ID   CTPAL_STAS1             Reviewed;         491 AA.
AC   Q49XN1;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Probable CtpA-like serine protease;
DE            EC=3.4.21.-;
GN   OrderedLocusNames=SSP1319;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S41A family. {ECO:0000305}.
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DR   EMBL; AP008934; BAE18464.1; -; Genomic_DNA.
DR   RefSeq; WP_011303100.1; NZ_MTGA01000038.1.
DR   AlphaFoldDB; Q49XN1; -.
DR   SMR; Q49XN1; -.
DR   STRING; 342451.SSP1319; -.
DR   EnsemblBacteria; BAE18464; BAE18464; SSP1319.
DR   KEGG; ssp:SSP1319; -.
DR   PATRIC; fig|342451.11.peg.1321; -.
DR   eggNOG; COG0793; Bacteria.
DR   HOGENOM; CLU_017295_3_0_9; -.
DR   OMA; TFNQVDW; -.
DR   OrthoDB; 1646508at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd07560; Peptidase_S41_CPP; 1.
DR   Gene3D; 1.10.101.10; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004447; Peptidase_S41A.
DR   InterPro; IPR002477; Peptidoglycan-bd-like.
DR   InterPro; IPR036365; PGBD-like_sf.
DR   InterPro; IPR036366; PGBDSf.
DR   InterPro; IPR005151; Tail-specific_protease.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF03572; Peptidase_S41; 1.
DR   Pfam; PF01471; PG_binding_1; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00245; TSPc; 1.
DR   SUPFAM; SSF47090; SSF47090; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   TIGRFAMs; TIGR00225; prc; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Reference proteome;
KW   Serine protease; Transmembrane; Transmembrane helix.
FT   CHAIN           1..491
FT                   /note="Probable CtpA-like serine protease"
FT                   /id="PRO_0000233198"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          119..201
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        324
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        335
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        349
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   491 AA;  54652 MW;  AD54069AB34524F6 CRC64;
     MSESKDTTEV NQEVNEKASS QSTKKQINFK RSHFIIILIV TILVTAMIAV FATIGISHWT
     SGLNSDQRDE MKKVEQVYQT LDDEYYKDTS SEELGTAAID GMVKKLDDPY SDYMTKKETK
     SFNEDVSGDF VGIGAEMQKK GNQIQITSPM KQSPAEKAGI QPKDVVTKVN GKSIKGQPLE
     AIVKKVRGKQ GTKVTLTIER GGQAHDITIK RDKIHVKSVE YQKHGDVGVF TINKFQNSTS
     GELKSAIIKA HKDGIRKIVL DLRNNPGGLL DEAVKMANIF IDKNETVVQL EKGKHKEAIK
     ASNDASKEAK DMDVSILVNK GSASASEVFT GAMKDYNKAK VYGSKTFGKG IVQTTREFED
     GSLLKFTNMK WLTPKSHYIH GKGITPDKKI EEPAYQSLNV IPSNKTYQLG DDDKNVKTMK
     VGLNVLGYHI NNHSTEFDSE LEDALKSFQK KNNLDVNGTF NKSTNEKFTQ QLVEKANKED
     TVLNELLKKL N