CTR2_OCTVU
ID CTR2_OCTVU Reviewed; 426 AA.
AC Q5WA50; Q5W9T6;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Cephalotocin receptor 2;
GN Name=CTR2 {ECO:0000312|EMBL:BAD67167.1};
OS Octopus vulgaris (Common octopus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Octopodiformes; Octopoda; Incirrata; Octopodidae; Octopus.
OX NCBI_TaxID=6645;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAD67167.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Branchia {ECO:0000269|PubMed:15504101};
RX PubMed=15504101; DOI=10.1042/bj20041230;
RA Kanda A., Satake H., Kawada T., Minakata H.;
RT "Novel evolutionary lineages of the invertebrate oxytocin/vasopressin
RT superfamily peptides and their receptors in the common octopus (Octopus
RT vulgaris).";
RL Biochem. J. 387:85-91(2005).
CC -!- FUNCTION: Acts as a receptor for cephalotocin.
CC {ECO:0000269|PubMed:15504101}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Present in various peripheral tissues with highest
CC expression in branchia and vas deferens. Very low expression detected
CC in nervous system. {ECO:0000269|PubMed:15504101}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; AB112347; BAD67167.1; -; mRNA.
DR EMBL; AB158494; BAD67170.1; -; Genomic_DNA.
DR EMBL; AB158495; BAD67171.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5WA50; -.
DR SMR; Q5WA50; -.
DR Proteomes; UP000515154; Genome assembly.
DR GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016500; F:protein-hormone receptor activity; IDA:UniProtKB.
DR GO; GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:UniProtKB.
DR GO; GO:0046887; P:positive regulation of hormone secretion; TAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..426
FT /note="Cephalotocin receptor 2"
FT /id="PRO_0000233902"
FT TOPO_DOM 1..51
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..319
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 341..426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 373..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 119..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 426 AA; 49398 MW; 88146A5EBA7BD8A4 CRC64;
MYQAMEVEST SPSGFFLDFY TQSTIPTTDF LNNTNSSHPI RDEKLVKIEI AVLGTCFTLA
IINNLCVLLV LLWRRKKVRR MQMFILHLSI ADLIVAFFNI LPQLIWDITF RFMAGDAMCR
FIKYAQMFSL YLSTYILIMT AVDRYRAICH PLSNQTWTPC MVYCKIFIAY AIATIFSIPQ
AILFQMQEVN EGSGIYDCWV HFEPAWVLTA YALYIFFALY LIPILILFFT YGSICYTIWA
KYRHAIKTKK DANTRYPQRR KKKGVILRTH SVHGFSKAKL NSVKLTFAVI VTYIICWSPF
FVSQIWWLFD ETVVGNAGVV VILLMACLNS CTNPWIYLIF NRNYISNVLP CKCLRRHRVE
VAATTETERL SLGSVRRDSR KTSDPKRISE SRRISDARRI SGKTQKNNSS SPRKTSDQFI
YSDKTT
