CTPI_MYCLE
ID CTPI_MYCLE Reviewed; 1609 AA.
AC O53114;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Probable cation-transporting ATPase I;
DE EC=7.2.2.-;
GN Name=ctpI; OrderedLocusNames=ML2671; ORFNames=MLCB1913.02;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL022118; CAA17934.1; -; Genomic_DNA.
DR EMBL; AL583926; CAC32203.1; -; Genomic_DNA.
DR PIR; E87243; E87243.
DR RefSeq; NP_302704.1; NC_002677.1.
DR AlphaFoldDB; O53114; -.
DR SMR; O53114; -.
DR STRING; 272631.ML2671; -.
DR EnsemblBacteria; CAC32203; CAC32203; CAC32203.
DR KEGG; mle:ML2671; -.
DR PATRIC; fig|272631.5.peg.5145; -.
DR Leproma; ML2671; -.
DR eggNOG; COG0474; Bacteria.
DR HOGENOM; CLU_002360_0_1_11; -.
DR OMA; PKAARYG; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1110.10; -; 1.
DR Gene3D; 3.40.50.1000; -; 2.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR SUPFAM; SSF81653; SSF81653; 1.
DR SUPFAM; SSF81665; SSF81665; 1.
DR TIGRFAMs; TIGR01494; ATPase_P-type; 2.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Magnesium; Membrane; Metal-binding;
KW Nucleotide-binding; Phosphoprotein; Reference proteome; Translocase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1609
FT /note="Probable cation-transporting ATPase I"
FT /id="PRO_0000046346"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 641..661
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 673..693
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 778..798
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 921..941
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 969..989
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 997..1017
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1396..1416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1426..1446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1542..1562
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1573..1593
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1447..1476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1053
FT /note="4-aspartylphosphate intermediate"
FT /evidence="ECO:0000250"
FT BINDING 1335
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 1339
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1609 AA; 166873 MW; 58FA2079905E3995 CRC64;
MKIPHVTDPV SNMVGGMAQV VRASTHAATG AVNTMQMLAS PVAEFAWPVV QSVAKSTGRA
LGTGHSPNFA NRVDPPVRWH NGQRVHLDLD PLLPFPRWHE YAAVVEEPVR RIPGVAKGHV
EGSLGRLVIE LDKNADSDVV LGKVRDVVIA LAADLALTGA RSAPKVAPFA DPGNPLAILM
PLTAAVMDLV ALSAAVTGWV TRLPAVPQTI RAAAALVNHQ PRMVSLLESR LGRVGTDIAL
SITTAAASGL TQAVGTPLLD LACRGLQLSE AAAHQRVWRD REPQLASPKR PQAPVVPVIS
SAGEKSHAAG HNWTAAASNE ASHLVVGGSI DAAIDTAKGS MKGPVESYVD SAANGSLIAA
ASALLAGGGT EDAAGAILAG VPRAAHMGQQ AFAATLGRGL ANAGQLVLDP GALRRLDQVK
VVVIDGAALR GDHRAVLLAR GNTPGWDDDR VYEVTDALLH GERAPEPDPD ESPATGARLR
WVPLQGPSAT PVQGREHADL VVNGECVGGV DVGWEVDPYA IPLLQTAHRT GARVVLRHVA
GTEDLSASVG ATHPPGTPLL KLVRELRTDR GPVLLITAVH RDFASTDTLA ALAIADVGVA
LDDPHAATPW TADIITGTDL AAAVRILSAL PVARSASESS VHLAQGGTTL AGLLLITASA
GSKSASPITL RRWFSPVNAA AATALVTGVV SASKVLRLPD PTPQPLTAWH ALDPEIVYSR
LAGVTQPLAV EPGTPDWRRR LDDLSYTRAL SPLRKPVTKL ARLASATRQE FADPLTPILA
VGAAASAIVG SNIDALLVAG VMTVNAITGG VQRLRAEAAA AELFAEQDQL VRRVVVPAVA
TTRRRLEAAQ HATRTVTVSA KSLRAGDVID LAAPEVVPAD ARVLVAEDLE VDESLLTGES
LPVDKRVDPV AINDADRASM LFEGSAIVAG HARAIVVATG VGTAAHRAIS AVADVEVSAG
VQARLRELTS KVLPLTLAGG AAVTGLALLR RASLRQAVAD GVAIAVAAVP EGLPLVATLS
QLAAAQRLTA KGALVRSPRT IEALGRVDTI CFDKTGTLTE NRLRVVCAVP NTRMPHDPLP
DITDPHSAAV LRDAARASTQ PHDGQGHTHA TDEAILTAAS SLNSHTDSTW SLIAEVPFES
SRGYAAAIGI TGNGKAPMLM LKGAPEKILP RCRFADPEAD VAHAESLVRH LAEQGLRVLA
VAQCSWGHDT TDDNDTDADA VDAAAHDLEL VGYIGLADTA RPSSRPLIEA LVTAGRNVVL
ITGDHPITAR AIAQQLGLRS DARVVNGTEL IGLDEDACAE LAADVQVFAR VSPEQKVQIV
AALQRCGQVT AMVGDGANDA AAIRMADVGI GVSGRGSSAA RGAADIVLTD DDLGVLLDAL
VEGRSMWAGV RDAVTILVGG NVGEVVFTII GTVFGAGRAP VGTRQLLLVN LLTDMFPALS
IAVTSQYEEP GEDEYQTDEE ADEARRTHQH EVLTGPTPSL DAPLMRQIVN RGVVTAAGAT
TAWAIGRWTP GTERRTATMG LTALVTTQLA QTLLTRRHSP LVVATALGSA GVLIGIIQTP
VISQFFGCTP LGPIAWSGVI TATAGATAVS VLAPQWLNKA FGIAQLNQE
