CTR2_XENLA
ID CTR2_XENLA Reviewed; 622 AA.
AC Q6DCE8;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Cationic amino acid transporter 2;
DE Short=CAT-2;
DE Short=CAT2;
DE AltName: Full=Low affinity cationic amino acid transporter 2;
DE AltName: Full=Solute carrier family 7 member 2;
GN Name=slc7a2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Low-affinity, high capacity permease involved in the
CC transport of the cationic amino acids (arginine, lysine and ornithine).
CC {ECO:0000250|UniProtKB:P18581}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18581};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P18581}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC078099; AAH78099.1; -; mRNA.
DR RefSeq; NP_001087158.1; NM_001093689.1.
DR AlphaFoldDB; Q6DCE8; -.
DR SMR; Q6DCE8; -.
DR DNASU; 447047; -.
DR GeneID; 447047; -.
DR KEGG; xla:447047; -.
DR CTD; 447047; -.
DR Xenbase; XB-GENE-5763998; slc7a2.2.L.
DR OMA; YGLFMCL; -.
DR OrthoDB; 439017at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 447047; Expressed in camera-type eye and 6 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004755; Cat_AA_permease.
DR InterPro; IPR029485; CAT_C.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR TIGRFAMs; TIGR00906; 2A0303; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..622
FT /note="Cationic amino acid transporter 2"
FT /id="PRO_0000375230"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..66
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..163
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..192
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..249
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..340
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 362..386
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 408..409
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 431..473
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 495..501
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 523..532
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 533..553
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 554..559
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 581..622
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 234
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 239
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 622 AA; 66932 MW; C5333925F2334B19 CRC64;
MKPYEGLYSF YKILTRTKHV TLEGTGSSDL CRCLSTLDLV ALGVGSTLGA GVYVLAGEVA
KVDSGPSIII SFLIAALASV LAGLCYAEFG ARVPLTGSAY LYSYVTVGEL WAFITGWNLI
LSYVIGTSSV ARAWSATFDE LVGKKIGNFL GNTMHMDLPG LAEYPDIFAV CLIILLAGLL
SFGVKESTAV NKVFTAINIL VLLFVIASGC VTGNLKYWKM SKEDLWATKQ SVSNHSIGNE
TGLDFGAGGF MPFGFSGTLA GAATCFYAFV GFDCIATTGE EVKNPQKSIP LGIVLSLSIC
FFAYFGVSAS LTLMMPYHLL DSQSPLPAAF EYVGWNVAKY IVAVGSLCAL TTSLLGSMFP
MPRILFAMAR DGLLFQPLSR VSSRQSPVIA TIVSGVVAAL MAFLFNLKAL VDMMSIGTLL
AYTLVSTCVL LLRYQPQTDF GKSPDGNLQE QNISSISHLP ETPSVHSSAL VTRCVIAITL
LVCVASVVST VGSQCLLSGR AWCLSLLVLS LLGIIIALVI IWRQPQNQSK ATFMVPFVPV
LPVVSILVNI YLMVQLSTDT WLRYAVWMAV GFVIYFGYGI RHSIERLHLK ETCTQKMAIS
STETLCKAQC LELQLGEAKP MD
