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CTP5B_RAT
ID   CTP5B_RAT               Reviewed;        1292 AA.
AC   Q0V8T5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Contactin-associated protein like 5-2;
DE   AltName: Full=Cell recognition molecule Caspr5-2;
DE   AltName: Full=Cell recognition molecule Caspr5b;
DE   AltName: Full=Contactin-associated protein-like 5b;
DE   Flags: Precursor;
GN   Name=Cntnap5b; Synonyms=Caspr5-2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=16845472; DOI=10.1007/s00335-005-0157-1;
RA   Traut W., Weichenhan D., Himmelbauer H., Winking H.;
RT   "New members of the neurexin superfamily: multiple rodent homologues of the
RT   human CASPR5 gene.";
RL   Mamm. Genome 17:723-731(2006).
CC   -!- FUNCTION: May play a role in the correct development and proper
CC       functioning of the peripheral and central nervous system and be
CC       involved in cell adhesion and intercellular communication.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the neurexin family. {ECO:0000305}.
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DR   EMBL; AABR03084824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03084984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03085000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03085128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03085301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03085395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03085665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03085695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03085869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03085874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03086267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03086376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03087382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03086635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03088686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BN000869; CAJ55731.1; -; mRNA.
DR   RefSeq; NP_001316828.1; NM_001329899.1.
DR   AlphaFoldDB; Q0V8T5; -.
DR   SMR; Q0V8T5; -.
DR   STRING; 10116.ENSRNOP00000044394; -.
DR   GlyGen; Q0V8T5; 4 sites.
DR   PhosphoSitePlus; Q0V8T5; -.
DR   PaxDb; Q0V8T5; -.
DR   GeneID; 304725; -.
DR   KEGG; rno:304725; -.
DR   RGD; 1565194; Cntnap5b.
DR   VEuPathDB; HostDB:ENSRNOG00000029556; -.
DR   eggNOG; KOG3516; Eukaryota.
DR   HOGENOM; CLU_003504_1_0_1; -.
DR   InParanoid; Q0V8T5; -.
DR   OMA; DMYVQVD; -.
DR   OrthoDB; 338397at2759; -.
DR   PhylomeDB; Q0V8T5; -.
DR   PRO; PR:Q0V8T5; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000029556; Expressed in cerebellum and 2 other tissues.
DR   Genevisible; Q0V8T5; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   CDD; cd00057; FA58C; 1.
DR   CDD; cd00110; LamG; 4.
DR   InterPro; IPR028874; Caspr5.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   PANTHER; PTHR15036:SF70; PTHR15036:SF70; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF02210; Laminin_G_2; 4.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00231; FA58C; 1.
DR   SMART; SM00282; LamG; 4.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49899; SSF49899; 4.
DR   SUPFAM; SSF56496; SSF56496; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS01286; FA58C_2; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Disulfide bond; EGF-like domain; Glycoprotein; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..1292
FT                   /note="Contactin-associated protein like 5-2"
FT                   /id="PRO_0000317382"
FT   TOPO_DOM        25..1223
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1224..1244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1245..1292
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          25..174
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00081"
FT   DOMAIN          180..360
FT                   /note="Laminin G-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   DOMAIN          367..544
FT                   /note="Laminin G-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   DOMAIN          546..583
FT                   /note="EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          584..777
FT                   /note="Fibrinogen C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT   DOMAIN          778..943
FT                   /note="Laminin G-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   DOMAIN          944..982
FT                   /note="EGF-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          987..1185
FT                   /note="Laminin G-like 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        496
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        571
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        622
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        329..360
FT                   /evidence="ECO:0000250"
FT   DISULFID        512..544
FT                   /evidence="ECO:0000250"
FT   DISULFID        550..561
FT                   /evidence="ECO:0000250"
FT   DISULFID        555..570
FT                   /evidence="ECO:0000250"
FT   DISULFID        572..582
FT                   /evidence="ECO:0000250"
FT   DISULFID        916..943
FT                   /evidence="ECO:0000250"
FT   DISULFID        947..960
FT                   /evidence="ECO:0000250"
FT   DISULFID        954..969
FT                   /evidence="ECO:0000250"
FT   DISULFID        971..981
FT                   /evidence="ECO:0000250"
FT   DISULFID        1150..1185
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1292 AA;  144159 MW;  6B7C9670DFF60618 CRC64;
     MDSILRLTSI LTWLLSGLWH VGLTATNYNC DDPLASFLSP VAYSSSSDIT GSTSSAQLNW
     RMGTGGWSPA DSSAHQWLQL DLGNRVEITA VATQGRYGSA DWVTSYHLMF SDTGHNWQQY
     KQENSIWTFA GNLNADSVVH HKLLHSVRAR FIRFVPMEWN RNGNIGMRVE VYGCSYKSDV
     ADFDGQSSLL YRFSQKTMST LKDVISLKFK SMQGDGVLFH GEGQRGDHIT LELQNGRLVL
     YLNLDDKKAW LSSITPSAIL GSLLDDQHWH SVFLERVGKQ VNFTVDRNTQ HFWTKGETEV
     LDIDYELSFG GIPVPSKPGT FVKKNFHGCI ENLYYNGVNI IDLAKRRKHQ IYSGNVTFSC
     SEPQIVPITF VNSRSSYLFL PGTPQIDGLS VSFQFRTWNE DGLLLSTELS EGSGTLLLIL
     ESGTLRLLIK KVTGHGTESL TGRSLNDGRW HSVSINVRRN RVTLTVDNDA VSLAPETSGL
     QIYSGNSYYF GGCPDNLTVS QCLNPIKAFQ GCMRLIFIDN QPKDLISVQQ GSLGNFSDLH
     IDLCSIKDRC LPNYCEHGGH CTQTWTSFYC NCSDTGYTGA TCHNSIYEQS CEIYRHRGNK
     AGFFYVDSDG SGPLGPLQVY CNVTEDKIWM TVQHTITELT QVQGSNSEKP YAMTLNYGGS
     MEQLEALIDG SEHCEQEVTY RCRRAHLFNT QDEAPFTWWI GRSNERHPYW GGYVPGVQQC
     GCGLEESCQE IASNTGFLSS KDHLPVTQII ITNSNRTNSE AAWRIGPLRC YGDRHFWNAV
     SFSTEASYLH FSAFHVEFSA DISFFFKTTA LSGIFLENLG IKGFLRLEMS SPSEVIFAID
     VGNSPIELLV QSPYPLNDNQ WHYIQAERNI KETLLQVDNL PKNKREVSDQ SNFLLQLSSQ
     LFIGGTSSRQ KGFLGCIRSL HLNGQKIDLE ERAKITPGVR PGCPGHCSSY GRNCHNGGKC
     VEKHNGYSCD CTNSPFEGPF CQKEMSALFY SGTSVTYMFQ EPYPVAKNTS LSSSAIYKDT
     APSKEIVTLS FITAQAPALL LYLKFSPQSF LAILLSRNGS LQIHYQLSKV ESHVFTVGSE
     NLANRRVHEV NMNRNGQELS IQVDQQLFSY NFSPEVEFQT VRSLILGKVT ETLVLNPEVT
     QANTLGFVGC LSSVQYNHIA PLKAALRHAS IAPVTVQGTL TESSCGSMVE SYANGVTTVY
     SSSDPFGNTD EHEPLTNAIQ SDSAFIGGVI AIVTFIAFGV IGIMTHFLYQ HKQSHHTNPM
     KEKEYPENLD SSFRNDIDLQ NTVSDCKREY FI
 
 
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