CTR2_DANRE
ID CTR2_DANRE Reviewed; 640 AA.
AC Q5PR34;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Cationic amino acid transporter 2;
DE Short=CAT-2;
DE Short=CAT2;
DE AltName: Full=Low affinity cationic amino acid transporter 2;
DE AltName: Full=Solute carrier family 7 member 2;
GN Name=slc7a2; ORFNames=zgc:103686;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Low-affinity, high capacity permease involved in the
CC transport of the cationic amino acids (arginine, lysine and ornithine).
CC {ECO:0000250|UniProtKB:P18581}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18581};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P18581}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000305}.
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DR EMBL; BC086843; AAH86843.1; -; mRNA.
DR RefSeq; NP_001008584.1; NM_001008584.1.
DR AlphaFoldDB; Q5PR34; -.
DR SMR; Q5PR34; -.
DR STRING; 7955.ENSDARP00000104882; -.
DR PaxDb; Q5PR34; -.
DR GeneID; 494041; -.
DR KEGG; dre:494041; -.
DR CTD; 6542; -.
DR ZFIN; ZDB-GENE-041212-5; slc7a2.
DR eggNOG; KOG1286; Eukaryota.
DR InParanoid; Q5PR34; -.
DR OrthoDB; 439017at2759; -.
DR PhylomeDB; Q5PR34; -.
DR Reactome; R-DRE-352230; Amino acid transport across the plasma membrane.
DR PRO; PR:Q5PR34; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015189; F:L-lysine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0000064; F:L-ornithine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR GO; GO:0097638; P:L-arginine import across plasma membrane; IBA:GO_Central.
DR GO; GO:1903352; P:L-ornithine transmembrane transport; IBA:GO_Central.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004755; Cat_AA_permease.
DR InterPro; IPR029485; CAT_C.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR TIGRFAMs; TIGR00906; 2A0303; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..640
FT /note="Cationic amino acid transporter 2"
FT /id="PRO_0000375229"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..64
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..161
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..190
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..338
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 360..384
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..408
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 430..486
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 508..519
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 520..540
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 541..551
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 573..579
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 580..600
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 601..640
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 217
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 225
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 238
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 640 AA; 69466 MW; 32C65DE320BF307D CRC64;
MLEHCLTFGR SLVRRKNVDQ GCLEESKLCR CLSTVDLIAL GVGSTLGAGV YVLAGEVAKG
SSGPSIVVSF LIAALASVMA GLCYAEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS
YVIGTSSVAR AWSGTFDEII GGHIEKFCKM YFKMSLPGLA EYPDFFAVCL ILLLSGLLSF
GVKESAWVNK IFTAVNVLVL MFVIISGFVK GDSLNWNISE ESLVNITVVK RNISSAANVT
SDYGAGGFFP YGFGGTLAGA ATCFYAFVGF DCIATTGEEV KNPQRAIPIG IVVSLLVCFL
AYFGVSAALT LMMPYYLLDE KSPLPLAFEY VGWGPAKYVV AAGSLCALST SLLGSMFPLP
RILFAMARDG VLFRFLSKLS KRQSPVAATM AAGTTAAIMA FLFDLKALVD MMSIGTLLAY
SLVAACVLIL RYQPDASFER SRISEGKEEV GESELTESES HLNMLKDGGV TLRSLLHPPL
LPTENTSSVV NVSVIITVLV VCVVSTLNTY YGQAIIAMEL WALGVLAASL FIFIICVFLI
CRQPQTRKKV SFMVPLLPFL PILSIFVNVY LMVQLSGDTW IRFSIWMAIG FLIYFGYGMW
HSDERKRHLQ NCAVATEKKT LTGNEGFVEN KTHTEKTSPC
