ID   CTPAL_STAHJ             Reviewed;         496 AA.
AC   Q4L6D0;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Probable CtpA-like serine protease;
DE            EC=3.4.21.-;
GN   OrderedLocusNames=SH1486;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S41A family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE04795.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AP006716; BAE04795.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q4L6D0; -.
DR   SMR; Q4L6D0; -.
DR   STRING; 279808.SH1486; -.
DR   EnsemblBacteria; BAE04795; BAE04795; SH1486.
DR   KEGG; sha:SH1486; -.
DR   eggNOG; COG0793; Bacteria.
DR   HOGENOM; CLU_017295_3_0_9; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd07560; Peptidase_S41_CPP; 1.
DR   Gene3D; 1.10.101.10; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004447; Peptidase_S41A.
DR   InterPro; IPR002477; Peptidoglycan-bd-like.
DR   InterPro; IPR036365; PGBD-like_sf.
DR   InterPro; IPR036366; PGBDSf.
DR   InterPro; IPR005151; Tail-specific_protease.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF03572; Peptidase_S41; 1.
DR   Pfam; PF01471; PG_binding_1; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00245; TSPc; 1.
DR   SUPFAM; SSF47090; SSF47090; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   TIGRFAMs; TIGR00225; prc; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Serine protease;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..496
FT                   /note="Probable CtpA-like serine protease"
FT                   /id="PRO_0000233197"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          124..206
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        329
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        340
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        354
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   496 AA;  55330 MW;  3E8B8668E47D91E7 CRC64;
     MRKCFFMSHN PEEKQSNLDS NHKNESSSNK RIKFKTWQFI LLLLGVVIIT AGITVAATIG
     ISHKISGLTK DERQEIKKIE YAYKTLNNDY YKKQNAGKLS EAAIDGMVKE LKDPYSEYMT
     KDETKSFNED VSGDFVGIGA EMQKKDKQIM ITSPMKDSPA EKAGIQPKDV VTKVDGKSVV
     GKPLDQVVKL VRGKEGTTVK LTIKRGSQEK EIKIKRGKIH VKSVEYKKKD NIGVFTINKF
     QDNTAGELKS AIIKAHKDGV RSIVLDLRNN PGGLLDEAVK MANIFIDKDQ TVVKLEKGDD
     TESIKTSNDA SNEAKDMKVS ILVNEGSASA SEVFTGAMRD HKKAKVYGSK TFGKGIVQTT
     REFKDGSLLK YTQMKWLTPD GHNIHGKGIQ PDTKIASPQY QSISVIPTDK SYSVGDNTKY
     VKSIKIGLDA LGYNVNNDSK QFDTQLESAI KKFQSEHELS VNGKFDKKTN EKFTQLLVEK
     ANKEDKVLDE LINKLK