ID   CTPAL_STAES             Reviewed;         491 AA.
AC   Q8CSK8;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Probable CtpA-like serine protease;
DE            EC=3.4.21.-;
GN   OrderedLocusNames=SE_1113;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S41A family. {ECO:0000305}.
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DR   EMBL; AE015929; AAO04710.1; -; Genomic_DNA.
DR   RefSeq; NP_764668.1; NC_004461.1.
DR   RefSeq; WP_001831212.1; NZ_WBME01000002.1.
DR   AlphaFoldDB; Q8CSK8; -.
DR   SMR; Q8CSK8; -.
DR   STRING; 176280.SE_1113; -.
DR   EnsemblBacteria; AAO04710; AAO04710; SE_1113.
DR   GeneID; 50018764; -.
DR   KEGG; sep:SE_1113; -.
DR   PATRIC; fig|176280.10.peg.1086; -.
DR   eggNOG; COG0793; Bacteria.
DR   HOGENOM; CLU_017295_3_0_9; -.
DR   OMA; DPHSSYY; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd07560; Peptidase_S41_CPP; 1.
DR   Gene3D; 1.10.101.10; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004447; Peptidase_S41A.
DR   InterPro; IPR002477; Peptidoglycan-bd-like.
DR   InterPro; IPR036365; PGBD-like_sf.
DR   InterPro; IPR036366; PGBDSf.
DR   InterPro; IPR005151; Tail-specific_protease.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF03572; Peptidase_S41; 1.
DR   Pfam; PF01471; PG_binding_1; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00245; TSPc; 1.
DR   SUPFAM; SSF47090; SSF47090; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   TIGRFAMs; TIGR00225; prc; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Serine protease;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..491
FT                   /note="Probable CtpA-like serine protease"
FT                   /id="PRO_0000233196"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          119..201
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        324
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        335
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        349
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   491 AA;  55095 MW;  F8D17E8E89CEC252 CRC64;
     MNDHQKNHAT SQDDNTKSTP SKNSKHIKIK LWHFILVILG IILLTSIITV VSTILISHQK
     SGLNKEQRAN LKKIEYVYQT LNKDYYKKQS SDKLTQSAID GMVKELKDPY SEYMTAEETK
     QFNEGVSGDF VGIGAEMQKK NEQISVTSPM KDSPAEKAGI QPKDIVTQVN HHSVVGKPLD
     QVVKMVRGKK GTYVTLTIKR GSQEKDIKIK RDTIHVKSVE YEKKGNVGVL TINKFQSNTS
     GELKSAIIKA HKQGIRHIIL DLRNNPGGLL DEAVKMANIF IDKGNTVVQL EKGKDKEELK
     TSNQALKQAK DMKVSILVNE GSASASEVFT GAMKDYHKAK VYGSKTFGKG IVQTTREFSD
     GSLIKYTEMK WLTPDGHYIH GKGIRPDVSI STPKYQSLNV IPDNKTYHQG EKDKNVKTMK
     IGLKALGYPI DNETNIFDEQ LESAIKTFQQ DNNLKVNGNF DKKTNDKFTE KLVEKANKKD
     TVLNDLLNKL K