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CTPG_MYCBO
ID   CTPG_MYCBO              Reviewed;         771 AA.
AC   P63690; A0A1R3XZZ2; Q10866; X2BJ77;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Probable cation-transporting ATPase G;
DE            EC=7.2.2.-;
GN   Name=ctpG; OrderedLocusNames=BQ2027_MB2015C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IB subfamily. {ECO:0000305}.
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DR   EMBL; LT708304; SIU00622.1; -; Genomic_DNA.
DR   RefSeq; NP_855665.1; NC_002945.3.
DR   RefSeq; WP_003899120.1; NC_002945.4.
DR   AlphaFoldDB; P63690; -.
DR   SMR; P63690; -.
DR   EnsemblBacteria; SIU00622; SIU00622; BQ2027_MB2015C.
DR   PATRIC; fig|233413.5.peg.2214; -.
DR   OMA; HLHLMET; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0019829; F:ATPase-coupled cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1110.10; -; 1.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR027256; P-typ_ATPase_IB.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   SUPFAM; SSF81653; SSF81653; 1.
DR   SUPFAM; SSF81665; SSF81665; 1.
DR   TIGRFAMs; TIGR01525; ATPase-IB_hvy; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Magnesium; Membrane; Metal-binding;
KW   Nucleotide-binding; Phosphoprotein; Translocase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..771
FT                   /note="Probable cation-transporting ATPase G"
FT                   /id="PRO_0000046344"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        411..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        657..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        716..736
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          19..86
FT                   /note="HMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   REGION          122..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        462
FT                   /note="4-aspartylphosphate intermediate"
FT                   /evidence="ECO:0000250"
FT   BINDING         651
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
FT   BINDING         655
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   771 AA;  79309 MW;  31281C919CC116CA CRC64;
     MTTVVDAEVQ LTVVSDAAGR MRVQATGFQF DAGRAVAIED TVGKVAGVQA VHAYPRTASI
     VIWYSRAICD TAAILSAIID AETVPAAAVP AYASRSASNR KAGVVQKIID WSTRTLSGVR
     RDVAAQPSGE TSDACCDGED NEDREPEQLW QVAKLRRAAF SGVLLTASLV AAWAYPLWPV
     VLGLKALALA VGASTFVPSS LKRLAEGRVG VGTLMTIAAL GAVALGELGE AATLAFLFSI
     SEGLEEYATA RTRRGLRALL SLVPDQATVL REGTETIVAS TELHVGDQMI VKPGERLATD
     GIIRAGRTAL DVSAITGESV PVEVGPGDEV FAGSINGLGV LQVGVTATAA NNSLARIVHI
     VEAEQVRKGA SQRLADCIAR PLVPSIMIAA ALIAGTGSVL GNPLVWIERA LVVLVAAAPC
     ALAIAVPVTV VASIGAASRL GVLIKGGAAL ETLGTIRAVA LDKTGTLTAN RPVVIDVATT
     NGATREEVLA VAAALEARSE HPLAVAVLAA TQATTAASDV QAVPGAGLIG RLDGRVVRLG
     RPGWLDAAEL ADHVACMQQA GATAVLVERD QQLLGAIAVR DELRPEAAEV VAGLRTGGYQ
     VTMLTGDNHA TAAALAAQAG IEQVHAELRP EDKAHLVAQL RARQPTAMVG DGVNDAPALA
     AADLGIAMGA MGTDVAIETA DVALMGQDLR HLPQALDHAR RSRQIMVQNV GLSLSIITVL
     MPLALFGILG LAAVVLVHEF TEVIVIANGV RAGRIKPLAG PPKTPDRTIP G
 
 
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