ID   CTPAL_STAEQ             Reviewed;         491 AA.
AC   Q5HPB7;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Probable CtpA-like serine protease;
DE            EC=3.4.21.-;
GN   OrderedLocusNames=SERP0996;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S41A family. {ECO:0000305}.
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DR   EMBL; CP000029; AAW54358.1; -; Genomic_DNA.
DR   RefSeq; WP_002486217.1; NC_002976.3.
DR   AlphaFoldDB; Q5HPB7; -.
DR   SMR; Q5HPB7; -.
DR   STRING; 176279.SERP0996; -.
DR   EnsemblBacteria; AAW54358; AAW54358; SERP0996.
DR   KEGG; ser:SERP0996; -.
DR   eggNOG; COG0793; Bacteria.
DR   HOGENOM; CLU_017295_3_0_9; -.
DR   OMA; DPHSSYY; -.
DR   OrthoDB; 1646508at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd07560; Peptidase_S41_CPP; 1.
DR   Gene3D; 1.10.101.10; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004447; Peptidase_S41A.
DR   InterPro; IPR002477; Peptidoglycan-bd-like.
DR   InterPro; IPR036365; PGBD-like_sf.
DR   InterPro; IPR036366; PGBDSf.
DR   InterPro; IPR005151; Tail-specific_protease.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF03572; Peptidase_S41; 1.
DR   Pfam; PF01471; PG_binding_1; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00245; TSPc; 1.
DR   SUPFAM; SSF47090; SSF47090; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   TIGRFAMs; TIGR00225; prc; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Reference proteome;
KW   Serine protease; Transmembrane; Transmembrane helix.
FT   CHAIN           1..491
FT                   /note="Probable CtpA-like serine protease"
FT                   /id="PRO_0000233195"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          119..201
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        324
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        335
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        349
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   491 AA;  55107 MW;  F72254A789CED87B CRC64;
     MNDHQKNHAT SQDDNTKSTP SKNSKHIKIK LWHFILVILG IILLTSIITV VSTILISHQK
     SGLNKEQRAN LKKIEYVYQT LNKDYYKKQS SDKLTQSAID GMVKELKDPY SEYMTAEETK
     QFNEGVSGDF VGIGAEMQKK NEQISVTSPM KDSPAEKAGI QPKDIVTQVN HHSVVGKPLD
     QVVKMVRGKK GTYVTLTIKR GSQEKDIKIK RDTIHVKSVE YEKKGNVGVL TINKFQSNTS
     GELKSAIIKA HKQGIRHIIL DLRNNPGGLL DEAVKMANIF IDKGNTVVQL EKGKDKEELK
     TSNQALKQAK DMKVSILVNE GSASASEVFT GAMKDYHKAK VYGSKTFGKG IVQTIREFSD
     GSLIKYTEMK WLTPDGHYIH GKGIRPDVSI STPKYQSLNV IPDNKTYHQG EKDKNVKTMK
     IGLKALGYPI DNETNIFDEQ LESAIKTFQQ DNNLKVNGNF DKKTNDKFTE KLVEKANKKD
     TVLNDLLNKL K