CTR3_RAT
ID CTR3_RAT Reviewed; 619 AA.
AC O08812;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Cationic amino acid transporter 3;
DE Short=CAT-3;
DE Short=CAT3;
DE AltName: Full=Cationic amino acid transporter y+;
DE AltName: Full=Solute carrier family 7 member 3;
GN Name=Slc7a3; Synonyms=Atrc3, Cat3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Wistar; TISSUE=Brain;
RX PubMed=9079705; DOI=10.1074/jbc.272.13.8717;
RA Hosokawa H., Sawamura T., Kobayashi S., Ninomiya H., Miwa S., Masaki T.;
RT "Cloning and characterization of a brain-specific cationic amino acid
RT transporter.";
RL J. Biol. Chem. 272:8717-8722(1997).
CC -!- FUNCTION: Mediates the uptake of the cationic amino acids arginine,
CC lysine and ornithine in a sodium-independent manner.
CC {ECO:0000269|PubMed:9079705}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain.
CC {ECO:0000269|PubMed:9079705}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000305}.
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DR EMBL; AB000113; BAA20133.1; -; mRNA.
DR RefSeq; NP_058913.1; NM_017217.1.
DR AlphaFoldDB; O08812; -.
DR SMR; O08812; -.
DR STRING; 10116.ENSRNOP00000068222; -.
DR GlyGen; O08812; 1 site.
DR PaxDb; O08812; -.
DR GeneID; 29485; -.
DR KEGG; rno:29485; -.
DR UCSC; RGD:68342; rat.
DR CTD; 84889; -.
DR RGD; 68342; Slc7a3.
DR eggNOG; KOG1286; Eukaryota.
DR InParanoid; O08812; -.
DR PhylomeDB; O08812; -.
DR Reactome; R-RNO-352230; Amino acid transport across the plasma membrane.
DR PRO; PR:O08812; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015174; F:basic amino acid transmembrane transporter activity; IDA:RGD.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IDA:RGD.
DR GO; GO:0015189; F:L-lysine transmembrane transporter activity; IDA:RGD.
DR GO; GO:0000064; F:L-ornithine transmembrane transporter activity; IDA:RGD.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR GO; GO:0097638; P:L-arginine import across plasma membrane; ISO:RGD.
DR GO; GO:1903826; P:L-arginine transmembrane transport; IDA:RGD.
DR GO; GO:0097639; P:L-lysine import across plasma membrane; ISO:RGD.
DR GO; GO:0097640; P:L-ornithine import across plasma membrane; ISO:RGD.
DR GO; GO:1903352; P:L-ornithine transmembrane transport; IBA:GO_Central.
DR GO; GO:0015819; P:lysine transport; IDA:RGD.
DR GO; GO:0015822; P:ornithine transport; IDA:RGD.
DR GO; GO:0032006; P:regulation of TOR signaling; IMP:RGD.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR015606; CAT3.
DR InterPro; IPR004755; Cat_AA_permease.
DR InterPro; IPR029485; CAT_C.
DR PANTHER; PTHR43243:SF20; PTHR43243:SF20; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR TIGRFAMs; TIGR00906; 2A0303; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Cell membrane; Glycoprotein; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..619
FT /note="Cationic amino acid transporter 3"
FT /id="PRO_0000054268"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..107
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..162
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..191
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..244
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..285
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..335
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..356
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..382
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 404..406
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..475
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..496
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 497..507
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 529..540
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 541..561
FT /note="Helical; Name=13"
FT /evidence="ECO:0000255"
FT TOPO_DOM 562..569
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 570..590
FT /note="Helical; Name=14"
FT /evidence="ECO:0000255"
FT TOPO_DOM 591..619
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 606
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8WY07"
FT MOD_RES 618
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WY07"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 619 AA; 67525 MW; 07448958386AB9EE CRC64;
MLWQALRRFG QKLVRRRLLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV YVLAGEVAKE
KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY SYVTVGELWA FTTGWNLILS
YVIGTASVAR AWSSAFDNLI GNHISQTLKG TILLNMPHVL AEYPDFFALA LVLLLTGLLV
LGANESGLVT KVFTGMNLLV LGFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM
GSGGFMPFGL EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSICFLAYF
GVSSALTLMM PYYKLQPESP LPEAFTYVGW EPARYLVAIG SLCALSTSLL GSMFPMPRVI
YAMAEDGLLF RVLARVHNGT HTPIVATVVS GVIAAFMAFL FELTDLVDLM SIGTLLAYSL
VSICVLILRY QPDQEMKNGE EEVELQEERT LEAEKLTVQA LFCQVDSIPT LLSGRIVYVC
SSLLAVLLTV LCLVLTWWTT PLHSGDPVWV TVVVLILGLI LGISGVIWRQ PQNRTPLHFK
VPVVPLLPLV SIFVNVYLMM QMTADTWARF GVWMLIGFAI YFGYGIQHSV EEVKNHQTLP
KTRPQTIDLD LTTSCVHSI
