CTR1_OCTVU
ID CTR1_OCTVU Reviewed; 397 AA.
AC Q7YW31;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Cephalotocin receptor 1;
DE AltName: Full=OC/CE-R 1;
DE AltName: Full=OT/VP superfamily peptide receptor 1;
GN Name=CTR1 {ECO:0000312|EMBL:BAD67169.1};
OS Octopus vulgaris (Common octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=6645;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAC81147.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Brain {ECO:0000269|PubMed:14596680};
RX PubMed=14596680; DOI=10.1677/joe.0.1790281;
RA Kanda A., Takuwa-Kuroda K., Iwakoshi-Ukena E., Furukawa Y., Matsushima O.,
RA Minakata H.;
RT "Cloning of Octopus cephalotocin receptor, a member of the
RT oxytocin/vasopressin superfamily.";
RL J. Endocrinol. 179:281-291(2003).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAD67169.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC TISSUE=Vein {ECO:0000312|EMBL:BAD67169.1};
RX PubMed=15504101; DOI=10.1042/bj20041230;
RA Kanda A., Satake H., Kawada T., Minakata H.;
RT "Novel evolutionary lineages of the invertebrate oxytocin/vasopressin
RT superfamily peptides and their receptors in the common octopus (Octopus
RT vulgaris).";
RL Biochem. J. 387:85-91(2005).
CC -!- FUNCTION: Acts as a receptor for cephalotocin.
CC {ECO:0000269|PubMed:14596680}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Present in brain, buccal ganglion, gastric
CC ganglion, olfactory lube, peduncle lobe, optical lobe, pancreas, the
CC oviduct and the ovary. {ECO:0000269|PubMed:14596680,
CC ECO:0000269|PubMed:15504101}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; AB090945; BAC81147.1; -; mRNA.
DR EMBL; AB158493; BAD67169.1; -; Genomic_DNA.
DR AlphaFoldDB; Q7YW31; -.
DR SMR; Q7YW31; -.
DR Proteomes; UP000515154; Genome assembly.
DR GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016500; F:protein-hormone receptor activity; IDA:UniProtKB.
DR GO; GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..397
FT /note="Cephalotocin receptor 1"
FT /id="PRO_0000235829"
FT TOPO_DOM 1..48
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..91
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..331
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..397
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 118..194
FT /evidence="ECO:0000250|UniProtKB:P34981,
FT ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 397 AA; 45751 MW; BCD2BCE75E9F5B4B CRC64;
MRYITTHPNE ISTQIWNNFS STEIWSNFSA AKNETQPIRR NQDLANAEVI TLAVVIIITV
IGNSIVLITL FQRRKKLTRM HLFILHLSVT DLFVAFFNNL PQMIWDITFL FLGTDLLCRL
VTYLQSVAMY ASSYVLVATA IDRYFAICHP LSSHKWTTAR VHVMVFIAWM LSFLFSTPQL
FIWSMQFSNI GLTCQATFDP EWTLKFYITW LTVAIWILPT IALTLFYGMM CFAVWKRGRS
TLGSSRTRNR SFLTNRVSTR IGQSHLARGF SEEDMEGQSV NYNRGISRAK VRSVALTLSV
VACCFICWSP FFVCQMWAAW DENAPYSGAI YTILLLLSSL NSCTNPWIYM IFSVFQHRAK
TSRFVNDEET TSVTVLSSRN DIRLMSMKKK LEQTARN
