIN 180..360
FT /note="Laminin G-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 367..544
FT /note="Laminin G-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 546..583
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 584..790
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT DOMAIN 791..956
FT /note="Laminin G-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 957..995
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1014..1198
FT /note="Laminin G-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT CARBOHYD 282
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 496
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 571
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 622
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1057
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 329..360
FT /evidence="ECO:0000250"
FT DISULFID 512..544
FT /evidence="ECO:0000250"
FT DISULFID 550..561
FT /evidence="ECO:0000250"
FT DISULFID 555..570
FT /evidence="ECO:0000250"
FT DISULFID 572..582
FT /evidence="ECO:0000250"
FT DISULFID 929..956
FT /evidence="ECO:0000250"
FT DISULFID 960..973
FT /evidence="ECO:0000250"
FT DISULFID 967..982
FT /evidence="ECO:0000250"
FT DISULFID 984..994
FT /evidence="ECO:0000250"
FT DISULFID 1163..1198
FT /evidence="ECO:0000250"
SQ SEQUENCE 1305 AA; 145530 MW; C39B694D81824F34 CRC64;
MDSLQRLNGL LTLVLSALWH LGLTASNYNC DDPLASFFSP MTFSSSLDLT GSYSSAQLNW
KMGTGGWSPV DSNAQQWLQI DLGNRVEITA VATQGRYGSS DWVTSYRLMF SDTGHNWQHY
TQEDSIWTFV GNMNADSVVH HRLLHSMRAR FVRFVPLEWN PNGKIGMRVE AYGCSYRSDV
ADFDGRSTLL YRFNQKTMST LKDVISLKFK SMQGDGVLFH GEGQRGDHVT LELQKGRLAL
YLNLDDSKAR LSSTVPLVIM GSLLDDQHWH SVLLERVGKQ ANFTVDMNTQ HFQTKGETDA
LDIDYELSFG GIPVPSKPGT FVKKNFHGCM ENLYYNGVNI IDLAKRRKHQ IYSGNVTFSC
SEPQIVPITF VNSRSSYLML PGTPQIDGLS VSFQFRTWNE DGLLLSTELS EGSGTLLLIL
EGGTLRLLIK KVAGHGTEIK TGSGLNDGLW HSVSINARRN RVTLTLDNDA ASPAPETSRK
QIYSGKSYYF GGCPDNLTDS QCLNPIKAFQ GCMRLIFIDN QPKDLISVQQ GSLGNFSDLH
IDLCSIKDRC LPNYCEHGGH CAQTWTTFYC NCSDTGYTGA TCHDSIYEQS CEVYRHKGHT
AGFFYVDSDG SGPLGPLQVY CNITEDKIWM TVQHNNTELT RVQGSSPEKP YSMTLNYGGS
MEQLEALIDG SEYCEQELKY HCRRSRLLNT LDGTPFTWWI GRSNERHPYW EGSVPGVQQC
GCGLEESCLD NAYFCNCDAD MDEWSNNTGL FSLKDHLPVT HVIITDTNRS NSEAAWRIGP
LRCNGDRHFW NAVSFSTEAS YLHFPTFHAE FSADISFFFK TTALSGVFLE NLGIKDFLRL
EMSSPSEVTF TIDVGNGPVE LLVQSPYPLN DNQWHYIRAE RNVKETSLQV DNLPLSLREA
SEEAYFRLHL TSQLFVGGTS SRQKGFLGCM RSLHLNGQNT DLIERAKLMS GVTPGCPGHC
SSYSSNCHNG GKCVEKQSGY SCDCTNSPNE GPFCQKEISA LFDPGTSVTY MFQEPYLVIK
NTSLLSSPIY TDTARSKETI MLNFLTAQAP TILLYLNFSS QKFLAILLSS NGSLQIRFRL
SKGESHVYTM STENLANGRV HQVKISKDGP EISIQMDQQL FSYNFSTKVE FWTLKSLVLG
KVTETLGLDP EVAKVNILGF LGCLSSVQYN HIAPLKAALR HAGVAPVTVH GTLTESGCDS
TLDSDVNAVT TVHSSLEPIG KRDEQEPLTN TVQSDSAVIG GIIAVVTFVT FCVIGIMICF
LYQHKQSHRT NQTKEKEYPE TLSNSFRNVI DLQNTASECK REYFI
