CTR2_YEAST
ID CTR2_YEAST Reviewed; 189 AA.
AC P38865; D3DLC3;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Copper transport protein CTR2;
DE Short=Copper transporter 2;
GN Name=CTR2; OrderedLocusNames=YHR175W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP POSSIBLE FUNCTION.
RX PubMed=7499355; DOI=10.1074/jbc.270.47.28479;
RA Kampfenkel K.K.K., Kushnir S., Babiychuk E., Inze D., Vanmontagu M.;
RT "Molecular characterization of a putative Arabidopsis thaliana copper
RT transporter and its yeast homologue.";
RL J. Biol. Chem. 270:28479-28486(1995).
RN [4]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=15494390; DOI=10.1074/jbc.m411669200;
RA Rees E.M., Lee J., Thiele D.J.;
RT "Mobilization of intracellular copper stores by the ctr2 vacuolar copper
RT transporter.";
RL J. Biol. Chem. 279:54221-54229(2004).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Provides bioavailable copper via mobilization of vacuolar
CC copper stores and export to the cytoplasm.
CC {ECO:0000269|PubMed:15494390}.
CC -!- SUBUNIT: Homomultimer. {ECO:0000269|PubMed:15494390}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:15494390};
CC Multi-pass membrane protein {ECO:0000269|PubMed:15494390}.
CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC SLC31A subfamily. {ECO:0000305}.
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DR EMBL; U00027; AAB68020.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06867.1; -; Genomic_DNA.
DR PIR; S48914; S48914.
DR RefSeq; NP_012045.3; NM_001179306.3.
DR AlphaFoldDB; P38865; -.
DR SMR; P38865; -.
DR BioGRID; 36608; 38.
DR DIP; DIP-4763N; -.
DR IntAct; P38865; 5.
DR MINT; P38865; -.
DR STRING; 4932.YHR175W; -.
DR TCDB; 1.A.56.1.3; the copper transporter (ctr) family.
DR PaxDb; P38865; -.
DR PRIDE; P38865; -.
DR EnsemblFungi; YHR175W_mRNA; YHR175W; YHR175W.
DR GeneID; 856580; -.
DR KEGG; sce:YHR175W; -.
DR SGD; S000001218; CTR2.
DR VEuPathDB; FungiDB:YHR175W; -.
DR eggNOG; KOG3386; Eukaryota.
DR HOGENOM; CLU_079690_4_0_1; -.
DR InParanoid; P38865; -.
DR OMA; NTCVIFH; -.
DR BioCyc; YEAST:G3O-31208-MON; -.
DR Reactome; R-SCE-425410; Metal ion SLC transporters.
DR PRO; PR:P38865; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38865; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IMP:SGD.
DR GO; GO:0006878; P:cellular copper ion homeostasis; IMP:SGD.
DR GO; GO:0015677; P:copper ion import; IGI:SGD.
DR GO; GO:0015680; P:protein maturation by copper ion transfer; IMP:SGD.
DR InterPro; IPR007274; Cop_transporter.
DR PANTHER; PTHR12483; PTHR12483; 1.
DR Pfam; PF04145; Ctr; 2.
PE 1: Evidence at protein level;
KW Copper; Copper transport; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..189
FT /note="Copper transport protein CTR2"
FT /id="PRO_0000195046"
FT TOPO_DOM 1..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..142
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..189
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 189 AA; 21651 MW; 15112FB67C9A47CD CRC64;
MDDKKTWSTV TLRTFNQLVT SSLIGYSKKM DSMNHKMEGN AGHDHSDMHM GDGDDTCSMN
MLFSWSYKNT CVVFEWWHIK TLPGLILSCL AIFGLAYLYE YLKYCVHKRQ LSQRVLLPNR
SLTKINQADK VSNSILYGLQ VGFSFMLMLV FMTYNGWLML AVVCGAIWGN YSWCTSYSPE
IDDSSLACH
